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Database: UniProt
Entry: Q8JFP1
LinkDB: Q8JFP1
Original site: Q8JFP1 
ID   IF4A2_CHICK             Reviewed;         407 AA.
AC   Q8JFP1;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-OCT-2019, entry version 115.
DE   RecName: Full=Eukaryotic initiation factor 4A-II;
DE            Short=eIF-4A-II;
DE            Short=eIF4A-II;
DE            EC=3.6.4.13;
DE   AltName: Full=ATP-dependent RNA helicase eIF4A-2;
GN   Name=EIF4A2; ORFNames=RCJMB04_14a6;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bursa of Fabricius;
RA   Tacken M.G.J., Thomas A.A.M., Peeters B.P.H., Rottier P.J.M.,
RA   Boot H.J.;
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J.,
RA   Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M.,
RA   Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: ATP-dependent RNA helicase which is a subunit of the
CC       eIF4F complex involved in cap recognition and is required for mRNA
CC       binding to ribosome. In the current model of translation
CC       initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR
CC       of mRNAs which is necessary to allow efficient binding of the
CC       small ribosomal subunit, and subsequent scanning for the initiator
CC       codon (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: eIF4F is a multi-subunit complex, the composition of
CC       which varies with external and internal environmental conditions.
CC       It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By
CC       similarity). Interacts with EIF4E (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. eIF4A
CC       subfamily. {ECO:0000305}.
DR   EMBL; AF515726; AAM53975.1; -; mRNA.
DR   EMBL; AJ720280; CAG31939.1; -; mRNA.
DR   RefSeq; NP_989880.1; NM_204549.1.
DR   RefSeq; XP_015146854.1; XM_015291368.1.
DR   SMR; Q8JFP1; -.
DR   BioGrid; 675526; 1.
DR   STRING; 9031.ENSGALP00000014119; -.
DR   PaxDb; Q8JFP1; -.
DR   PRIDE; Q8JFP1; -.
DR   GeneID; 395232; -.
DR   KEGG; gga:395232; -.
DR   CTD; 1974; -.
DR   eggNOG; KOG0327; Eukaryota.
DR   eggNOG; COG0513; LUCA.
DR   HOGENOM; HOG000268797; -.
DR   InParanoid; Q8JFP1; -.
DR   KO; K03257; -.
DR   OMA; RNPIRIL; -.
DR   OrthoDB; 726081at2759; -.
DR   PhylomeDB; Q8JFP1; -.
DR   TreeFam; TF101524; -.
DR   Reactome; R-GGA-1169408; ISG15 antiviral mechanism.
DR   Reactome; R-GGA-429947; Deadenylation of mRNA.
DR   Reactome; R-GGA-72662; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S.
DR   Reactome; R-GGA-72702; Ribosomal scanning and start codon recognition.
DR   PRO; PR:Q8JFP1; -.
DR   Proteomes; UP000000539; Unplaced.
DR   Bgee; ENSGALG00000008684; Expressed in 11 organ(s), highest expression level in spleen.
DR   ExpressionAtlas; Q8JFP1; baseline and differential.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Initiation factor; Nucleotide-binding; Protein biosynthesis;
KW   Reference proteome; RNA-binding.
FT   CHAIN         1    407       Eukaryotic initiation factor 4A-II.
FT                                /FTId=PRO_0000252336.
FT   DOMAIN       64    235       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      246    407       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND      77     84       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF        33     61       Q motif.
FT   MOTIF       183    186       DEAD box.
SQ   SEQUENCE   407 AA;  46371 MW;  0AE36D7945977EBB CRC64;
     MSGGSADYSR DHGGPEGMEP DGVIESNWNE IVDNFDDMNL KESLLRGIYA YGFEKPSAIQ
     QRAIIPCIKG YDVIAQAQSG TGKTATFAIS ILQQLEIDLK ETQALVLAPT RELAQQIQKV
     ILALGDYMGA TCHACIGGTN VRNEMQKLQA EAPHIVVGTP GRVFDMLNRR YLSPKWIKMF
     VLDEADEMLS RGFKDQIYEI FQKLSTNIQV VLLSATMPMD VLEVTKKFMR EPIRILVKKE
     ELTLEGIKQF YINVEREEWK LDTLCDLYET LTITQAVIFL NTRRKVDWLT EKMHARDFTV
     SALHGDMDQK ERDVIMREFR SGSSRVLITT DLLARGIDVQ QVSLVINYDL PTNRENYIHR
     IGRGGRFGRK GVAINFVTEE DKRILRDIET FYNTTVEEMP MNVADLI
//
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