GenomeNet

Database: UniProt
Entry: Q8MJ39
LinkDB: Q8MJ39
Original site: Q8MJ39 
ID   MGP_PIG                 Reviewed;         103 AA.
AC   Q8MJ39;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   31-JUL-2019, entry version 87.
DE   RecName: Full=Matrix Gla protein;
DE            Short=MGP;
DE   Flags: Precursor;
GN   Name=MGP;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Laize V., Cancela M.L.;
RT   "Identification of Sus scrofa (pig) matrix Gla protein (MGP) by
RT   comparative genomics.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Associates with the organic matrix of bone and
CC       cartilage. Thought to act as an inhibitor of bone formation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Requires vitamin K-dependent gamma-carboxylation for its
CC       function.
CC   -!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family.
CC       {ECO:0000305}.
DR   EMBL; AF525316; AAM83094.1; -; mRNA.
DR   RefSeq; NP_999281.1; NM_214116.1.
DR   SMR; Q8MJ39; -.
DR   STRING; 9823.ENSSSCP00000000637; -.
DR   PaxDb; Q8MJ39; -.
DR   PeptideAtlas; Q8MJ39; -.
DR   PRIDE; Q8MJ39; -.
DR   Ensembl; ENSSSCT00000042794; ENSSSCP00000059606; ENSSSCG00000037697.
DR   GeneID; 397206; -.
DR   KEGG; ssc:397206; -.
DR   CTD; 4256; -.
DR   eggNOG; ENOG410IZCH; Eukaryota.
DR   eggNOG; ENOG410Y2RM; LUCA.
DR   GeneTree; ENSGT00390000003753; -.
DR   HOGENOM; HOG000113581; -.
DR   InParanoid; Q8MJ39; -.
DR   KO; K19481; -.
DR   OMA; PFLNRRN; -.
DR   OrthoDB; 1512503at2759; -.
DR   TreeFam; TF330920; -.
DR   Proteomes; UP000008227; Chromosome 5.
DR   Bgee; ENSSSCG00000000606; Expressed in 6 organ(s), highest expression level in lung.
DR   ExpressionAtlas; Q8MJ39; baseline and differential.
DR   Genevisible; Q8MJ39; SS.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR   GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro.
DR   InterPro; IPR035972; GLA-like_dom_SF.
DR   InterPro; IPR000294; GLA_domain.
DR   InterPro; IPR027118; MGP.
DR   InterPro; IPR002384; Osteocalcin/MGP.
DR   PANTHER; PTHR10109; PTHR10109; 1.
DR   PRINTS; PR00002; GLABONE.
DR   SMART; SM00069; GLA; 1.
DR   SUPFAM; SSF57630; SSF57630; 1.
DR   PROSITE; PS00011; GLA_1; 1.
DR   PROSITE; PS50998; GLA_2; 1.
PE   3: Inferred from homology;
KW   Chondrogenesis; Complete proteome; Developmental protein;
KW   Differentiation; Disulfide bond; Gamma-carboxyglutamic acid;
KW   Osteogenesis; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     19       {ECO:0000250}.
FT   CHAIN        20    103       Matrix Gla protein.
FT                                /FTId=PRO_0000011112.
FT   DOMAIN       51     97       Gla. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00463}.
FT   MOD_RES      21     21       4-carboxyglutamate.
FT                                {ECO:0000250|UniProtKB:P07507,
FT                                ECO:0000255|PROSITE-ProRule:PRU00463}.
FT   MOD_RES      22     22       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P07507}.
FT   MOD_RES      25     25       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P07507}.
FT   MOD_RES      28     28       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P07507}.
FT   MOD_RES      56     56       4-carboxyglutamate.
FT                                {ECO:0000250|UniProtKB:P07507,
FT                                ECO:0000255|PROSITE-ProRule:PRU00463}.
FT   MOD_RES      60     60       4-carboxyglutamate.
FT                                {ECO:0000250|UniProtKB:P07507,
FT                                ECO:0000255|PROSITE-ProRule:PRU00463}.
FT   MOD_RES      67     67       4-carboxyglutamate.
FT                                {ECO:0000250|UniProtKB:P07507,
FT                                ECO:0000255|PROSITE-ProRule:PRU00463}.
FT   MOD_RES      71     71       4-carboxyglutamate.
FT                                {ECO:0000250|UniProtKB:P07507,
FT                                ECO:0000255|PROSITE-ProRule:PRU00463}.
FT   DISULFID     73     79       {ECO:0000255|PROSITE-ProRule:PRU00463}.
SQ   SEQUENCE   103 AA;  12142 MW;  C140BAB8C4249BC9 CRC64;
     MKSLLLLSVL AALAVAALCY ESHESLESYE INPFLNRRNA NTFISPQQRW RAKAQERIRE
     LNKPPYELNR EACDDYKLCE RYAMVYGYNA AYNRYFRQRP GAK
//
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