ID LPAR3_RAT Reviewed; 354 AA.
AC Q8K5E0; Q9ESJ6;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 146.
DE RecName: Full=Lysophosphatidic acid receptor 3;
DE Short=LPA receptor 3;
DE Short=LPA-3;
DE AltName: Full=Lysophosphatidic acid receptor Edg-7;
DE AltName: Full=snGPCR32;
GN Name=Lpar3; Synonyms=Edg7, Lpa3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RA Higashioka M., Mori K.;
RT "Molecular cloning of the rat EDG7 protein and its identification as a
RT functional cellular receptor for lysophosphatidic acid.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 8-354.
RC STRAIN=Sprague-Dawley;
RA Carroll S.L., Miller M.L., Benedict-Hamilton H.M.;
RT "Identification and characterization of novel G-protein coupled receptors
RT expressed in regenerating peripheral nerve.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for lysophosphatidic acid (LPA), a mediator of
CC diverse cellular activities. Seems to be coupled to the G(i)/G(o) and
CC G(q) families of heteromeric G proteins (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG24262.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB051164; BAB91247.1; -; mRNA.
DR EMBL; AF097733; AAG24262.1; ALT_INIT; mRNA.
DR RefSeq; NP_076459.1; NM_023969.1.
DR RefSeq; XP_006233531.1; XM_006233469.3.
DR RefSeq; XP_006233532.1; XM_006233470.3.
DR RefSeq; XP_008759744.1; XM_008761522.1.
DR RefSeq; XP_008759745.1; XM_008761523.2.
DR RefSeq; XP_017446585.1; XM_017591096.1.
DR RefSeq; XP_017446586.1; XM_017591097.1.
DR AlphaFoldDB; Q8K5E0; -.
DR SMR; Q8K5E0; -.
DR STRING; 10116.ENSRNOP00000020656; -.
DR BindingDB; Q8K5E0; -.
DR ChEMBL; CHEMBL4424; -.
DR GlyCosmos; Q8K5E0; 2 sites, No reported glycans.
DR GlyGen; Q8K5E0; 2 sites.
DR PhosphoSitePlus; Q8K5E0; -.
DR PaxDb; 10116-ENSRNOP00000020656; -.
DR GeneID; 66025; -.
DR KEGG; rno:66025; -.
DR AGR; RGD:620565; -.
DR CTD; 23566; -.
DR RGD; 620565; Lpar3.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_047979_0_0_1; -.
DR InParanoid; Q8K5E0; -.
DR OrthoDB; 5349764at2759; -.
DR PhylomeDB; Q8K5E0; -.
DR TreeFam; TF330052; -.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR Reactome; R-RNO-419408; Lysosphingolipid and LPA receptors.
DR PRO; PR:Q8K5E0; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000015260; Expressed in adult mammalian kidney and 16 other cell types or tissues.
DR GO; GO:0030424; C:axon; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0001965; F:G-protein alpha-subunit binding; IMP:RGD.
DR GO; GO:0070915; F:lysophosphatidic acid receptor activity; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IMP:RGD.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0032060; P:bleb assembly; ISO:RGD.
DR GO; GO:0048668; P:collateral sprouting; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IMP:RGD.
DR GO; GO:0010467; P:gene expression; ISO:RGD.
DR GO; GO:0051928; P:positive regulation of calcium ion transport; IMP:RGD.
DR GO; GO:0048672; P:positive regulation of collateral sprouting; ISO:RGD.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:RGD.
DR GO; GO:0019222; P:regulation of metabolic process; IBA:GO_Central.
DR CDD; cd15343; 7tmA_LPAR3_Edg7; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004065; LPA_rcpt.
DR InterPro; IPR005385; LPA_rcpt_EDG7.
DR PANTHER; PTHR22750; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR22750:SF21; LYSOPHOSPHATIDIC ACID RECEPTOR 3; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01560; EDG7RECEPTOR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01527; LPARECEPTOR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Lipoprotein;
KW Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..354
FT /note="Lysophosphatidic acid receptor 3"
FT /id="PRO_0000069435"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..186
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..354
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 309
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 15
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 74
FT /note="A -> V (in Ref. 2; AAG24262)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 354 AA; 40287 MW; 3536C8FA6EC59286 CRC64;
MNECHYDKRM DFFYNRSNTD TADEWTGTKL VIVLCVGTFF CLFIFFSNSL VIAAVITNRK
FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN RWLLRQGLLD TSLTASLANL
LVIAVERHMS IMRMRIHSNL TKKRVTLLIL LVWAIAIFMG AVPTLGWNCL CNISACSSLA
PIYSRSYLIF WTVSNLLAFF IMVVVYVRIY MYVKRKTNVL SPHTSGSISR RRAPMKLMKT
VMTVLGAFVV CWTPGLVVLL LDGLNCKQCN VQHVKRWFLL LALLNSVMNP IIYSYKDEDM
YNTMRKMICC APHDSNAERH PSRIPSTIHS RSDTGSQYLE DSISQGQVCN KSSS
//
