GenomeNet

Database: UniProt
Entry: Q8NDW8
LinkDB: Q8NDW8
Original site: Q8NDW8 
ID   TT21A_HUMAN             Reviewed;        1320 AA.
AC   Q8NDW8; A1L388; B4DYF6; B4DYJ3; D3YTE7; D4PHA5; Q6P5W8; Q8N7G5; Q8NA02;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 3.
DT   11-DEC-2019, entry version 141.
DE   RecName: Full=Tetratricopeptide repeat protein 21A {ECO:0000303|PubMed:30929735};
DE            Short=TPR repeat protein 21A {ECO:0000303|PubMed:30929735};
DE   AltName: Full=Stress-inducible protein 2 {ECO:0000303|PubMed:12543795};
GN   Name=TTC21A {ECO:0000303|PubMed:30929735, ECO:0000312|HGNC:HGNC:30761};
GN   Synonyms=STI2 {ECO:0000303|PubMed:12543795};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANT
RP   LYS-1316.
RC   TISSUE=Pancreas;
RX   PubMed=12543795;
RA   Protopopov A., Kashuba V., Zabarovska V.I., Muravenko O.V., Lerman M.I.,
RA   Klein G., Zabarovsky E.R.;
RT   "An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20)
RT   region implicated in major human epithelial malignancies.";
RL   Cancer Res. 63:404-412(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF
RP   440-1320 (ISOFORMS 5/6/7), AND VARIANT LEU-1055.
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [4]
RP   INVOLVEMENT IN SPGF37, VARIANTS SPGF37 CYS-114 AND 777-GLN--PRO-1320 DEL,
RP   FUNCTION, DEVELOPMENTAL STAGE, AND INTERACTION WITH IFT20; IFT52 AND
RP   IFT140.
RX   PubMed=30929735; DOI=10.1016/j.ajhg.2019.02.020;
RA   Liu W., He X., Yang S., Zouari R., Wang J., Wu H., Kherraf Z.E., Liu C.,
RA   Coutton C., Zhao R., Tang D., Tang S., Lv M., Fang Y., Li W., Li H.,
RA   Zhao J., Wang X., Zhao S., Zhang J., Arnoult C., Jin L., Zhang Z.,
RA   Ray P.F., Cao Y., Zhang F.;
RT   "Bi-allelic mutations in TTC21A induce asthenoteratospermia in humans and
RT   mice.";
RL   Am. J. Hum. Genet. 104:738-748(2019).
CC   -!- FUNCTION: Intraflagellar transport (IFT)-associated protein required
CC       for spermatogenesis (PubMed:30929735). Required for sperm flagellar
CC       formation and intraflagellar transport (PubMed:30929735).
CC       {ECO:0000269|PubMed:30929735}.
CC   -!- SUBUNIT: Interacts with IFT20 (PubMed:30929735). Interacts with IFT52
CC       (PubMed:30929735). Interacts with IFT140 (PubMed:30929735).
CC       {ECO:0000269|PubMed:30929735}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=5;
CC       Name=1;
CC         IsoId=Q8NDW8-1; Sequence=Displayed;
CC       Name=3;
CC         IsoId=Q8NDW8-3; Sequence=VSP_026297;
CC       Name=5;
CC         IsoId=Q8NDW8-5; Sequence=VSP_038429, VSP_038430, VSP_038431;
CC       Name=6;
CC         IsoId=Q8NDW8-6; Sequence=VSP_038428, VSP_038429, VSP_038431;
CC       Name=7;
CC         IsoId=Q8NDW8-7; Sequence=VSP_038431;
CC   -!- TISSUE SPECIFICITY: Strongly expressed in testis.
CC       {ECO:0000269|PubMed:12543795}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in preleptotene spermatocytes, pachytene
CC       spermatocytes, round spermatids and elongated spermatids (at protein
CC       level). {ECO:0000269|PubMed:30929735}.
CC   -!- DISEASE: Spermatogenic failure 37 (SPGF37) [MIM:618429]: An autosomal
CC       recessive infertility disorder characterized by
CC       asthenoteratozoospermia. Spermatozoa exhibit multiple morphologic
CC       abnormalities, primarily consisting of short or absent flagella, and
CC       neck defects at the head-tail junction. {ECO:0000269|PubMed:30929735}.
CC       Note=The disease is caused by mutations affecting the gene represented
CC       in this entry.
CC   -!- SIMILARITY: Belongs to the TTC21 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC04129.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
DR   EMBL; AJ487015; CAD31647.1; -; mRNA.
DR   EMBL; AK093313; BAC04129.1; ALT_INIT; mRNA.
DR   EMBL; AK098528; BAC05323.1; -; mRNA.
DR   EMBL; AK302408; BAG63718.1; -; mRNA.
DR   EMBL; AK302465; BAG63755.1; -; mRNA.
DR   EMBL; AC092053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC138124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS43068.2; -. [Q8NDW8-6]
DR   CCDS; CCDS46800.1; -. [Q8NDW8-1]
DR   RefSeq; NP_001098983.2; NM_001105513.2. [Q8NDW8-6]
DR   RefSeq; NP_665698.2; NM_145755.2. [Q8NDW8-1]
DR   BioGrid; 128260; 8.
DR   IntAct; Q8NDW8; 4.
DR   STRING; 9606.ENSP00000398211; -.
DR   iPTMnet; Q8NDW8; -.
DR   PhosphoSitePlus; Q8NDW8; -.
DR   BioMuta; TTC21A; -.
DR   DMDM; 296453007; -.
DR   jPOST; Q8NDW8; -.
DR   MassIVE; Q8NDW8; -.
DR   PaxDb; Q8NDW8; -.
DR   PeptideAtlas; Q8NDW8; -.
DR   PRIDE; Q8NDW8; -.
DR   ProteomicsDB; 73070; -. [Q8NDW8-1]
DR   ProteomicsDB; 73071; -. [Q8NDW8-3]
DR   ProteomicsDB; 73072; -. [Q8NDW8-5]
DR   ProteomicsDB; 73073; -. [Q8NDW8-6]
DR   ProteomicsDB; 73074; -. [Q8NDW8-7]
DR   TopDownProteomics; Q8NDW8-6; -. [Q8NDW8-6]
DR   Ensembl; ENST00000431162; ENSP00000398211; ENSG00000168026. [Q8NDW8-1]
DR   Ensembl; ENST00000440121; ENSP00000410882; ENSG00000168026. [Q8NDW8-6]
DR   GeneID; 199223; -.
DR   KEGG; hsa:199223; -.
DR   UCSC; uc003cjc.3; human. [Q8NDW8-1]
DR   CTD; 199223; -.
DR   EuPathDB; HostDB:ENSG00000168026.16; -.
DR   GeneCards; TTC21A; -.
DR   HGNC; HGNC:30761; TTC21A.
DR   HPA; HPA035510; -.
DR   HPA; HPA035511; -.
DR   MalaCards; TTC21A; -.
DR   MIM; 611430; gene.
DR   MIM; 618429; phenotype.
DR   neXtProt; NX_Q8NDW8; -.
DR   OpenTargets; ENSG00000168026; -.
DR   Orphanet; 276234; Non-syndromic male infertility due to sperm motility disorder.
DR   PharmGKB; PA134915959; -.
DR   eggNOG; ENOG410IEX1; Eukaryota.
DR   eggNOG; ENOG410XV69; LUCA.
DR   GeneTree; ENSGT00390000005979; -.
DR   InParanoid; Q8NDW8; -.
DR   OMA; AQIYLAQ; -.
DR   OrthoDB; 45918at2759; -.
DR   PhylomeDB; Q8NDW8; -.
DR   TreeFam; TF314664; -.
DR   ChiTaRS; TTC21A; human.
DR   GenomeRNAi; 199223; -.
DR   Pharos; Q8NDW8; Tdark.
DR   PRO; PR:Q8NDW8; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q8NDW8; protein.
DR   Bgee; ENSG00000168026; Expressed in 122 organ(s), highest expression level in right uterine tube.
DR   ExpressionAtlas; Q8NDW8; baseline and differential.
DR   Genevisible; Q8NDW8; HS.
DR   GO; GO:0005929; C:cilium; IEA:GOC.
DR   GO; GO:0030991; C:intraciliary transport particle A; IBA:GO_Central.
DR   GO; GO:0030317; P:flagellated sperm motility; IMP:UniProtKB.
DR   GO; GO:0035721; P:intraciliary retrograde transport; IBA:GO_Central.
DR   GO; GO:0061512; P:protein localization to cilium; IBA:GO_Central.
DR   GO; GO:0007286; P:spermatid development; IMP:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR013026; TPR-contain_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR040364; TTC21A/TTC21B.
DR   PANTHER; PTHR14699; PTHR14699; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 13.
DR   SUPFAM; SSF48452; SSF48452; 4.
DR   PROSITE; PS50005; TPR; 9.
DR   PROSITE; PS50293; TPR_REGION; 4.
PE   1: Evidence at protein level;
KW   Alternative splicing; Differentiation; Disease mutation; Polymorphism;
KW   Reference proteome; Repeat; Spermatogenesis; TPR repeat.
FT   CHAIN           1..1320
FT                   /note="Tetratricopeptide repeat protein 21A"
FT                   /id="PRO_0000291915"
FT   REPEAT          4..38
FT                   /note="TPR 1"
FT   REPEAT          110..143
FT                   /note="TPR 2"
FT   REPEAT          146..180
FT                   /note="TPR 3"
FT   REPEAT          181..213
FT                   /note="TPR 4"
FT   REPEAT          215..247
FT                   /note="TPR 5"
FT   REPEAT          334..367
FT                   /note="TPR 6"
FT   REPEAT          502..534
FT                   /note="TPR 7"
FT   REPEAT          572..605
FT                   /note="TPR 8"
FT   REPEAT          728..761
FT                   /note="TPR 9"
FT   REPEAT          762..795
FT                   /note="TPR 10"
FT   REPEAT          797..828
FT                   /note="TPR 11"
FT   REPEAT          837..869
FT                   /note="TPR 12"
FT   REPEAT          889..922
FT                   /note="TPR 13"
FT   REPEAT          924..956
FT                   /note="TPR 14"
FT   REPEAT          957..990
FT                   /note="TPR 15"
FT   REPEAT          1028..1061
FT                   /note="TPR 16"
FT   REPEAT          1201..1234
FT                   /note="TPR 17"
FT   REPEAT          1236..1268
FT                   /note="TPR 18"
FT   REPEAT          1270..1303
FT                   /note="TPR 19"
FT   VAR_SEQ         1..879
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_026297"
FT   VAR_SEQ         147..187
FT                   /note="Missing (in isoform 6)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_038428"
FT   VAR_SEQ         268..275
FT                   /note="Missing (in isoform 5 and isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_038429"
FT   VAR_SEQ         386..396
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_038430"
FT   VAR_SEQ         515
FT                   /note="S -> SG (in isoform 5, isoform 6 and isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_038431"
FT   VARIANT         91
FT                   /note="R -> Q (in dbSNP:rs1112438)"
FT                   /id="VAR_032879"
FT   VARIANT         108
FT                   /note="V -> L (in dbSNP:rs17855763)"
FT                   /id="VAR_032880"
FT   VARIANT         114
FT                   /note="Y -> C (in SPGF37; dbSNP:rs750057655)"
FT                   /evidence="ECO:0000269|PubMed:30929735"
FT                   /id="VAR_082207"
FT   VARIANT         290
FT                   /note="R -> K (in dbSNP:rs1274972)"
FT                   /id="VAR_032881"
FT   VARIANT         293
FT                   /note="E -> K (in dbSNP:rs1274971)"
FT                   /id="VAR_032882"
FT   VARIANT         622
FT                   /note="R -> W (in dbSNP:rs35581078)"
FT                   /id="VAR_032883"
FT   VARIANT         719
FT                   /note="R -> H (in dbSNP:rs9861353)"
FT                   /id="VAR_059861"
FT   VARIANT         719
FT                   /note="R -> Q (in dbSNP:rs9861353)"
FT                   /id="VAR_032884"
FT   VARIANT         777..1320
FT                   /note="Missing (in SPGF37)"
FT                   /evidence="ECO:0000269|PubMed:30929735"
FT                   /id="VAR_082208"
FT   VARIANT         1055
FT                   /note="R -> L (in dbSNP:rs35934336)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_032885"
FT   VARIANT         1160
FT                   /note="S -> R (in dbSNP:rs34201693)"
FT                   /id="VAR_032886"
FT   VARIANT         1316
FT                   /note="R -> K (in dbSNP:rs704959)"
FT                   /evidence="ECO:0000269|PubMed:12543795"
FT                   /id="VAR_032887"
FT   CONFLICT        153
FT                   /note="V -> G (in Ref. 1; CAD31647)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        174
FT                   /note="I -> T (in Ref. 2; BAG63718)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        802
FT                   /note="G -> D (in Ref. 2; BAG63755)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        803
FT                   /note="K -> E (in Ref. 1; CAD31647)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        838
FT                   /note="K -> R (in Ref. 2; BAG63718)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1095
FT                   /note="M -> T (in Ref. 1; CAD31647)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1165
FT                   /note="L -> P (in Ref. 2; BAC04129)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1291
FT                   /note="E -> K (in Ref. 2; BAG63755)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1320 AA;  150944 MW;  CFB949A8E2B702DE CRC64;
     MSSNDSSLMA GIIYYSQEKY FHHVQQAAAV GLEKFSNDPV LKFFKAYGVL KEEHIQDAIS
     DLESIRHHPD VSLCSTMALI YAHKRCEIID REAIQELEYS LKEIRKTVSG TALYYAGLFL
     WLIGRHDKAK EYIDRMLKIS RGFREAYVLR GWVDLTSDKP HTAKKAIEYL EQGIQDTKDV
     LGLMGKAMYF MMQQNYSEAL EVVNQITVTS GSFLPALVLK MQLFLARQDW EQTVEMGHRI
     LEKDESNIDA CQILTVHELA REGNMTTVSS LKTQKATNHV RNLIKALETR EPENPSLHLK
     KIIVVSRLCG SHQVILGLVC SFIERTFMAT PSYVHVATEL GYLFILKNQV KEALLWYSEA
     MKLDKDGMAG LTGIILCHIL EGHLEEAEYR LEFLKEVQKS LGKSEVLIFL QALLMSRKHK
     GEEETTALLK EAVELHFSSM QGIPLGSEYF EKLDPYFLVC IAKEYLLFCP KQPRLPGQIV
     SPLLKQVAVI LNPVVKAAPA LIDPLYLMAQ VRYYSELENA QSILQRCLEL DPASVDAHLL
     MCQIYLAQGN FGMCFHCLEL GVSHNFQVRD HPLYHLIKAR ALNKAGDYPE AIKTLKMVIK
     LPALKKEEGR KFLRPSVQPS QRASILLELV EALRLNGELH EATKVMQDTI NEFGGTPEEN
     RITIANVDLV LSKGNVDVAL NMLRNILPKQ SCYMEAREKM ANIYLQTLRD RRLYIRCYRE
     LCEHLPGPHT SLLLGDALMS ILEPEKALEV YDEAYRQNPH DASLASRIGH AYVKAHQYTE
     AIEYYEAAQK INGQDFLCCD LGKLLLKLKK VNKAEKVLKQ ALEHDIVQDI PSMMNDVKCL
     LLLAKVYKSH KKEAVIETLN KALDLQSRIL KRVPLEQPEM IPSQKQLAAS ICIQFAEHYL
     AEKEYDKAVQ SYKDVFSYLP TDNKVMLELA QLYLLQGHLD LCEQHCAILL QTEQNHETAS
     VLMADLMFRK QKHEAAINLY HQVLEKAPDN FLVLHKLIDL LRRSGKLEDI PAFFELAKKV
     SSRVPLEPGF NYCRGIYCWH IGQPNEALKF LNKARKDSTW GQSAIYHMVQ ICLNPDNEVV
     GGEAFENQGA ESNYMEKKEL EQQGVSTAEK LLREFYPHSD SSQTQLRLLQ GLCRLATREK
     ANMEAALGSF IQIAQAEKDS VPALLALAQA YVFLKQIPKA RMQLKRLAKT PWVLSEAEDL
     EKSWLLLADI YCQGSKFDLA LELLRRCVQY NKSCYKAYEY MGFIMEKEQS YKDAVTNYKL
     AWKYSHHANP AIGFKLAFNY LKDKKFVEAI EICNDVLREH PDYPKIREEI LEKARRSLRP
//
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