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Database: UniProt
Entry: Q8JFU3_DANRE
LinkDB: Q8JFU3_DANRE
Original site: Q8JFU3_DANRE 
ID   Q8JFU3_DANRE            Unreviewed;       351 AA.
AC   Q8JFU3;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 2.
DT   08-MAY-2019, entry version 137.
DE   SubName: Full=Muscle, skeletal, receptor tyrosine kinase {ECO:0000313|Ensembl:ENSDARP00000139846};
DE   SubName: Full=Novel protein {ECO:0000313|EMBL:CAD43438.2};
GN   Name=musk {ECO:0000313|Ensembl:ENSDARP00000139846,
GN   ECO:0000313|ZFIN:ZDB-GENE-030131-6458};
GN   ORFNames=dZ57F23.3-001 {ECO:0000313|EMBL:CAD43438.2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:CAD43438.2};
RN   [1] {ECO:0000313|EMBL:CAD43438.2}
RP   NUCLEOTIDE SEQUENCE.
RA   Kimberley A.;
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000139846, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000139846,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000139846}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000139846};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
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DR   EMBL; CABZ01032933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01038094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR759894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU633853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU633856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL603786; CAD43438.2; -; Genomic_DNA.
DR   RefSeq; NP_956202.2; NM_199908.2.
DR   Ensembl; ENSDART00000160265; ENSDARP00000139846; ENSDARG00000098764.
DR   GeneID; 334526; -.
DR   CTD; 4593; -.
DR   ZFIN; ZDB-GENE-030131-6458; musk.
DR   eggNOG; KOG1026; Eukaryota.
DR   eggNOG; COG0515; LUCA.
DR   GeneTree; ENSGT00940000168178; -.
DR   OrthoDB; 471114at2759; -.
DR   Proteomes; UP000000437; Chromosome 10.
DR   Bgee; ENSDARG00000098764; Expressed in 17 organ(s), highest expression level in muscle tissue.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0045211; C:postsynaptic membrane; IDA:ZFIN.
DR   GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IDA:ZFIN.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
DR   GO; GO:0017147; F:Wnt-protein binding; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0007411; P:axon guidance; IMP:ZFIN.
DR   GO; GO:0008045; P:motor neuron axon guidance; IMP:ZFIN.
DR   GO; GO:0030517; P:negative regulation of axon extension; IMP:ZFIN.
DR   GO; GO:0043113; P:receptor clustering; IMP:ZFIN.
DR   GO; GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IMP:ZFIN.
DR   GO; GO:0051124; P:synaptic growth at neuromuscular junction; IMP:ZFIN.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   Pfam; PF07679; I-set; 2.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 2.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   PROSITE; PS50835; IG_LIKE; 3.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    351       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015099242.
FT   TRANSMEM    249    276       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       26    113       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      118    202       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      208    246       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   351 AA;  38939 MW;  2AD35A9BF03A083E CRC64;
     MKVPKNTPLV VFLAFFSLTE GLQRAPRITT LLETVDSSLD HNATFICEVD SYPQADIIWT
     RNNYPIRYYD SRYVIQENGQ MLIIPNVKDS DSGEYCCIAN NGVGEAKSCG ALQLKMKPQI
     KRHPTNMTLI LESKAVLPCL SLGYPKPEIS WIKEDDLIKA NNRIAILESG SLKITNIKKE
     DAGQYRCVAR NSFGIAFSRP VTIEVQAPAK ILKVPKEKRV QIGSEVTLEC NATGNPIPSI
     TWLENGNTVI LYFITYFQSF LILSHSLLFL LLALALQRKL IVLSSHLTGT ESRAQDIHVK
     CQTANLKLPA STITGGLRSV NASLGATINR IQTTIIPQSA DRATAIKFKP Y
//
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