ID IQUB_HUMAN Reviewed; 791 AA.
AC Q8NA54; A4D0X0; Q49AL6; Q4G189; Q5BJD9; Q6NUH6; Q8N9Y2;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 27-MAR-2024, entry version 153.
DE RecName: Full=IQ motif and ubiquitin-like domain-containing protein;
GN Name=IQUB;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP MET-126.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH ZMYND10.
RX PubMed=29601588; DOI=10.1371/journal.pgen.1007316;
RA Cho K.J., Noh S.H., Han S.M., Choi W.I., Kim H.Y., Yu S., Lee J.S.,
RA Rim J.H., Lee M.G., Hildebrandt F., Gee H.Y.;
RT "ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-
RT assembly of dynein arms.";
RL PLoS Genet. 14:E1007316-E1007316(2018).
RN [5]
RP STRUCTURE BY NMR OF 121-227.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the novel identified ubiquitin-like domain in the
RT human hypothetical protein FLJ35834.";
RL Submitted (JUN-2006) to the PDB data bank.
RN [6]
RP VARIANT [LARGE SCALE ANALYSIS] HIS-735.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
RN [7]
RP VARIANT 314-TYR--HIS-791 DEL, FUNCTION, INTERACTION WITH RSPH3 AND
RP CALMODULIN, AND INVOLVEMENT IN SPERMATOGENIC FAILURE WITH RADIAL SPOKE
RP DEFECTS.
RX PubMed=36355624; DOI=10.1093/humrep/deac244;
RA Zhang Z., Zhou H., Deng X., Zhang R., Qu R., Mu J., Liu R., Zeng Y.,
RA Chen B., Wang L., Sang Q., Bao S.;
RT "IQUB deficiency causes male infertility by affecting the activity of p-
RT ERK1/2/RSPH3.";
RL Hum. Reprod. 37:deac244-deac244(2022).
CC -!- FUNCTION: Adapter protein that anchors the radial spoke 1 (RS1) complex
CC to the A microtubule of outer doublet microtubules in axonemes
CC (PubMed:36355624). The triple radial spokes (RS1, RS2 and RS3) are
CC required to modulate beating of the sperm flagellum (PubMed:36355624).
CC May play a role in inhibiting signaling via MAPK1/ERK2 and MAPK3/ERK1
CC (PubMed:36355624). Additionally, may play a role in the functioning of
CC cilia (By similarity). Not required for the functioning of tracheal or
CC ependymal cilia (By similarity). {ECO:0000250|UniProtKB:Q8CDK3,
CC ECO:0000269|PubMed:36355624}.
CC -!- SUBUNIT: Component of the axonemal radial spoke 1 (RS1) complex, at
CC least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the
CC cilia-specific component RSPH4A or sperm-specific component RSPH6A,
CC spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the
CC anchor protein IQUB (By similarity). Does not appear to be part of
CC radial spoke complexes 2 or 3 (RS2 or RS3) (By similarity). Interacts
CC with CALM1 (By similarity). Interacts with DNAJB13 (By similarity).
CC Interacts with DYNLL2 (By similarity). Interacts with NME5 (By
CC similarity). Interacts with RSPH3 (PubMed:36355624). Interacts with
CC RSPH9 (By similarity). Interacts with ZMYND10 (PubMed:29601588).
CC Interacts with calmodulin; the interaction occurs in conditions of low
CC but not high calcium (PubMed:36355624). {ECO:0000250|UniProtKB:Q8CDK3,
CC ECO:0000269|PubMed:29601588, ECO:0000269|PubMed:36355624}.
CC -!- INTERACTION:
CC Q8NA54; Q9H161: ALX4; NbExp=3; IntAct=EBI-10220600, EBI-11317841;
CC Q8NA54; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-10220600, EBI-12224467;
CC Q8NA54; Q86SG2: ANKRD23; NbExp=3; IntAct=EBI-10220600, EBI-5661893;
CC Q8NA54; Q9H2G9: BLZF1; NbExp=6; IntAct=EBI-10220600, EBI-2548012;
CC Q8NA54; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-10220600, EBI-739580;
CC Q8NA54; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-10220600, EBI-739624;
CC Q8NA54; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-10220600, EBI-742887;
CC Q8NA54; P28329-3: CHAT; NbExp=3; IntAct=EBI-10220600, EBI-25837549;
CC Q8NA54; Q96A83-2: COL26A1; NbExp=3; IntAct=EBI-10220600, EBI-21553822;
CC Q8NA54; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10220600, EBI-3867333;
CC Q8NA54; Q14689-4: DIP2A; NbExp=3; IntAct=EBI-10220600, EBI-12019962;
CC Q8NA54; O75190-2: DNAJB6; NbExp=3; IntAct=EBI-10220600, EBI-12593112;
CC Q8NA54; O14645: DNALI1; NbExp=3; IntAct=EBI-10220600, EBI-395638;
CC Q8NA54; P50570-2: DNM2; NbExp=3; IntAct=EBI-10220600, EBI-10968534;
CC Q8NA54; P63167: DYNLL1; NbExp=3; IntAct=EBI-10220600, EBI-349105;
CC Q8NA54; O00167-2: EYA2; NbExp=3; IntAct=EBI-10220600, EBI-12807776;
CC Q8NA54; P22607: FGFR3; NbExp=3; IntAct=EBI-10220600, EBI-348399;
CC Q8NA54; Q8TB36: GDAP1; NbExp=3; IntAct=EBI-10220600, EBI-11110431;
CC Q8NA54; P14136: GFAP; NbExp=3; IntAct=EBI-10220600, EBI-744302;
CC Q8NA54; Q08379: GOLGA2; NbExp=3; IntAct=EBI-10220600, EBI-618309;
CC Q8NA54; Q6PI77: GPRASP3; NbExp=3; IntAct=EBI-10220600, EBI-11519926;
CC Q8NA54; P06396: GSN; NbExp=3; IntAct=EBI-10220600, EBI-351506;
CC Q8NA54; P01112: HRAS; NbExp=3; IntAct=EBI-10220600, EBI-350145;
CC Q8NA54; P04792: HSPB1; NbExp=3; IntAct=EBI-10220600, EBI-352682;
CC Q8NA54; Q8IYA8: IHO1; NbExp=4; IntAct=EBI-10220600, EBI-8638439;
CC Q8NA54; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-10220600, EBI-1055254;
CC Q8NA54; Q9BW62: KATNAL1; NbExp=3; IntAct=EBI-10220600, EBI-743591;
CC Q8NA54; O60333-2: KIF1B; NbExp=3; IntAct=EBI-10220600, EBI-10975473;
CC Q8NA54; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-10220600, EBI-14069005;
CC Q8NA54; O14901: KLF11; NbExp=3; IntAct=EBI-10220600, EBI-948266;
CC Q8NA54; Q6A162: KRT40; NbExp=3; IntAct=EBI-10220600, EBI-10171697;
CC Q8NA54; O95678: KRT75; NbExp=3; IntAct=EBI-10220600, EBI-2949715;
CC Q8NA54; Q01546: KRT76; NbExp=3; IntAct=EBI-10220600, EBI-2952745;
CC Q8NA54; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10220600, EBI-10172290;
CC Q8NA54; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-10220600, EBI-10172052;
CC Q8NA54; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-10220600, EBI-10176379;
CC Q8NA54; P60329: KRTAP12-4; NbExp=6; IntAct=EBI-10220600, EBI-10176396;
CC Q8NA54; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-10220600, EBI-12039345;
CC Q8NA54; P02545: LMNA; NbExp=3; IntAct=EBI-10220600, EBI-351935;
CC Q8NA54; P43360: MAGEA6; NbExp=3; IntAct=EBI-10220600, EBI-1045155;
CC Q8NA54; Q99750: MDFI; NbExp=3; IntAct=EBI-10220600, EBI-724076;
CC Q8NA54; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-10220600, EBI-11022007;
CC Q8NA54; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-10220600, EBI-10232538;
CC Q8NA54; Q9Y446: PKP3; NbExp=3; IntAct=EBI-10220600, EBI-2880227;
CC Q8NA54; P78424: POU6F2; NbExp=3; IntAct=EBI-10220600, EBI-12029004;
CC Q8NA54; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-10220600, EBI-11320284;
CC Q8NA54; O60260-5: PRKN; NbExp=3; IntAct=EBI-10220600, EBI-21251460;
CC Q8NA54; E9PI22: PRR23D1; NbExp=3; IntAct=EBI-10220600, EBI-23335840;
CC Q8NA54; Q15669: RHOH; NbExp=3; IntAct=EBI-10220600, EBI-1244971;
CC Q8NA54; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-10220600, EBI-396669;
CC Q8NA54; Q8IYX7: SAXO1; NbExp=3; IntAct=EBI-10220600, EBI-3957636;
CC Q8NA54; Q16637: SMN2; NbExp=6; IntAct=EBI-10220600, EBI-395421;
CC Q8NA54; O60504: SORBS3; NbExp=3; IntAct=EBI-10220600, EBI-741237;
CC Q8NA54; Q7Z699: SPRED1; NbExp=6; IntAct=EBI-10220600, EBI-5235340;
CC Q8NA54; Q8N0S2: SYCE1; NbExp=3; IntAct=EBI-10220600, EBI-6872807;
CC Q8NA54; O14656-2: TOR1A; NbExp=3; IntAct=EBI-10220600, EBI-25847109;
CC Q8NA54; Q05BL1: TP53BP2; NbExp=3; IntAct=EBI-10220600, EBI-11952721;
CC Q8NA54; Q12933: TRAF2; NbExp=3; IntAct=EBI-10220600, EBI-355744;
CC Q8NA54; Q9Y4K3: TRAF6; NbExp=3; IntAct=EBI-10220600, EBI-359276;
CC Q8NA54; P36406: TRIM23; NbExp=7; IntAct=EBI-10220600, EBI-740098;
CC Q8NA54; P14373: TRIM27; NbExp=3; IntAct=EBI-10220600, EBI-719493;
CC Q8NA54; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-10220600, EBI-5235829;
CC Q8NA54; Q86XT4: TRIM50; NbExp=3; IntAct=EBI-10220600, EBI-9867283;
CC Q8NA54; Q9BYV2: TRIM54; NbExp=4; IntAct=EBI-10220600, EBI-2130429;
CC Q8NA54; O76024: WFS1; NbExp=3; IntAct=EBI-10220600, EBI-720609;
CC Q8NA54; P52747: ZNF143; NbExp=3; IntAct=EBI-10220600, EBI-2849334;
CC Q8NA54; Q86VK4-3: ZNF410; NbExp=3; IntAct=EBI-10220600, EBI-11741890;
CC Q8NA54; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-10220600, EBI-11035148;
CC Q8NA54; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-10220600, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000250|UniProtKB:Q8CDK3}. Cell projection, cilium
CC {ECO:0000250|UniProtKB:Q8CDK3}. Note=Localizes to the axoneme of sperm
CC cells and the cilia of tracheal epithelial cells.
CC {ECO:0000250|UniProtKB:Q8CDK3}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NA54-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NA54-2; Sequence=VSP_022830, VSP_022831;
CC -!- DISEASE: Note=Defects in IQUB may be the cause of spermatogenic failure
CC with radial spoke defects, leading to asthenospermia and male
CC infertility (PubMed:36355624). Sperm appear largely normal
CC morphologically but with radial spoke defects, and their motility is
CC severely reduced (PubMed:36355624). {ECO:0000269|PubMed:36355624}.
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DR EMBL; AK093153; BAC04074.1; -; mRNA.
DR EMBL; AK093393; BAC04153.1; -; mRNA.
DR EMBL; CH236947; EAL24336.1; -; Genomic_DNA.
DR EMBL; BC026173; AAH26173.1; -; mRNA.
DR EMBL; BC036121; AAH36121.1; -; mRNA.
DR EMBL; BC091520; AAH91520.1; -; mRNA.
DR EMBL; BC128181; AAI28182.1; -; mRNA.
DR CCDS; CCDS5787.1; -. [Q8NA54-1]
DR RefSeq; NP_001269784.1; NM_001282855.1. [Q8NA54-1]
DR RefSeq; NP_001308222.1; NM_001321293.1. [Q8NA54-1]
DR RefSeq; NP_849149.3; NM_178827.4. [Q8NA54-1]
DR RefSeq; XP_005250218.1; XM_005250161.3. [Q8NA54-1]
DR RefSeq; XP_011514135.1; XM_011515833.2. [Q8NA54-1]
DR RefSeq; XP_011514136.1; XM_011515834.2. [Q8NA54-1]
DR RefSeq; XP_016867260.1; XM_017011771.1. [Q8NA54-1]
DR PDB; 2DAF; NMR; -; A=123-227.
DR PDB; 8J07; EM; 4.10 A; c2=1-791.
DR PDBsum; 2DAF; -.
DR PDBsum; 8J07; -.
DR AlphaFoldDB; Q8NA54; -.
DR EMDB; EMD-35888; -.
DR SMR; Q8NA54; -.
DR BioGRID; 127562; 79.
DR ComplexPortal; CPX-8164; Radial spoke complex, flagellar variant.
DR IntAct; Q8NA54; 76.
DR MINT; Q8NA54; -.
DR STRING; 9606.ENSP00000417769; -.
DR iPTMnet; Q8NA54; -.
DR PhosphoSitePlus; Q8NA54; -.
DR BioMuta; IQUB; -.
DR DMDM; 125950212; -.
DR EPD; Q8NA54; -.
DR MassIVE; Q8NA54; -.
DR PaxDb; 9606-ENSP00000417769; -.
DR PeptideAtlas; Q8NA54; -.
DR ProteomicsDB; 72638; -. [Q8NA54-1]
DR ProteomicsDB; 72639; -. [Q8NA54-2]
DR Antibodypedia; 17626; 24 antibodies from 10 providers.
DR DNASU; 154865; -.
DR Ensembl; ENST00000324698.11; ENSP00000324882.6; ENSG00000164675.11. [Q8NA54-1]
DR Ensembl; ENST00000466202.5; ENSP00000417769.1; ENSG00000164675.11. [Q8NA54-1]
DR Ensembl; ENST00000484508.5; ENSP00000417285.1; ENSG00000164675.11. [Q8NA54-2]
DR GeneID; 154865; -.
DR KEGG; hsa:154865; -.
DR MANE-Select; ENST00000324698.11; ENSP00000324882.6; NM_178827.5; NP_849149.3.
DR UCSC; uc003vkn.4; human. [Q8NA54-1]
DR AGR; HGNC:21995; -.
DR CTD; 154865; -.
DR DisGeNET; 154865; -.
DR GeneCards; IQUB; -.
DR HGNC; HGNC:21995; IQUB.
DR HPA; ENSG00000164675; Tissue enriched (testis).
DR MIM; 620557; gene.
DR neXtProt; NX_Q8NA54; -.
DR OpenTargets; ENSG00000164675; -.
DR PharmGKB; PA162392258; -.
DR VEuPathDB; HostDB:ENSG00000164675; -.
DR eggNOG; ENOG502QRQT; Eukaryota.
DR GeneTree; ENSGT00390000014326; -.
DR HOGENOM; CLU_014415_0_0_1; -.
DR InParanoid; Q8NA54; -.
DR OMA; WKYIHLR; -.
DR OrthoDB; 5478818at2759; -.
DR PhylomeDB; Q8NA54; -.
DR TreeFam; TF323180; -.
DR PathwayCommons; Q8NA54; -.
DR SignaLink; Q8NA54; -.
DR BioGRID-ORCS; 154865; 12 hits in 1143 CRISPR screens.
DR ChiTaRS; IQUB; human.
DR EvolutionaryTrace; Q8NA54; -.
DR GenomeRNAi; 154865; -.
DR Pharos; Q8NA54; Tdark.
DR PRO; PR:Q8NA54; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8NA54; Protein.
DR Bgee; ENSG00000164675; Expressed in sperm and 101 other cell types or tissues.
DR ExpressionAtlas; Q8NA54; baseline and differential.
DR Genevisible; Q8NA54; HS.
DR GO; GO:0097729; C:9+2 motile cilium; ISS:UniProtKB.
DR GO; GO:0001669; C:acrosomal vesicle; IBA:GO_Central.
DR GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR GO; GO:0001534; C:radial spoke; ISS:UniProtKB.
DR GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0030317; P:flagellated sperm motility; IMP:UniProtKB.
DR GO; GO:0007618; P:mating; IMP:UniProtKB.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR CDD; cd17061; Ubl_IQUB; 1.
DR InterPro; IPR037695; IQUB.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR21074:SF0; IQ AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR21074; UNCHARACTERIZED; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cell projection; Cilium;
KW Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton; Disease variant;
KW Flagellum; Reference proteome.
FT CHAIN 1..791
FT /note="IQ motif and ubiquitin-like domain-containing
FT protein"
FT /id="PRO_0000274601"
FT DOMAIN 131..207
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT DOMAIN 338..367
FT /note="IQ"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 587..680
FT /note="VPQDPLKFYKKIYFCHSCQLYLPSTEFSVSSTSRRIYRCRNCINLQNEAQKR
FT ESFLKYKCLLQQLYYTEADYEDDSKIAFLMQLQDIQYLTENI -> MGGEYLSMAL
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022830"
FT VAR_SEQ 681..791
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022831"
FT VARIANT 126
FT /note="V -> M (in dbSNP:rs10255061)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030332"
FT VARIANT 314..791
FT /note="Missing (found in a patient with spermatogenic
FT failure with radial spoke defects; binding to RSPH3 and
FT calmodulin is abrogated; dbSNP:rs1418690066)"
FT /evidence="ECO:0000269|PubMed:36355624"
FT /id="VAR_087798"
FT VARIANT 691
FT /note="D -> N (in dbSNP:rs17146009)"
FT /id="VAR_030333"
FT VARIANT 735
FT /note="R -> H (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs1525626)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036291"
FT VARIANT 735
FT /note="R -> P (in dbSNP:rs1525626)"
FT /id="VAR_030334"
FT CONFLICT 4
FT /note="Q -> R (in Ref. 1; BAC04074)"
FT /evidence="ECO:0000305"
FT CONFLICT 252
FT /note="F -> S (in Ref. 1; BAC04074)"
FT /evidence="ECO:0000305"
FT CONFLICT 343
FT /note="I -> T (in Ref. 1; BAC04074)"
FT /evidence="ECO:0000305"
FT STRAND 131..137
FT /evidence="ECO:0007829|PDB:2DAF"
FT TURN 138..140
FT /evidence="ECO:0007829|PDB:2DAF"
FT STRAND 143..148
FT /evidence="ECO:0007829|PDB:2DAF"
FT STRAND 150..152
FT /evidence="ECO:0007829|PDB:2DAF"
FT HELIX 154..165
FT /evidence="ECO:0007829|PDB:2DAF"
FT TURN 169..171
FT /evidence="ECO:0007829|PDB:2DAF"
FT STRAND 172..176
FT /evidence="ECO:0007829|PDB:2DAF"
FT STRAND 179..181
FT /evidence="ECO:0007829|PDB:2DAF"
FT HELIX 187..190
FT /evidence="ECO:0007829|PDB:2DAF"
FT STRAND 197..205
FT /evidence="ECO:0007829|PDB:2DAF"
FT TURN 207..209
FT /evidence="ECO:0007829|PDB:2DAF"
SQ SEQUENCE 791 AA; 92581 MW; 3D16F8BF4BAED522 CRC64;
MSNQQEKYEA QNIVNSTEES DDAFDTVTIP VPSEEPQESD QTEEHESGIE QFSESHAIHV
EEQSDQSFSS LEPDNEQLME EVISPRQVSY TPQHHEKQYA MQRPNDDSLA FLDKIKSVKE
SLQESVEDSL ATVKVVLIPV GQEIVIPFKV DTILKYLKDH FSHLLGIPHS VLQIRYSGKI
LKNNETLVQH GVKPQEIVQV EIFSTNPDLY PVRRIDGLTD VSQIITVTVQ TGLDQYQQVP
VEIVKSDFHK PFLGGFRHKV TGVEYHNAGT QTVPKRIPER LSIFCRDTQT VFQKKNLQQT
TNTTSTQMTN IGVYVSNMTD KLVTPGKYFS AAEYHAQRLK AVIVIQTYYR QWHAKIFVEN
LRRQKSLRLE WETQQELRKI REKEEWIKLD YHRRHNPKTN EDFEFLYNAL EFWRQEELTR
INQSFTGAER KAALCELLEK ETQIIASIGR HRYIAYMANQ EAAIQAFLDK CSAPKIWRTP
NGKTIEMDTQ FTIRARELQN IYKCIMLKNI SQDERLDVLL TLKHTVKEHE CKLTQEILEL
IDREVDLMMR GVKHHNLEGL RKRIATLFFH YIKTPLFNPE VAKYLKVPQD PLKFYKKIYF
CHSCQLYLPS TEFSVSSTSR RIYRCRNCIN LQNEAQKRES FLKYKCLLQQ LYYTEADYED
DSKIAFLMQL QDIQYLTENI WASQSVLSAC DNLSDLVMVR WNKSLEWSPW NCILLTKDEA
AAHLKLTSIE EGYERSFIHK IKHKHILAKN YFSQVPVLAS FILDDGEIDE IRWKYHSDTT
PKIIESQRPP H
//
