GenomeNet

Database: UniProt
Entry: Q8LPJ4
LinkDB: Q8LPJ4
Original site: Q8LPJ4 
ID   AB2E_ARATH              Reviewed;         605 AA.
AC   Q8LPJ4; O49679; Q56WZ4;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JAN-2019, entry version 112.
DE   RecName: Full=ABC transporter E family member 2;
DE            Short=ABC transporter ABCE.2;
DE            Short=AtABCE2;
DE   AltName: Full=RNase L inhibitor-like protein 2;
DE            Short=AtRLI2;
DE            Short=AthaRLI2;
GN   Name=ABCE2; Synonyms=RLI2; OrderedLocusNames=At4g19210;
GN   ORFNames=T18B16.180;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G.,
RA   Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N.,
RA   Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M.,
RA   Weichselgartner M., de Simone V., Obermaier B., Mache R., Mueller M.,
RA   Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T.,
RA   Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I.,
RA   Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P.,
RA   Langham S.-A., McCullagh B., Bilham L., Robben J.,
RA   van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F.,
RA   Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E.,
RA   Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P.,
RA   Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H.,
RA   De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R.,
RA   van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S.,
RA   Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R.,
RA   Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S.,
RA   Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H.,
RA   Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A.,
RA   Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R.,
RA   Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S.,
RA   Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E.,
RA   Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A.,
RA   Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T.,
RA   Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C.,
RA   Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S.,
RA   Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K.,
RA   Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L.,
RA   Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J.,
RA   Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J.,
RA   Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D.,
RA   Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D.,
RA   Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C.,
RA   Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C.,
RA   Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R.,
RA   Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S.,
RA   Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A.,
RA   Chen E., Marra M.A., Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana
RT   reference genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA   Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA   Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA   Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA   Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA   Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA   Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA   Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA   Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA   Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA   Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA   Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J.,
RA   Hayashizaki Y., Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11346655; DOI=10.1074/jbc.M103104200;
RA   Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT   "The Arabidopsis thaliana ABC protein superfamily, a complete
RT   inventory.";
RL   J. Biol. Chem. 276:30231-30244(2001).
RN   [6]
RP   GENE FAMILY.
RX   PubMed=11855639; DOI=10.1007/s004250100661;
RA   Martinoia E., Klein M., Geisler M., Bovet L., Forestier C.,
RA   Kolukisaoglu H.U., Mueller-Roeber B., Schulz B.;
RT   "Multifunctionality of plant ABC transporters -- more than just
RT   detoxifiers.";
RL   Planta 214:345-355(2002).
RN   [7]
RP   INDUCTION, AND TISSUE SPECIFICITY.
RX   PubMed=15383904; DOI=10.1007/s00239-004-2600-4;
RA   Braz A.S.K., Finnegan J., Waterhouse P., Margis R.;
RT   "A plant orthologue of RNase L inhibitor (RLI) is induced in plants
RT   showing RNA interference.";
RL   J. Mol. Evol. 59:20-30(2004).
RN   [8]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA   Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA   Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A.,
RA   Rea P.A., Samuels L., Schulz B., Spalding E.J., Yazaki K.,
RA   Theodoulou F.L.;
RT   "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL   Trends Plant Sci. 13:151-159(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, stems, leaves, flowers and
CC       siliques. {ECO:0000269|PubMed:15383904}.
CC   -!- INDUCTION: In plants undergoing RNA interference.
CC       {ECO:0000269|PubMed:15383904}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCE
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA16710.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAB78923.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; AL021687; CAA16710.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL161550; CAB78923.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002687; AEE84160.1; -; Genomic_DNA.
DR   EMBL; AY099697; AAM20548.1; -; mRNA.
DR   EMBL; BT000298; AAN15617.1; -; mRNA.
DR   EMBL; AK221885; BAD94217.1; -; mRNA.
DR   EMBL; AK226939; BAE99009.1; -; mRNA.
DR   PIR; T04442; T04442.
DR   RefSeq; NP_193656.2; NM_118041.5.
DR   UniGene; At.24747; -.
DR   UniGene; At.43389; -.
DR   ProteinModelPortal; Q8LPJ4; -.
DR   SMR; Q8LPJ4; -.
DR   BioGrid; 12954; 8.
DR   IntAct; Q8LPJ4; 8.
DR   STRING; 3702.AT4G19210.1; -.
DR   iPTMnet; Q8LPJ4; -.
DR   PaxDb; Q8LPJ4; -.
DR   PRIDE; Q8LPJ4; -.
DR   EnsemblPlants; AT4G19210.1; AT4G19210.1; AT4G19210.
DR   GeneID; 827661; -.
DR   Gramene; AT4G19210.1; AT4G19210.1; AT4G19210.
DR   KEGG; ath:AT4G19210; -.
DR   Araport; AT4G19210; -.
DR   TAIR; locus:2134761; AT4G19210.
DR   eggNOG; KOG0063; Eukaryota.
DR   eggNOG; COG1245; LUCA.
DR   HOGENOM; HOG000222803; -.
DR   InParanoid; Q8LPJ4; -.
DR   KO; K06174; -.
DR   OMA; GQYFFLE; -.
DR   OrthoDB; 359213at2759; -.
DR   PhylomeDB; Q8LPJ4; -.
DR   PRO; PR:Q8LPJ4; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; Q8LPJ4; baseline and differential.
DR   Genevisible; Q8LPJ4; AT.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IBA:GO_Central.
DR   GO; GO:0043024; F:ribosomal small subunit binding; IBA:GO_Central.
DR   GO; GO:0005215; F:transporter activity; ISS:TAIR.
DR   GO; GO:0000054; P:ribosomal subunit export from nucleus; IBA:GO_Central.
DR   GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR   GO; GO:0006415; P:translational termination; IBA:GO_Central.
DR   CDD; cd03236; ABC_RNaseL_inhibitor_domain1; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   InterPro; IPR017871; ABC_transporter_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013283; RLI1.
DR   InterPro; IPR034348; RLI_dom_1.
DR   InterPro; IPR007209; RNaseL-inhib_metal-bd_dom.
DR   PANTHER; PTHR19248; PTHR19248; 1.
DR   Pfam; PF00005; ABC_tran; 2.
DR   Pfam; PF00037; Fer4; 1.
DR   Pfam; PF04068; RLI; 1.
DR   PRINTS; PR01868; ABCEFAMILY.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   2: Evidence at transcript level;
KW   4Fe-4S; ATP-binding; Complete proteome; Iron; Iron-sulfur; Membrane;
KW   Metal-binding; Nucleotide-binding; Reference proteome; Repeat;
KW   Transport.
FT   CHAIN         1    605       ABC transporter E family member 2.
FT                                /FTId=PRO_0000379138.
FT   DOMAIN       46     75       4Fe-4S ferredoxin-type.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   DOMAIN       70    315       ABC transporter 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00434}.
FT   DOMAIN      344    568       ABC transporter 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00434}.
FT   NP_BIND     110    117       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00434}.
FT   NP_BIND     381    388       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00434}.
SQ   SEQUENCE   605 AA;  68390 MW;  8CE4ADCB3023B4C7 CRC64;
     MADRLTRIAI VSSDRCKPKK CRQECKKSCP VVKTGKLCIE VTVGSKLAFI SEELCIGCGI
     CVKKCPFEAI QIINLPRDLE KDTTHRYGAN TFKLHRLPVP RPGQVLGLVG TNGIGKSTAL
     KILAGKLKPN LGRFTSPPDW QEILTHFRGS ELQNYFTRIL EDNLKAIIKP QYVDHIPRAV
     KGNVGEVLDQ KDERDKKAEL CADLELNQVI DRDVENLSGG ELQRFAIAVV AIQNAEIYMF
     DEPSSYLDVK QRLKAAQVVR SLLRPNSYVI VVEHDLSVLD YLSDFICCLY GKPGAYGVVT
     LPFSVREGIN IFLAGFVPTE NLRFRDESLT FKVAETPQES AEEIQSYARY KYPTMTKTQG
     NFRLRVSEGE FTDSQIIVML GENGTGKTTF IRMLAGLLKP DDTEGPDREI PEFNVSYKPQ
     KISPKFQNSV RHLLHQKIRD SYMHPQFMSD VMKPLQIEQL MDQEVVNLSG GELQRVALTL
     CLGKPADIYL IDEPSAYLDS EQRIVASKVI KRFILHAKKT AFVVEHDFIM ATYLADRVIV
     YEGQPSIDCT ANCPQSLLSG MNLFLSHLNI TFRRDPTNFR PRINKLESTK DREQKSAGSY
     YYLDD
//
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