GenomeNet

Database: UniProt
Entry: Q8IVF2
LinkDB: Q8IVF2
Original site: Q8IVF2 
ID   AHNK2_HUMAN             Reviewed;        5795 AA.
AC   Q8IVF2; Q5BKX7; Q7Z343; Q7Z358; Q7Z394; Q7Z3G0; Q86WQ6; Q8IYY1; Q8N3G4;
AC   Q96EX9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   07-OCT-2020, entry version 131.
DE   RecName: Full=Protein AHNAK2;
GN   Name=AHNAK2; Synonyms=C14orf78, KIAA2019;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA   Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA   Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA   Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA   Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA   Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA   Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA   Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA   Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA   Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA   Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA   Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA   Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA   Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 1-77 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE
RP   MRNA] OF 1-647 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF
RP   5281-5795 (ISOFORMS 1/2/3), AND VARIANT ALA-5397.
RC   TISSUE=Eye, Kidney, Skin, Testis, and Uterine adenocarcinoma;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-631 (ISOFORM 3).
RC   TISSUE=Astrocyte;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2994-5795 (ISOFORMS 1/3).
RC   TISSUE=Brain;
RA   Nagase T., Kikuno R., Ohara O.;
RT   "The nucleotide sequence of a long cDNA clone isolated from human.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4587-5795 (ISOFORMS 1/3), AND
RP   VARIANTS ALA-4664; ASP-5184 AND ALA-5397.
RC   TISSUE=Colon endothelium, Melanoma, and Uterus;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT   networks.";
RL   Cell 127:635-648(2006).
RN   [7]
RP   INTERACTION WITH DYSF.
RX   PubMed=17185750; DOI=10.1096/fj.06-6628com;
RA   Huang Y., Laval S.H., van Remoortere A., Baudier J., Benaud C.,
RA   Anderson L.V., Straub V., Deelder A., Frants R.R., den Dunnen J.T.,
RA   Bushby K., van der Maarel S.M.;
RT   "AHNAK, a novel component of the dysferlin protein complex, redistributes
RT   to the cytoplasm with dysferlin during skeletal muscle regeneration.";
RL   FASEB J. 21:732-742(2007).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280 AND SER-294, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [9]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1510; LYS-1840 AND LYS-2500, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19608861; DOI=10.1126/science.1175371;
RA   Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA   Olsen J.V., Mann M.;
RT   "Lysine acetylation targets protein complexes and co-regulates major
RT   cellular functions.";
RL   Science 325:834-840(2009).
RN   [10]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; SER-593; SER-842;
RP   SER-1007; SER-1112; SER-1337; SER-1502; SER-1667; SER-1832; SER-2162;
RP   SER-2492; SER-2822; SER-2987; SER-3152; SER-3408; SER-3812; SER-3977;
RP   SER-4142; SER-4307; SER-4472; SER-4477; SER-4894 AND SER-4897, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [11]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [12]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA   Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT   "System-wide temporal characterization of the proteome and phosphoproteome
RT   of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:RS3-RS3(2011).
RN   [13]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; SER-294; SER-593;
RP   SER-1418; SER-2243; SER-2408; SER-2738; SER-3068; SER-3233; SER-3408;
RP   SER-4388; SER-4477 AND SER-5707, AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [14]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-116, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25772364; DOI=10.1016/j.celrep.2015.02.033;
RA   Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V.,
RA   Vertegaal A.C.;
RT   "SUMO-2 orchestrates chromatin modifiers in response to DNA damage.";
RL   Cell Rep. 10:1778-1791(2015).
RN   [15]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-116, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25755297; DOI=10.1074/mcp.o114.044792;
RA   Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V.,
RA   Vertegaal A.C.;
RT   "System-wide analysis of SUMOylation dynamics in response to replication
RT   stress reveals novel small ubiquitin-like modified target proteins and
RT   acceptor lysines relevant for genome stability.";
RL   Mol. Cell. Proteomics 14:1419-1434(2015).
RN   [16]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-116, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=28112733; DOI=10.1038/nsmb.3366;
RA   Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA   Nielsen M.L.;
RT   "Site-specific mapping of the human SUMO proteome reveals co-modification
RT   with phosphorylation.";
RL   Nat. Struct. Mol. Biol. 24:325-336(2017).
RN   [17] {ECO:0000244|PDB:4CN0}
RP   X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 108-203, AND SUBUNIT.
RX   PubMed=24675079; DOI=10.1074/jbc.m114.554816;
RA   Han H., Kursula P.;
RT   "Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through
RT   domain swapping.";
RL   J. Biol. Chem. 289:14121-14131(2014).
CC   -!- SUBUNIT: Homodimer (via PDZ domain) (PubMed:24675079). Interacts with
CC       DYSF; the interaction is direct and Ca(2+)-independent
CC       (PubMed:17185750). {ECO:0000269|PubMed:17185750,
CC       ECO:0000269|PubMed:24675079}.
CC   -!- INTERACTION:
CC       Q8IVF2-2; Q9H0R8: GABARAPL1; NbExp=3; IntAct=EBI-10217765, EBI-746969;
CC       Q8IVF2-2; P60520: GABARAPL2; NbExp=3; IntAct=EBI-10217765, EBI-720116;
CC       Q8IVF2-3; P07306: ASGR1; NbExp=3; IntAct=EBI-12078468, EBI-1172335;
CC       Q8IVF2-3; P23141-3: CES1; NbExp=3; IntAct=EBI-12078468, EBI-12360993;
CC       Q8IVF2-3; O43169: CYB5B; NbExp=3; IntAct=EBI-12078468, EBI-1058710;
CC       Q8IVF2-3; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-12078468, EBI-2680384;
CC       Q8IVF2-3; Q92520: FAM3C; NbExp=3; IntAct=EBI-12078468, EBI-2876774;
CC       Q8IVF2-3; Q9H0R8: GABARAPL1; NbExp=8; IntAct=EBI-12078468, EBI-746969;
CC       Q8IVF2-3; P24593: IGFBP5; NbExp=3; IntAct=EBI-12078468, EBI-720480;
CC       Q8IVF2-3; Q59EV6: PPGB; NbExp=3; IntAct=EBI-12078468, EBI-14210385;
CC       Q8IVF2-3; Q96NZ9: PRAP1; NbExp=3; IntAct=EBI-12078468, EBI-2116102;
CC       Q8IVF2-3; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-12078468, EBI-12195249;
CC       Q8IVF2-3; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-12078468, EBI-10243654;
CC       Q8IVF2-3; Q9Y5Z9: UBIAD1; NbExp=3; IntAct=EBI-12078468, EBI-2819725;
CC       Q8IVF2-3; Q15836: VAMP3; NbExp=3; IntAct=EBI-12078468, EBI-722343;
CC       Q8IVF2-3; O95159: ZFPL1; NbExp=3; IntAct=EBI-12078468, EBI-718439;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q8IVF2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8IVF2-2; Sequence=VSP_031550;
CC       Name=3;
CC         IsoId=Q8IVF2-3; Sequence=VSP_031551;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH49216.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAH90889.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAC23115.1; Type=Frameshift; Evidence={ECO:0000305};
DR   EMBL; AL512802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AI915159; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC011859; AAH11859.2; -; mRNA.
DR   EMBL; BC033372; AAH33372.1; -; mRNA.
DR   EMBL; BC049216; AAH49216.1; ALT_INIT; mRNA.
DR   EMBL; BC090889; AAH90889.1; ALT_INIT; mRNA.
DR   EMBL; AK094143; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AB095939; BAC23115.1; ALT_FRAME; mRNA.
DR   EMBL; AL834367; CAD39030.1; -; mRNA.
DR   EMBL; BX537923; CAD97904.1; -; mRNA.
DR   EMBL; BX538040; CAD97981.1; -; mRNA.
DR   EMBL; BX538106; CAD98019.1; -; mRNA.
DR   EMBL; BX538133; CAD98034.1; -; mRNA.
DR   CCDS; CCDS45177.1; -. [Q8IVF2-1]
DR   RefSeq; NP_612429.2; NM_138420.2. [Q8IVF2-1]
DR   RefSeq; XP_005267356.1; XM_005267299.1.
DR   PDB; 4CN0; X-ray; 1.75 A; A/B=108-203.
DR   PDBsum; 4CN0; -.
DR   SMR; Q8IVF2; -.
DR   BioGRID; 125226; 49.
DR   IntAct; Q8IVF2; 36.
DR   STRING; 9606.ENSP00000353114; -.
DR   iPTMnet; Q8IVF2; -.
DR   MetOSite; Q8IVF2; -.
DR   PhosphoSitePlus; Q8IVF2; -.
DR   SwissPalm; Q8IVF2; -.
DR   BioMuta; AHNAK2; -.
DR   DMDM; 172045740; -.
DR   EPD; Q8IVF2; -.
DR   jPOST; Q8IVF2; -.
DR   MassIVE; Q8IVF2; -.
DR   MaxQB; Q8IVF2; -.
DR   PaxDb; Q8IVF2; -.
DR   PeptideAtlas; Q8IVF2; -.
DR   PRIDE; Q8IVF2; -.
DR   ProteomicsDB; 70688; -. [Q8IVF2-1]
DR   ProteomicsDB; 70689; -. [Q8IVF2-2]
DR   ProteomicsDB; 70690; -. [Q8IVF2-3]
DR   Antibodypedia; 28280; 123 antibodies.
DR   DNASU; 113146; -.
DR   Ensembl; ENST00000333244; ENSP00000353114; ENSG00000185567. [Q8IVF2-1]
DR   Ensembl; ENST00000557457; ENSP00000450998; ENSG00000185567. [Q8IVF2-2]
DR   GeneID; 113146; -.
DR   KEGG; hsa:113146; -.
DR   UCSC; uc010axc.2; human. [Q8IVF2-1]
DR   CTD; 113146; -.
DR   DisGeNET; 113146; -.
DR   EuPathDB; HostDB:ENSG00000185567.6; -.
DR   GeneCards; AHNAK2; -.
DR   HGNC; HGNC:20125; AHNAK2.
DR   HPA; ENSG00000185567; Tissue enriched (skin).
DR   MIM; 608570; gene.
DR   neXtProt; NX_Q8IVF2; -.
DR   OpenTargets; ENSG00000185567; -.
DR   PharmGKB; PA162376085; -.
DR   eggNOG; ENOG502R1NR; Eukaryota.
DR   GeneTree; ENSGT00940000163336; -.
DR   HOGENOM; CLU_019457_0_0_1; -.
DR   InParanoid; Q8IVF2; -.
DR   KO; K23934; -.
DR   OMA; VDHQTPG; -.
DR   OrthoDB; 71329at2759; -.
DR   PhylomeDB; Q8IVF2; -.
DR   TreeFam; TF350595; -.
DR   PathwayCommons; Q8IVF2; -.
DR   BioGRID-ORCS; 113146; 9 hits in 878 CRISPR screens.
DR   ChiTaRS; AHNAK2; human.
DR   GenomeRNAi; 113146; -.
DR   Pharos; Q8IVF2; Tbio.
DR   PRO; PR:Q8IVF2; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; Q8IVF2; protein.
DR   Bgee; ENSG00000185567; Expressed in tendon of biceps brachii and 204 other tissues.
DR   Genevisible; Q8IVF2; HS.
DR   GO; GO:0043034; C:costamere; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0042383; C:sarcolemma; NAS:UniProtKB.
DR   GO; GO:0030315; C:T-tubule; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; ISS:UniProtKB.
DR   GO; GO:0043484; P:regulation of RNA splicing; IBA:GO_Central.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Alternative splicing; Isopeptide bond; Nucleus;
KW   Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation.
FT   CHAIN           1..5795
FT                   /note="Protein AHNAK2"
FT                   /id="PRO_0000319962"
FT   DOMAIN          112..193
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   MOD_RES         280
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:18669648,
FT                   ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:23186163"
FT   MOD_RES         294
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:18669648,
FT                   ECO:0000244|PubMed:23186163"
FT   MOD_RES         593
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231,
FT                   ECO:0000244|PubMed:23186163"
FT   MOD_RES         842
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         1007
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         1112
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         1337
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         1418
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         1502
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         1510
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000244|PubMed:19608861"
FT   MOD_RES         1667
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         1832
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         1840
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000244|PubMed:19608861"
FT   MOD_RES         2162
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         2243
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         2408
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         2492
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         2500
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000244|PubMed:19608861"
FT   MOD_RES         2738
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         2822
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         2987
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         3068
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         3152
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         3233
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         3408
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231,
FT                   ECO:0000244|PubMed:23186163"
FT   MOD_RES         3812
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         3977
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         4142
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         4307
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         4388
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         4472
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         4477
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231,
FT                   ECO:0000244|PubMed:23186163"
FT   MOD_RES         4894
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         4897
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         5707
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   CROSSLNK        116
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000244|PubMed:25755297,
FT                   ECO:0000244|PubMed:25772364, ECO:0000244|PubMed:28112733"
FT   VAR_SEQ         1..5002
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031550"
FT   VAR_SEQ         1..100
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031551"
FT   VARIANT         525
FT                   /note="T -> A (in dbSNP:rs2278607)"
FT                   /id="VAR_050635"
FT   VARIANT         1266
FT                   /note="V -> M (in dbSNP:rs748458962)"
FT                   /id="VAR_039069"
FT   VARIANT         1298
FT                   /note="M -> I (in dbSNP:rs2819440)"
FT                   /id="VAR_061548"
FT   VARIANT         1470
FT                   /note="L -> V"
FT                   /id="VAR_039070"
FT   VARIANT         1856
FT                   /note="E -> D (in dbSNP:rs2819435)"
FT                   /id="VAR_059560"
FT   VARIANT         2107
FT                   /note="M -> V (in dbSNP:rs11846918)"
FT                   /id="VAR_050636"
FT   VARIANT         2115
FT                   /note="S -> R (in dbSNP:rs2582514)"
FT                   /id="VAR_039071"
FT   VARIANT         2146
FT                   /note="L -> V (in dbSNP:rs12890949)"
FT                   /id="VAR_059561"
FT   VARIANT         2410
FT                   /note="K -> R (in dbSNP:rs11845746)"
FT                   /id="VAR_050637"
FT   VARIANT         2429
FT                   /note="D -> E (in dbSNP:rs11160826)"
FT                   /id="VAR_039072"
FT   VARIANT         2430
FT                   /note="L -> V (in dbSNP:rs2819426)"
FT                   /id="VAR_039073"
FT   VARIANT         2503
FT                   /note="E -> A (in dbSNP:rs2819429)"
FT                   /id="VAR_059562"
FT   VARIANT         2616
FT                   /note="V -> A (in dbSNP:rs4264326)"
FT                   /id="VAR_039074"
FT   VARIANT         2862
FT                   /note="R -> S (in dbSNP:rs2582514)"
FT                   /id="VAR_059563"
FT   VARIANT         3176
FT                   /note="D -> E (in dbSNP:rs11160826)"
FT                   /id="VAR_059564"
FT   VARIANT         3177
FT                   /note="L -> V (in dbSNP:rs2819426)"
FT                   /id="VAR_059565"
FT   VARIANT         3336
FT                   /note="P -> L (in dbSNP:rs10438247)"
FT                   /id="VAR_059566"
FT   VARIANT         3363
FT                   /note="V -> A (in dbSNP:rs4264326)"
FT                   /id="VAR_059567"
FT   VARIANT         3654
FT                   /note="G -> E (in dbSNP:rs28380382)"
FT                   /id="VAR_061549"
FT   VARIANT         3793
FT                   /note="D -> N (in dbSNP:rs11160825)"
FT                   /id="VAR_059568"
FT   VARIANT         3796
FT                   /note="V -> L"
FT                   /id="VAR_050638"
FT   VARIANT         3869
FT                   /note="M -> V (in dbSNP:rs10438246)"
FT                   /id="VAR_059569"
FT   VARIANT         3902
FT                   /note="K -> N (in dbSNP:rs2819423)"
FT                   /id="VAR_059570"
FT   VARIANT         3961
FT                   /note="M -> V (in dbSNP:rs10141053)"
FT                   /id="VAR_050639"
FT   VARIANT         4071
FT                   /note="I -> M (in dbSNP:rs2582511)"
FT                   /id="VAR_050640"
FT   VARIANT         4085
FT                   /note="A -> V (in dbSNP:rs2013462)"
FT                   /id="VAR_059571"
FT   VARIANT         4138
FT                   /note="F -> L (in dbSNP:rs2582505)"
FT                   /id="VAR_050641"
FT   VARIANT         4198
FT                   /note="D -> N (in dbSNP:rs534942818)"
FT                   /id="VAR_059572"
FT   VARIANT         4232
FT                   /note="K -> N (in dbSNP:rs2819423)"
FT                   /id="VAR_050642"
FT   VARIANT         4278
FT                   /note="V -> A (in dbSNP:rs2819422)"
FT                   /id="VAR_050643"
FT   VARIANT         4326
FT                   /note="L -> P (in dbSNP:rs2819421)"
FT                   /id="VAR_059573"
FT   VARIANT         4478
FT                   /note="P -> L (in dbSNP:rs2582513)"
FT                   /id="VAR_059574"
FT   VARIANT         4536
FT                   /note="M -> L (in dbSNP:rs9672139)"
FT                   /id="VAR_050644"
FT   VARIANT         4664
FT                   /note="T -> A (in dbSNP:rs4465542)"
FT                   /evidence="ECO:0000269|PubMed:17974005"
FT                   /id="VAR_050645"
FT   VARIANT         5028
FT                   /note="L -> M (in dbSNP:rs9672139)"
FT                   /id="VAR_039075"
FT   VARIANT         5072
FT                   /note="G -> R (in dbSNP:rs2819420)"
FT                   /id="VAR_050646"
FT   VARIANT         5139
FT                   /note="G -> E (in dbSNP:rs61421370)"
FT                   /id="VAR_061550"
FT   VARIANT         5184
FT                   /note="Y -> D (in dbSNP:rs2819419)"
FT                   /evidence="ECO:0000269|PubMed:17974005"
FT                   /id="VAR_050647"
FT   VARIANT         5397
FT                   /note="P -> A (in dbSNP:rs3742935)"
FT                   /evidence="ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|PubMed:17974005"
FT                   /id="VAR_050648"
FT   VARIANT         5564
FT                   /note="G -> R (in dbSNP:rs2819420)"
FT                   /id="VAR_039076"
FT   VARIANT         5732
FT                   /note="T -> M (in dbSNP:rs748358)"
FT                   /id="VAR_050649"
FT   CONFLICT        3195
FT                   /note="P -> L (in Ref. 4; BAC23115)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3198
FT                   /note="A -> V (in Ref. 4; BAC23115)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        4740
FT                   /note="E -> G (in Ref. 5; CAD98019)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        5269
FT                   /note="L -> P (in Ref. 5; CAD98019)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        5560
FT                   /note="D -> G (in Ref. 5; CAD97904)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        5577
FT                   /note="I -> V (in Ref. 5; CAD97904)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        5590
FT                   /note="T -> A (in Ref. 5; CAD97981)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        5601
FT                   /note="D -> G (in Ref. 5; CAD98034)"
FT                   /evidence="ECO:0000305"
FT   STRAND          111..116
FT                   /evidence="ECO:0000244|PDB:4CN0"
FT   STRAND          125..130
FT                   /evidence="ECO:0000244|PDB:4CN0"
FT   STRAND          136..141
FT                   /evidence="ECO:0000244|PDB:4CN0"
FT   HELIX           146..149
FT                   /evidence="ECO:0000244|PDB:4CN0"
FT   STRAND          158..165
FT                   /evidence="ECO:0000244|PDB:4CN0"
FT   HELIX           171..181
FT                   /evidence="ECO:0000244|PDB:4CN0"
FT   STRAND          184..193
FT                   /evidence="ECO:0000244|PDB:4CN0"
SQ   SEQUENCE   5795 AA;  616629 MW;  BEC73677308C1FAB CRC64;
     MCDCFHMVLP TWPGTPGSVS GRQLQPGEPG AETEDDHSVT EGPADEGIRP RPQGSSPVYE
     YTTEAADFGL QEDAPGRQGS AGRRRSWWKR DSGDSRTFFR MSRPEAVQEA TEVTLKTEVE
     AGASGYSVTG GGDQGIFVKQ VLKDSSAAKL FNLREGDQLL STTVFFENIK YEDALKILQY
     SEPYKVQFKI RRQLPAPQDE EWASSDAQHG PQGKEKEDTD VADGCRETPT KTLEGDGDQE
     RLISKPRVGR GRQSQRERLS WPKFQSIKSK RGPGPQRSHS SSEAYEPRDA HDVSPTSTDT
     EAQLTVERQE QKAGPGSQRR RKFLNLRFRT GSGQGPSSTG QPGRGFQSGV GRAGVLEELG
     PWGDSLEETG AATGSRREER AEQDREVMPA QSMPLPTELG DPRLCEGTPQ EGGLRAARLH
     GKTLEGQAQE TAVAQRKPRA QPTPGMSREG EGEGLQSLEI GIARLSLRDT TEGGTQIGPP
     EIRVRVHDLK TPKFAFSTEK EPERERRLST PQRGKRQDAS SKAGTGLKGE EVEGAGWMPG
     REPTTHAEAQ GDEGDGEEGL QRTRITEEQD KGREDTEGQI RMPKFKIPSL GWSPSKHTKT
     GREKATEDTE QGREGEATAT ADRREQRRTE EGLKDKEDSD SMTNTTKIQL IHDEKRLKKE
     QILTEKEVAT KDSKFKMPKF KMPLFGASAP GKSMEASVDV SAPKVEADVS LLSMQGDLKT
     TDLSVQTPSA DLEVQDGQVD VKLPEGPLPE GASLKGHLPK VQRPSLKMPK VDLKGPKLDL
     KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGARLEGDLS LADKEVTAKD SKFKMPKFKM
     PSFGVSAPGK SMEDSVDVSA PKVEADVSLS SMQGDLKATD LSIQPPSADL EVQAGQVDVK
     LPEGPVPEGA GPKVHLPKVE MPSFKMPKVD LKGPQIDVKG PKLDLKGPKA EVTAPDGEVS
     LPSMEVDVQA QKAKLDGAWL EGDLSLADKD VTAKDSKFKM PKFKMPSFGV SAPGKSIKAL
     VDVSAPKVEA DLSLPSMQGD LKTTDLSIQP ASTDLKVQAD QVDVKLPEGH LPEGAGLKGH
     LPKVEMPSFK MPKVALKGPQ VDVKGPKLDL KSPKAEVTAP DVEVSLPSVE VDVEAPGAKL
     DSARLEGELS LADKDVTAKD SRFKMPKFKM PSFGASAPGK SIEASVDVSA PKVEADVSLP
     SMQGDLKTTD LSIQPPSADL EVHAGQVDVK LLEGHVPEGA GFKGHLPKVQ MPSLKMPKVD
     LKGPQVEVRG PKLDLKGHKA EVTAHEVAVS LPSVEVDMQA PGAKLDGAQL DGDLSLADKD
     VTAKDSKFKM PKFKMPSFGV SAPGKSIEAS VDLSAPKVEA DMSLPSMQGD LKTTDLSIQP
     PSTDLELQAG QLDVKLPEGP VPEGAGLKGH LPKLQMPSFK VPKVDLKGPE IDIKGPKLDL
     KDPKVEVTAP DVEVSLPSVE VDVEAPGAKL DGGRLEEDMS LADKDLTTKD SKFKMPKFKM
     PSFGVSAPGK SIEASVDVSA PKVEADVSLP SMQGDLKATD LSIQPPSADL EVQAGQVDVK
     LPEGPVSEGA GLKGHLPKVQ MPSFKMPKVD LKGPQIDVKG PKLDLKGPKV EVTAPDVKMS
     LSSMEVDVQA PRAKLDGAQL EGDLSLADKA VTAKDSKFKM PKFKMPSFGV SAPGKSIEAS
     VDVSEPKVEA DVSLPSMQGD LKTTDLSIQS PSADLEVQAG QVNVKLPEGP LPEGAGFKGH
     LPKVQMPSLK MPKVALKGPQ MDVKGPKLDL KGPKAEVMAP DVEVSLPSVE VDVEAPGAKL
     DSVRLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK SIEASVDVSA PKVEAEVSLP
     SMQGDLKTTD LCIPLPSADL VVQAGQVDMK LPEGQVPEGA GLKGHLPKVD MPSFKMPKVD
     LKGPQTDVKG AKLDLKGPKA EVTAPDVEVS LPSMEVDVQA QKAKLDGARL EGDLSLADKD
     MTAKDSKFKM PKFKMPSFGV SAPGRSIEAS VDVPAPKVEA DVSLPSMQGD LKTTDLSIQP
     PSADLKVQTG QVDVKLPEGH VPEGAGLKGH LPKVEMPSLK MPKVDLKGPQ VDIKGPKLDL
     KDPKVEMRVP DVEVSLPSME VDVQAPRAKL DSAHLQGDLT LANKDLTTKD SKFKMPKFKM
     PSFGVSAPGK SIEASVDVSP PKVEADMSLP SMQGDLKTTD LSIQPLSADV KVQAGQVDVK
     LLEGPVPEEV GLKGHLPKLQ MPSFKVPKVD LKGPEIDIKG PKLDLKDPKV EVTAPDVEVS
     LPSVEVDVKA PGAKLDGARL EGDMSLADKD VTAKDSKFKM PKFKMLSFGV SALGKSIEAS
     ADVSALKVEA DVSLPSMQGD LKTTDLSVQP PSADLEVQAG QVDVKLPEGP VPEGAGLKGH
     LPKLQMPSFK MPKVDLKGPQ IDVKGPKLDL KGPKTDVMAP DVEVSQPSVE VDVEAPGAKL
     DGAWLEGDLS VADKDVTTKD SRFKIPKFKM PSFGVSAPGK SIEASVDVSA PKVEADGSLS
     SMQGDLKATD LSIQPPSADL EVQAGQVDVK LPEGPVPEGA GLKGHLPKVQ MPSFKMPEMD
     LKGPQLDVKG PKLDLKGPKA EVTAPDVEMS LSSMEVDVQA PRAKLDGARL EGDLSLADKG
     VTAKDSKFKM PKFKMPSFRV SAPGESIEAL VDVSELKVEA DMSLPSMQGD LKTTDISIQP
     PSAQLEVQAG QVDVKLPEGH VPEGAGLKGH LPKLQMPSFK MPEVDLKGPQ IDVKGPNVDL
     KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGARLEGDLS LADKGMTAKD SKFKMPKFKM
     PSFGVSAPGK SIEASVDVSE LKVEADGSFP SMQGDLKTTD IRIQPPSAQL EVQAGQVDVK
     LPEGHVPEGA GLKGHLPKVQ MPSFKMPKVD LKGPQIDVKG PKLDLKGPKA EVTAPDVEVS
     LPSVEVDVEA PRAKLDGARL EGDLSLADKD VTAKDSKFKM PKFKMPSFGV SAPGKSIEVS
     VDVSAPKVEA EVSLPSMQGD LKTTDISIEP PSAQLEVQAG QVDLKLPEGH VPEGAGLKGH
     LPKLQMPSFK MPKVDRKGPQ IDVKGPKLDL KGPKTDVTAP DVEVSQPGME VDVEAPGAKL
     DGARLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK SIEVLVDVSA PKVEADLSLP
     SMQGDLKNTD ISIEPPSAQL EVQAGQVDVK LPEGHVLEGA GLKGHLPKLQ MPSFKMPKVD
     RKGPQIDIKG PKLDLKGPKM DVTAPDVEVS QPSMEVDVEA PGAKLDGARL EGDLSLADKD
     VTAKDSKFKM PKFKMPSYRA SAPGKSIQAS VDVSAPKAEA DVSLPSMQGD LKTTDLSIQL
     PSVDLEVQAG QVDVKLPEGH VPEGAGLKGH LPKVEMPSFK MPKVDLKSPQ VDIKGPKLDL
     KVPKAEVTVP DVEVSLPSVE VDVQAPRAKL DGARLEGDLS LAEKDVTAKD SKFKMPKFKM
     PSFGVSAPGR SIEASLDVSA PKVEADVSLS SMQGDLKATD LSIQPPSADL EVQAVQVDVE
     LLEGPVPEGA GLKGHLPKVE MPSLKTPKVD LKGPQIDVKG PKLDLKGPKA EVRVPDVEVS
     LPSVEVDVQA PKAKLDAGRL EGDLSLADKD VTAKDSKFKM PKFKMPSFRV SAPGKSMEAS
     VDVSAPKVEA DVSLPSMQGD LKTTDLSIQP PSADLKVQAG QMDVKLPEGQ VPEGAGLKEH
     LPKVEMPSLK MPKVDLKGPQ VDIKGPKLDL KVSKAEVTAP DVEVSLPSVE VDVQAPRAKL
     DSAQLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK SIEASVHVSA PKVEADVSLP
     SMQGDLKTTD LSIQPHSADL TVQARQVDMK LLEGHVPEEA GLKGHLPKVQ MPSFKMPKVD
     LKGPEIDIKG PKLDLKDPKV EVTAPDVEVS LPSVEVDVEA PGAKLDGARL EGDLSLADKD
     MTAKDSKFKM PKFKMPSFGV SAPGKSMEAS VDVTAPKVEA DVSLPSMQGD LKATDLSVQP
     PSADLEVQAG QVDVKLPEGP VPEGASLKGH LPKVQMPSFK MPKVDLKGPQ IDVKGPKLDL
     KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGVQLEGDLS LADKDVTAKD SKFKMPKFKM
     PSFGVSAPGK SMEASVDVSE LKAKADVSLP SMQGDLKTTD LSIQSPSADL EVQAGQVDVK
     LPEGPLPKGA GLKGHLPKVQ MPCLKMPKVA LKGPQVDVKG PKLDLKGPKA DVMTPVVEVS
     LPSMEVDVEA PGAKLDSVRL EGDLSLADKD MTAKDSKFKM PKFKMPSFGV SAPGKSIEAS
     LDVSALKVEA DVSLPSMQGD LKTTHLSIQP PSADLEVQAG QEDVKLPEGP VHEGAGLKGH
     LPKLQMPSFK VPKVDLKGPQ IDVNVPKLDL KGPKVEVTSP NLDVSLPSME VDIQAPGAKL
     DSTRLEGDLS LADKDVTAKD SKFKMPKFKM PSFGMLSPGK SIEVSVDVSA PKMEADMSIP
     SMQGDLKTTD LRIQAPSADL EVQAGQVDLK LPEGHMPEVA GLKGHLPKVE MPSFKMPKVD
     LKGPQVDVKG PKLDLKGPKA EVMAPDVEVS LPSVETDVQA PGSMLDGARL EGDLSLAHED
     VAGKDSKFQG PKLSTSGFEW SSKKVSMSSS EIEGNVTFHE KTSTFPIVES VVHEGDLHDP
     SRDGNLGLAV GEVGMDSKFK KLHFKVPKVS FSSTKTPKDS LVPGAKSSIG LSTIPLSSSE
     CSSFELQQVS ACSEPSMQMP KVGFAGFPSS RLDLTGPHFE SSILSPCEDV TLTKYQVTVP
     RAALAPELAL EIPSGSQADI PLPKTECSTD LQPPEGVPTS QAESHSGPLN SMIPVSLGQV
     SFPKFYKPKF VFSVPQMAVP EGDLHAAVGA PVMSPLSPGE RVQCPLPSTQ LPSPGTCVSQ
     GPEELVASLQ TSVVAPGEAP SEDADHEGKG SPLKMPKIKL PSFRWSPKKE TGPKVDPECS
     VEDSKLSLVL DKDEVAPQSA IHMDLPPERD GEKGRSTKPG FAMPKLALPK MKASKSGVSL
     PQRDVDPSLS SATAGGSFQD TEKASSDGGR GGLGATASAT GSEGVNLHRP QVHIPSLGFA
     KPDLRSSKAK VEVSQPEADL PLPKHDLSTE GDSRGCGLGD VPVSQPCGEG IAPTPEDPLQ
     PSCRKPDAEV LTVESPEEEA MTKYSQESWF KMPKFRMPSL RRSFRDRGGA GKLEVAQTQA
     PAATGGEAAA KVKEFLVSGS NVEAAMSLQL PEADAEVTAS ESKSSTDILR CDLDSTGLKL
     HLSTAGMTGD ELSTSEVRIH PSKGPLPFQM PGMRLPETQV LPGEIDETPL SKPGHDLASM
     EDKTEKWSSQ PEGPLKLKAS STDMPSQISV VNVDQLWEDS VLTVKFPKLM VPRFSFPAPS
     SEDDVFIPTV REVQCPEANI DTALCKESPG LWGASILKAG AGVPGEQPVD LNLPLEAPPI
     SKVRVHIQGA QVESQEVTIH SIVTPEFVDL SVPRTFSTQI VRESEIPTSE IQTPSYGFSL
     LKVKIPEPHT QARVYTTMTQ HSRTQEGTEE APIQATPGVD SISGDLQPDT GEPFEMISSS
     VNVLGQQTLT FEVPSGHQLA DSCSDEEPAE ILEFPPDDSQ EATTPLADEG RAPKDKPESK
     KSGLLWFWLP NIGFSSSVDE TGVDSKNDVQ RSAPIQTQPE ARPEAELPKK QEKAGWFRFP
     KLGFSSSPTK KSKSTEDGAE LEEQKLQEET ITFFDARESF SPEEKEEGEL IGPVGTGLDS
     RVMVTSAART ELILPEQDRK ADDESKGSGL GPNEG
//
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