ID Q8JJY6_SFAVA Unreviewed; 210 AA.
AC Q8JJY6; Q0E561;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Thymidine kinase {ECO:0000313|EMBL:CAC84464.1, ECO:0000313|EMBL:CAL44640.1};
GN Name=ORF040 {ECO:0000313|EMBL:CAL44640.1};
OS Spodoptera frugiperda ascovirus 1a (SfAV-1a).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Pimascovirales; Ascoviridae; Ascovirus; Ascovirus sfav1a.
OX NCBI_TaxID=113370 {ECO:0000313|EMBL:CAC84464.1};
OH NCBI_TaxID=7108; Spodoptera frugiperda (Fall armyworm).
RN [1] {ECO:0000313|EMBL:CAC84464.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=a {ECO:0000313|EMBL:CAC84464.1};
RX PubMed=14573805; DOI=10.1099/vir.0.19290-0;
RA Stasiak K., Renault S., Demattei M.V., Bigot Y., Federici B.A.;
RT "Evidence for the evolution of ascoviruses from iridoviruses.";
RL J. Gen. Virol. 84:2999-3009(2003).
RN [2] {ECO:0000313|EMBL:CAL44640.1, ECO:0000313|Proteomes:UP000008030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SvAV-1a {ECO:0000313|Proteomes:UP000008030};
RX PubMed=16987980; DOI=10.1128/JVI.01639-06;
RA Bideshi D.K., Demattei M.V., Rouleux-Bonnin F., Stasiak K., Tan Y.,
RA Bigot S., Bigot Y., Federici B.A.;
RT "Genomic sequence of Spodoptera frugiperda Ascovirus 1a, an enveloped,
RT double-stranded DNA insect virus that manipulates apoptosis for viral
RT reproduction.";
RL J. Virol. 80:11791-11805(2006).
RN [3] {ECO:0000313|EMBL:CAL44640.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19636425; DOI=10.1371/journal.pone.0006397;
RA Bigot Y., Renault S., Nicolas J., Moundras C., Demattei M.V., Samain S.,
RA Bideshi D.K., Federici B.A.;
RT "Symbiotic virus at the evolutionary intersection of three types of large
RT DNA viruses; iridoviruses, ascoviruses, and ichnoviruses.";
RL PLoS ONE 4:e6397-e6397(2009).
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DR EMBL; AJ312690; CAC84464.1; -; Genomic_DNA.
DR EMBL; AM398843; CAL44640.1; -; Genomic_DNA.
DR RefSeq; YP_762395.1; NC_008361.1.
DR GeneID; 4306161; -.
DR KEGG; vg:4306161; -.
DR OrthoDB; 12726at10239; -.
DR Proteomes; UP000008030; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019136; F:deoxynucleoside kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR002624; DCK/DGK.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR PANTHER; PTHR10513:SF35; THYMIDINE KINASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF01712; dNK; 1.
DR PIRSF; PIRSF000705; DNK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CAC84464.1};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000008030};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..188
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
FT ACT_SITE 91
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-1"
FT BINDING 13..21
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT BINDING 149..153
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
SQ SEQUENCE 210 AA; 24523 MW; 9B28484AF10C6B79 CRC64;
MTTDSVVFVS VEGNIGSGKS SVMRKAAERY DGLVYFCEEP VEEWGLLMYM YNDPARYAFP
FELQVLTSKY QKWLDSYETC LRTGARVVIM ERSPWSAYDV FTRMMRDRGS ITDKQFDVYT
DVFRSLENDI PRIDHVVYID TKPDTCHRRA QERGREAEKS LDVEYFERVE CYTKRYVDNH
SSVFVLNGNL PREDVLASFN RVLDGIVESS
//
