ID Q8MIS1_PIG Unreviewed; 99 AA.
AC Q8MIS1; A0A4X1UQL6;
DT 01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=KCNE3 {ECO:0000313|EMBL:AAM77424.1};
DE SubName: Full=Potassium voltage-gated channel subfamily E member 3 isoform X1 {ECO:0000313|EMBL:HDB04683.1};
DE SubName: Full=Potassium voltage-gated channel subfamily E regulatory subunit 3 {ECO:0000313|Ensembl:ENSSSCP00000024863.1};
GN Name=KCNE3 {ECO:0000313|Ensembl:ENSSSCP00000024863.1,
GN ECO:0000313|VGNC:VGNC:89337};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:AAM77424.1};
RN [1] {ECO:0000313|EMBL:AAM77424.1}
RP NUCLEOTIDE SEQUENCE.
RA Li Y., Mitchell K.E., Wymore R.S., Freeman L.C.;
RT "Granulosa cells express multiple KCNQ and KCNE channel subunits (Abstract
RT 1220).";
RL Biophys. J. 82:252a-252a(2002).
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000024863.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000024863.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:HDB04683.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [4] {ECO:0000313|Ensembl:ENSSSCP00000024863.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC {ECO:0000256|ARBA:ARBA00005688}.
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DR EMBL; AY079212; AAM77424.1; -; mRNA.
DR EMBL; DQIR01149206; HDB04683.1; -; Transcribed_RNA.
DR RefSeq; NP_999258.1; NM_214093.2.
DR RefSeq; XP_005667169.1; XM_005667112.2.
DR STRING; 9823.ENSSSCP00000048607; -.
DR PaxDb; 9823-ENSSSCP00000024863; -.
DR Ensembl; ENSSSCT00000032428.3; ENSSSCP00000024863.1; ENSSSCG00000029323.4.
DR Ensembl; ENSSSCT00000056547.2; ENSSSCP00000048607.1; ENSSSCG00000029323.4.
DR Ensembl; ENSSSCT00000092181.1; ENSSSCP00000075271.1; ENSSSCG00000029323.4.
DR Ensembl; ENSSSCT00000103236.1; ENSSSCP00000080606.1; ENSSSCG00000029323.4.
DR Ensembl; ENSSSCT00005010947.1; ENSSSCP00005006408.1; ENSSSCG00005007291.1.
DR Ensembl; ENSSSCT00005010986.1; ENSSSCP00005006431.1; ENSSSCG00005007291.1.
DR Ensembl; ENSSSCT00005011002.1; ENSSSCP00005006442.1; ENSSSCG00005007291.1.
DR GeneID; 397168; -.
DR KEGG; ssc:397168; -.
DR CTD; 10008; -.
DR VGNC; VGNC:89337; KCNE3.
DR eggNOG; ENOG502S4UF; Eukaryota.
DR GeneTree; ENSGT00940000155001; -.
DR HOGENOM; CLU_180169_0_0_1; -.
DR OMA; ANAYMYI; -.
DR OrthoDB; 5320971at2759; -.
DR TreeFam; TF335981; -.
DR Reactome; R-SSC-5576890; Phase 3 - rapid repolarisation.
DR Proteomes; UP000008227; Chromosome 9.
DR Bgee; ENSSSCG00000029323; Expressed in duodenum and 40 other cell types or tissues.
DR GO; GO:1990794; C:basolateral part of cell; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR GO; GO:0032809; C:neuronal cell body membrane; IEA:Ensembl.
DR GO; GO:0043204; C:perikaryon; IEA:Ensembl.
DR GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR GO; GO:0015459; F:potassium channel regulator activity; IBA:GO_Central.
DR GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0030644; P:intracellular chloride ion homeostasis; IEA:Ensembl.
DR GO; GO:0086011; P:membrane repolarization during action potential; IBA:GO_Central.
DR GO; GO:0098915; P:membrane repolarization during ventricular cardiac muscle cell action potential; IEA:GOC.
DR GO; GO:1905025; P:negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR GO; GO:1903765; P:negative regulation of potassium ion export across plasma membrane; IEA:Ensembl.
DR GO; GO:0097623; P:potassium ion export across plasma membrane; IBA:GO_Central.
DR GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IBA:GO_Central.
DR GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:Ensembl.
DR GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IBA:GO_Central.
DR InterPro; IPR000369; K_chnl_KCNE.
DR InterPro; IPR005426; K_chnl_volt-dep_bsu_KCNE3.
DR PANTHER; PTHR15282; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3; 1.
DR PANTHER; PTHR15282:SF6; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 3; 1.
DR Pfam; PF02060; ISK_Channel; 1.
DR PRINTS; PR01606; KCNE3CHANNEL.
DR PRINTS; PR00168; KCNECHANNEL.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 54..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 99 AA; 11336 MW; 8AAAE5FBD769175E CRC64;
METTNGTETW YESLHAVLKA LNATLHSNLL CRPGPDHLTE ERRAGLPGRD DNSYMYILFV
MFLFAATVGS LILGYTRSRK VDKRSDPYHV YIKNRVSMI
//
