ID Q8JZN1_MOUSE Unreviewed; 332 AA.
AC Q8JZN1;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 161.
DE SubName: Full=Macrophage galactose N-acetyl-galactosamine specific lectin 2 {ECO:0000313|EMBL:AAI06834.1, ECO:0000313|Ensembl:ENSMUSP00000048568.6};
DE SubName: Full=Macrophage galactose-type C-type lectin 2 {ECO:0000313|EMBL:AAM52097.1};
GN Name=Mgl2 {ECO:0000313|EMBL:AAM52097.1,
GN ECO:0000313|Ensembl:ENSMUSP00000048568.6,
GN ECO:0000313|MGI:MGI:2385729};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAM52097.1};
RN [1] {ECO:0000313|EMBL:AAM52097.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=129/SvJ {ECO:0000313|EMBL:AAM52098.1}, and BAB-14
RC {ECO:0000313|EMBL:AAM52097.1};
RX PubMed=12016228; DOI=10.1074/jbc.M203774200;
RA Tsuiji M., Fujimori M., Ohashi Y., Higashi N., Onami T.M., Hedrick S.M.,
RA Irimura T.;
RT "Molecular cloning and characterization of a novel mouse macrophage C-type
RT lectin, mMGL2, which has a distinct carbohydrate specificity from mMGL1.";
RL J. Biol. Chem. 277:28892-28901(2002).
RN [2] {ECO:0000313|EMBL:AAI06834.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI06834.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000048568.6, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000048568.6,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000048568.6}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000048568.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
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DR EMBL; BC106833; AAI06834.1; -; mRNA.
DR EMBL; BC110475; AAI10476.1; -; mRNA.
DR EMBL; BC111520; AAI11521.1; -; mRNA.
DR EMBL; AY103461; AAM52097.1; -; mRNA.
DR EMBL; AY103462; AAM52098.1; -; Genomic_DNA.
DR RefSeq; NP_660119.1; NM_145137.2.
DR STRING; 10090.ENSMUSP00000048568; -.
DR PaxDb; 10090-ENSMUSP00000048568; -.
DR ProteomicsDB; 332326; -.
DR DNASU; 216864; -.
DR Ensembl; ENSMUST00000041550.12; ENSMUSP00000048568.6; ENSMUSG00000040950.14.
DR GeneID; 216864; -.
DR KEGG; mmu:216864; -.
DR UCSC; uc007jtu.1; mouse.
DR AGR; MGI:2385729; -.
DR CTD; 216864; -.
DR MGI; MGI:2385729; Mgl2.
DR VEuPathDB; HostDB:ENSMUSG00000040950; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000162036; -.
DR OMA; CSGHHED; -.
DR OrthoDB; 4787676at2759; -.
DR TreeFam; TF352155; -.
DR BioGRID-ORCS; 216864; 1 hit in 77 CRISPR screens.
DR ChiTaRS; Mgl2; mouse.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000040950; Expressed in interventricular septum and 66 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IDA:MGI.
DR GO; GO:0042806; F:fucose binding; IBA:GO_Central.
DR GO; GO:0005537; F:mannose binding; IBA:GO_Central.
DR CDD; cd03590; CLECT_DC-SIGN_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR033989; CD209-like_CTLD.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR22803:SF155; C-TYPE LECTIN DOMAIN CONTAINING 10A; 1.
DR PANTHER; PTHR22803; MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF03954; Lectin_N; 2.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lectin {ECO:0000256|ARBA:ARBA00022734, ECO:0000313|EMBL:AAM52097.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:Q8JZN1,
KW ECO:0007829|MaxQB:Q8JZN1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 46..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 196..313
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 148..182
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 8..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 332 AA; 38068 MW; 76167D0D55E253E2 CRC64;
MTMRYENFQN LEREEKNQEM RNGDKKGGME SPKFALIPSQ SFLWRILSWT HLLLFSLGLS
LLLLVVISVI GSQNSQLRRD LGTLRAILDN TTSKIKAEFQ SLDSRADNFE KGISSLKVDV
EDHRQELQAG RDLSQKVTSL ESTLEKREQA LKTDLSDLTD HVQQLETDLK ALTCQLANLK
NNGSEVACCP LHWTEHEGSC YWFSESEKSW PEADKYCRLE NSHLVVVNSL EEQNFLQNRL
ANVLSWMGLT DQNGPWRWVD GTDFDKGFKN WRPLQPDNWH GHMLGGGEDC AHFSYDGRWN
DDVCQRHYHW ICETELGKAS SAHSPQLIAS VP
//
