ID ZN439_HUMAN Reviewed; 499 AA.
AC Q8NDP4; Q8IYZ7; Q96SU1;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 167.
DE RecName: Full=Zinc finger protein 439;
GN Name=ZNF439;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Substantia nigra;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-499.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-499, AND VARIANT SER-427.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8NDP4; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-747580, EBI-3866279;
CC Q8NDP4; O95273: CCNDBP1; NbExp=3; IntAct=EBI-747580, EBI-748961;
CC Q8NDP4; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-747580, EBI-739624;
CC Q8NDP4; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-747580, EBI-3867333;
CC Q8NDP4; O75496: GMNN; NbExp=7; IntAct=EBI-747580, EBI-371669;
CC Q8NDP4; Q6A162: KRT40; NbExp=6; IntAct=EBI-747580, EBI-10171697;
CC Q8NDP4; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-747580, EBI-11959885;
CC Q8NDP4; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-747580, EBI-10172150;
CC Q8NDP4; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-747580, EBI-10172290;
CC Q8NDP4; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-747580, EBI-10171774;
CC Q8NDP4; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-747580, EBI-10172052;
CC Q8NDP4; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-747580, EBI-11953334;
CC Q8NDP4; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-747580, EBI-3958099;
CC Q8NDP4; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-747580, EBI-1043191;
CC Q8NDP4; Q99750: MDFI; NbExp=8; IntAct=EBI-747580, EBI-724076;
CC Q8NDP4; Q5JR59: MTUS2; NbExp=4; IntAct=EBI-747580, EBI-742948;
CC Q8NDP4; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-747580, EBI-11522433;
CC Q8NDP4; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-747580, EBI-945833;
CC Q8NDP4; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-747580, EBI-742388;
CC Q8NDP4; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-747580, EBI-725997;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB55187.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL833935; CAD38790.1; -; mRNA.
DR EMBL; AK027542; BAB55187.1; ALT_INIT; mRNA.
DR EMBL; BC032857; AAH32857.1; -; mRNA.
DR CCDS; CCDS12268.1; -.
DR RefSeq; NP_001335653.1; NM_001348724.1.
DR RefSeq; NP_001335654.1; NM_001348725.1.
DR RefSeq; NP_689475.1; NM_152262.2.
DR AlphaFoldDB; Q8NDP4; -.
DR SMR; Q8NDP4; -.
DR BioGRID; 124741; 23.
DR IntAct; Q8NDP4; 23.
DR MINT; Q8NDP4; -.
DR STRING; 9606.ENSP00000305077; -.
DR iPTMnet; Q8NDP4; -.
DR PhosphoSitePlus; Q8NDP4; -.
DR BioMuta; ZNF439; -.
DR DMDM; 30580628; -.
DR jPOST; Q8NDP4; -.
DR MassIVE; Q8NDP4; -.
DR MaxQB; Q8NDP4; -.
DR PaxDb; 9606-ENSP00000305077; -.
DR PeptideAtlas; Q8NDP4; -.
DR ProteomicsDB; 73047; -.
DR Antibodypedia; 53866; 18 antibodies from 8 providers.
DR DNASU; 90594; -.
DR Ensembl; ENST00000304030.2; ENSP00000305077.2; ENSG00000171291.9.
DR GeneID; 90594; -.
DR KEGG; hsa:90594; -.
DR UCSC; uc002msr.4; human.
DR AGR; HGNC:20873; -.
DR GeneCards; ZNF439; -.
DR HGNC; HGNC:20873; ZNF439.
DR HPA; ENSG00000171291; Low tissue specificity.
DR neXtProt; NX_Q8NDP4; -.
DR OpenTargets; ENSG00000171291; -.
DR PharmGKB; PA134886330; -.
DR VEuPathDB; HostDB:ENSG00000171291; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163273; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q8NDP4; -.
DR OMA; QIHENTH; -.
DR OrthoDB; 4667724at2759; -.
DR PhylomeDB; Q8NDP4; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q8NDP4; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8NDP4; -.
DR BioGRID-ORCS; 90594; 5 hits in 1096 CRISPR screens.
DR ChiTaRS; ZNF439; human.
DR GenomeRNAi; 90594; -.
DR Pharos; Q8NDP4; Tdark.
DR PRO; PR:Q8NDP4; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NDP4; Protein.
DR Bgee; ENSG00000171291; Expressed in cortical plate and 131 other cell types or tissues.
DR ExpressionAtlas; Q8NDP4; baseline and differential.
DR Genevisible; Q8NDP4; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 12.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF148; ZINC FINGER IMPRINTED 2; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..499
FT /note="Zinc finger protein 439"
FT /id="PRO_0000047588"
FT DOMAIN 19..101
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 186..208
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 214..236
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 242..264
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 270..292
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 298..320
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..348
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 354..376
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 382..404
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 410..432
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 438..460
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 466..490
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 6
FT /note="P -> S (in dbSNP:rs10421552)"
FT /id="VAR_052827"
FT VARIANT 427
FT /note="L -> S (in dbSNP:rs10500209)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024216"
SQ SEQUENCE 499 AA; 58395 MW; 483E3238E280F229 CRC64;
MLSLSPILLY TCEMFQDPVA FKDVAVNFTQ EEWALLDISQ KNLYREVMLE TFWNLTSIGK
KWKDQNIEYE YQNPRRNFRS VTEEKVNEIK EDSHCGETFT PVPDDRLNFQ KKKASPEVKS
CDSFVCEVGL GNSSSNMNIR GDTGHKACEC QEYGPKPWKS QQPKKAFRYH PSLRTQERDH
TGKKPYACKE CGKNIIYHSS IQRHMVVHSG DGPYKCKFCG KAFHCLSLYL IHERTHTGEK
PYECKQCGKS FSYSATHRIH ERTHIGEKPY ECQECGKAFH SPRSCHRHER SHMGEKAYQC
KECGKAFMCP RYVRRHERTH SRKKLYECKQ CGKALSSLTS FQTHIRMHSG ERPYECKTCG
KGFYSAKSFQ RHEKTHSGEK PYKCKQCGKA FTRSGSFRYH ERTHTGEKPY ECKQCGKAFR
SAPNLQLHGR THTGEKPYQC KECGKAFRSA SQLRIHRRIH TGEKPYECKK CGKAFRYVQN
FRFHERTQTH KNALWRKTL
//
