GenomeNet

Database: UniProt
Entry: Q8NEY1
LinkDB: Q8NEY1
Original site: Q8NEY1 
ID   NAV1_HUMAN              Reviewed;        1877 AA.
AC   Q8NEY1; A8MS88; Q5SVH1; Q5SVH2; Q5SVH3; Q5SVH7; Q5VUY9; Q8IVL2; Q96II1;
AC   Q9H7V9; Q9H9S9; Q9H9T5; Q9UGI1; Q9ULK7; Q9ULR9;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 2.
DT   12-AUG-2020, entry version 157.
DE   RecName: Full=Neuron navigator 1;
DE   AltName: Full=Pore membrane and/or filament-interacting-like protein 3;
DE   AltName: Full=Steerin-1;
DE   AltName: Full=Unc-53 homolog 1;
DE            Short=unc53H1;
GN   Name=NAV1; Synonyms=KIAA1151, KIAA1213, POMFIL3, STEERIN1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=12062803; DOI=10.1016/s0378-1119(02)00567-x;
RA   Coy J.F., Wiemann S., Bechmann I., Baechner D., Nitsch R., Kretz O.,
RA   Christiansen H., Poustka A.;
RT   "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is
RT   predominantly expressed in the nervous system and encodes different protein
RT   isoforms.";
RL   Gene 290:73-94(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-1273, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=12079279; DOI=10.1006/geno.2002.6799;
RA   Maes T., Barcelo A., Buesa C.;
RT   "Neuron navigator: a human gene family with homology to unc-53, a cell
RT   guidance gene from Caenorhabditis elegans.";
RL   Genomics 80:21-30(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-409, AND NUCLEOTIDE SEQUENCE [MRNA]
RP   OF 42-1877 (ISOFORM 1).
RX   PubMed=15158073; DOI=10.1016/j.devbrainres.2004.03.004;
RA   Peeters P.J., Baker A., Goris I., Daneels G., Verhasselt P.,
RA   Luyten W.H.M.L., Geysen J.J.G.H., Kass S.U., Moechars D.W.E.;
RT   "Sensory deficits in mice hypomorphic for a mammalian homologue of unc-
RT   53.";
RL   Brain Res. Dev. Brain Res. 150:89-101(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 108-1877 (ISOFORM 1), AND
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 707-1877 (ISOFORM 6).
RC   TISSUE=Brain;
RX   PubMed=10574461; DOI=10.1093/dnares/6.5.329;
RA   Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.;
RT   "Characterization of cDNA clones selected by the GeneMark analysis from
RT   size-fractionated cDNA libraries from human brain.";
RL   DNA Res. 6:329-336(1999).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 445-1205 (ISOFORM 2), AND
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1161-1877 (ISOFORM 3).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1122-1877 (ISOFORM 3).
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152; THR-159; SER-199;
RP   SER-296; SER-308; SER-391; SER-452; THR-534; THR-572; SER-760; SER-808;
RP   THR-1170; SER-1181 AND SER-1382, AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [9]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT   refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
RN   [10]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-750, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19369195; DOI=10.1074/mcp.m800588-mcp200;
RA   Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA   Mann M., Daub H.;
RT   "Large-scale proteomics analysis of the human kinome.";
RL   Mol. Cell. Proteomics 8:1751-1764(2009).
RN   [11]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; SER-362; SER-452;
RP   SER-808; SER-1000; THR-1006 AND SER-1265, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [12]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [13]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; SER-142 AND SER-760, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA   Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT   "System-wide temporal characterization of the proteome and phosphoproteome
RT   of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:RS3-RS3(2011).
RN   [14]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN   [15]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; SER-142; SER-194;
RP   SER-199; SER-312; SER-391; SER-452; SER-474; SER-476; SER-490; SER-528;
RP   SER-541; THR-544; SER-648; SER-754; SER-760; SER-797; SER-808; SER-1000 AND
RP   SER-1265, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [16]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- FUNCTION: May be involved in neuronal migration. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with tubulin. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8NEY1-3; Q96D03: DDIT4L; NbExp=5; IntAct=EBI-11953718, EBI-742054;
CC       Q8NEY1-3; Q96CN9: GCC1; NbExp=3; IntAct=EBI-11953718, EBI-746252;
CC       Q8NEY1-3; Q15323: KRT31; NbExp=3; IntAct=EBI-11953718, EBI-948001;
CC       Q8NEY1-3; Q96LW4: PRIMPOL; NbExp=5; IntAct=EBI-11953718, EBI-10044038;
CC       Q8NEY1-3; Q7L4I2: RSRC2; NbExp=3; IntAct=EBI-11953718, EBI-953753;
CC       Q8NEY1-4; Q96CN9: GCC1; NbExp=3; IntAct=EBI-10270828, EBI-746252;
CC       Q8NEY1-4; Q15323: KRT31; NbExp=3; IntAct=EBI-10270828, EBI-948001;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC       Note=Associates with a subset of microtubule plus ends. Enriched in
CC       neuronal growth cones (By similarity). {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=7;
CC       Name=1;
CC         IsoId=Q8NEY1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8NEY1-2; Sequence=VSP_025256;
CC       Name=3;
CC         IsoId=Q8NEY1-3; Sequence=VSP_025259;
CC       Name=4;
CC         IsoId=Q8NEY1-4; Sequence=VSP_025255, VSP_025259;
CC       Name=5;
CC         IsoId=Q8NEY1-5; Sequence=VSP_025253, VSP_025254, VSP_025259;
CC       Name=6;
CC         IsoId=Q8NEY1-6; Sequence=VSP_025256, VSP_025257, VSP_025258;
CC       Name=7;
CC         IsoId=Q8NEY1-7; Sequence=VSP_025255, VSP_025256, VSP_025259;
CC   -!- TISSUE SPECIFICITY: Broadly expressed at low levels. Expressed at high
CC       levels in heart, skeletal muscle and placenta.
CC       {ECO:0000269|PubMed:12062803, ECO:0000269|PubMed:12079279}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in fetal brain and heart.
CC       {ECO:0000269|PubMed:12062803}.
CC   -!- SIMILARITY: Belongs to the Nav/unc-53 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH07523.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB14136.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB14142.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB14865.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; AY043013; AAL05591.1; -; mRNA.
DR   EMBL; AC092800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL512788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL645504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC096677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJ251973; CAB66088.1; -; Genomic_DNA.
DR   EMBL; AJ488101; CAD32470.1; -; mRNA.
DR   EMBL; AB032977; BAA86465.3; -; mRNA.
DR   EMBL; AB033039; BAA86527.1; -; mRNA.
DR   EMBL; AK022622; BAB14136.1; ALT_INIT; mRNA.
DR   EMBL; AK022631; BAB14142.1; ALT_INIT; mRNA.
DR   EMBL; AK024265; BAB14865.1; ALT_INIT; mRNA.
DR   EMBL; BC007523; AAH07523.1; ALT_INIT; mRNA.
DR   CCDS; CCDS1414.2; -. [Q8NEY1-1]
DR   CCDS; CCDS53456.1; -. [Q8NEY1-5]
DR   RefSeq; NP_001161210.1; NM_001167738.1. [Q8NEY1-5]
DR   RefSeq; NP_065176.3; NM_020443.4. [Q8NEY1-1]
DR   RefSeq; XP_011508399.1; XM_011510097.1.
DR   RefSeq; XP_011508400.1; XM_011510098.1.
DR   RefSeq; XP_011508404.1; XM_011510102.1.
DR   RefSeq; XP_016858240.1; XM_017002751.1.
DR   BioGRID; 124605; 70.
DR   IntAct; Q8NEY1; 30.
DR   MINT; Q8NEY1; -.
DR   STRING; 9606.ENSP00000356265; -.
DR   CarbonylDB; Q8NEY1; -.
DR   iPTMnet; Q8NEY1; -.
DR   PhosphoSitePlus; Q8NEY1; -.
DR   BioMuta; NAV1; -.
DR   DMDM; 147704557; -.
DR   EPD; Q8NEY1; -.
DR   jPOST; Q8NEY1; -.
DR   MassIVE; Q8NEY1; -.
DR   MaxQB; Q8NEY1; -.
DR   PaxDb; Q8NEY1; -.
DR   PeptideAtlas; Q8NEY1; -.
DR   PRIDE; Q8NEY1; -.
DR   ProteomicsDB; 73230; -. [Q8NEY1-1]
DR   ProteomicsDB; 73231; -. [Q8NEY1-2]
DR   ProteomicsDB; 73232; -. [Q8NEY1-3]
DR   ProteomicsDB; 73233; -. [Q8NEY1-4]
DR   ProteomicsDB; 73234; -. [Q8NEY1-5]
DR   ProteomicsDB; 73235; -. [Q8NEY1-6]
DR   ProteomicsDB; 73236; -. [Q8NEY1-7]
DR   Antibodypedia; 3226; 68 antibodies.
DR   DNASU; 89796; -.
DR   Ensembl; ENST00000367295; ENSP00000356264; ENSG00000134369. [Q8NEY1-5]
DR   Ensembl; ENST00000367296; ENSP00000356265; ENSG00000134369. [Q8NEY1-1]
DR   GeneID; 89796; -.
DR   KEGG; hsa:89796; -.
DR   UCSC; uc001gwx.4; human. [Q8NEY1-1]
DR   CTD; 89796; -.
DR   DisGeNET; 89796; -.
DR   EuPathDB; HostDB:ENSG00000134369.15; -.
DR   GeneCards; NAV1; -.
DR   HGNC; HGNC:15989; NAV1.
DR   HPA; ENSG00000134369; Low tissue specificity.
DR   MIM; 611628; gene.
DR   neXtProt; NX_Q8NEY1; -.
DR   OpenTargets; ENSG00000134369; -.
DR   PharmGKB; PA31451; -.
DR   eggNOG; ENOG502QSUE; Eukaryota.
DR   GeneTree; ENSGT00940000156637; -.
DR   InParanoid; Q8NEY1; -.
DR   KO; K16776; -.
DR   OMA; RTNIQYR; -.
DR   OrthoDB; 21830at2759; -.
DR   PhylomeDB; Q8NEY1; -.
DR   TreeFam; TF329881; -.
DR   PathwayCommons; Q8NEY1; -.
DR   BioGRID-ORCS; 89796; 4 hits in 871 CRISPR screens.
DR   ChiTaRS; NAV1; human.
DR   GeneWiki; NAV1; -.
DR   GenomeRNAi; 89796; -.
DR   Pharos; Q8NEY1; Tdark.
DR   PRO; PR:Q8NEY1; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8NEY1; protein.
DR   Bgee; ENSG00000134369; Expressed in forebrain and 228 other tissues.
DR   ExpressionAtlas; Q8NEY1; baseline and differential.
DR   Genevisible; Q8NEY1; HS.
DR   GO; GO:0043194; C:axon initial segment; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR   GO; GO:0001578; P:microtubule bundle formation; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR   GO; GO:0001764; P:neuron migration; IBA:GO_Central.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR039041; Nav/unc-53.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12784; PTHR12784; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Developmental protein; Differentiation; Methylation; Microtubule;
KW   Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome.
FT   CHAIN           1..1877
FT                   /note="Neuron navigator 1"
FT                   /id="PRO_0000286974"
FT   COILED          255..280
FT                   /evidence="ECO:0000255"
FT   COILED          731..756
FT                   /evidence="ECO:0000255"
FT   COILED          1072..1163
FT                   /evidence="ECO:0000255"
FT   COILED          1303..1362
FT                   /evidence="ECO:0000255"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000244|PubMed:22814378"
FT   MOD_RES         90
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231,
FT                   ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163"
FT   MOD_RES         142
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:21406692,
FT                   ECO:0000244|PubMed:23186163"
FT   MOD_RES         152
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:18669648"
FT   MOD_RES         159
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000244|PubMed:18669648"
FT   MOD_RES         194
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         199
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:18669648,
FT                   ECO:0000244|PubMed:23186163"
FT   MOD_RES         296
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:18669648"
FT   MOD_RES         308
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:18669648"
FT   MOD_RES         312
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         362
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         391
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:18669648,
FT                   ECO:0000244|PubMed:23186163"
FT   MOD_RES         452
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:18669648,
FT                   ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:23186163"
FT   MOD_RES         474
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         476
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         490
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         528
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         534
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000244|PubMed:18669648"
FT   MOD_RES         541
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         544
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         572
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000244|PubMed:18669648"
FT   MOD_RES         648
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         688
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CH77"
FT   MOD_RES         750
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:19369195"
FT   MOD_RES         754
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         760
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:18669648,
FT                   ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163"
FT   MOD_RES         797
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         808
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:18669648,
FT                   ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:23186163"
FT   MOD_RES         1000
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231,
FT                   ECO:0000244|PubMed:23186163"
FT   MOD_RES         1006
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000244|PubMed:20068231"
FT   MOD_RES         1170
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000244|PubMed:18669648"
FT   MOD_RES         1181
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:18669648"
FT   MOD_RES         1265
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:20068231,
FT                   ECO:0000244|PubMed:23186163"
FT   MOD_RES         1382
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:18669648"
FT   VAR_SEQ         1..389
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_025253"
FT   VAR_SEQ         390..409
FT                   /note="MSDSDLMGKTMTEDDDITTG -> MLHLPLPRSGRTVNFPRS (in
FT                   isoform 5)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_025254"
FT   VAR_SEQ         999..1055
FT                   /note="Missing (in isoform 4 and isoform 7)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_025255"
FT   VAR_SEQ         1074..1081
FT                   /note="Missing (in isoform 2, isoform 6 and isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:10574461,
FT                   ECO:0000303|PubMed:14702039"
FT                   /id="VSP_025256"
FT   VAR_SEQ         1173..1198
FT                   /note="ELRIKRQNSSDSISSLNSITSHSSIG -> GRTSSHRLRGNREQESKSITDF
FT                   YLGP (in isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:10574461"
FT                   /id="VSP_025257"
FT   VAR_SEQ         1199..1877
FT                   /note="Missing (in isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:10574461"
FT                   /id="VSP_025258"
FT   VAR_SEQ         1214..1216
FT                   /note="Missing (in isoform 3, isoform 4, isoform 5 and
FT                   isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_025259"
FT   VARIANT         937
FT                   /note="Q -> H (in dbSNP:rs16849342)"
FT                   /id="VAR_032245"
FT   VARIANT         1273
FT                   /note="S -> L (in dbSNP:rs2820289)"
FT                   /evidence="ECO:0000269|PubMed:12079279"
FT                   /id="VAR_032246"
FT   VARIANT         1290
FT                   /note="H -> D (in dbSNP:rs2292822)"
FT                   /id="VAR_032247"
FT   VARIANT         1527
FT                   /note="V -> I (in dbSNP:rs16849379)"
FT                   /id="VAR_032248"
FT   CONFLICT        267..269
FT                   /note="DLR -> FLW (in Ref. 5; BAA86465)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        417
FT                   /note="S -> R (in Ref. 2; AAL05591)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        508
FT                   /note="C -> R (in Ref. 6; BAB14142)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        964
FT                   /note="S -> P (in Ref. 6; BAB14142)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1092
FT                   /note="S -> L (in Ref. 6; BAB14142)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1109
FT                   /note="N -> S (in Ref. 6; BAB14142)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1793
FT                   /note="E -> K (in Ref. 6; BAB14865)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1877 AA;  202472 MW;  B18C9AC9DC8D9CF2 CRC64;
     MLGSSVKSVQ PEVELSSGGG DEGADEPRGA GRKAAAADGR GMLPKRAKAP GGGGGMAKAS
     AAELKVFKSG SVDSRVPGGP PASNLRKQKS LTNLSFLTDS EKKLQLYEPE WSDDMAKAPK
     GLGKVGSKGR EAPLMSKTLS KSEHSLFQAK GSPAGGAKTP LAPLAPNLGK PSRIPRGPYA
     EVKPLSKAPE AAVSEDGKSD DELLSSKAKA QKSSGPVPSA KGQEERAFLK VDPELVVTVL
     GDLEQLLFSQ MLDPESQRKR TVQNVLDLRQ NLEETMSSLR GSQVTHSSLE MTCYDSDDAN
     PRSVSSLSNR SSPLSWRYGQ SSPRLQAGDA PSVGGSCRSE GTPAWYMHGE RAHYSHTMPM
     RSPSKLSHIS RLELVESLDS DEVDLKSGYM SDSDLMGKTM TEDDDITTGW DESSSISSGL
     SDASDNLSSE EFNASSSLNS LPSTPTASRR NSTIVLRTDS EKRSLAESGL SWFSESEEKA
     PKKLEYDSGS LKMEPGTSKW RRERPESCDD SSKGGELKKP ISLGHPGSLK KGKTPPVAVT
     SPITHTAQSA LKVAGKPEGK ATDKGKLAVK NTGLQRSSSD AGRDRLSDAK KPPSGIARPS
     TSGSFGYKKP PPATGTATVM QTGGSATLSK IQKSSGIPVK PVNGRKTSLD VSNSAEPGFL
     APGARSNIQY RSLPRPAKSS SMSVTGGRGG PRPVSSSIDP SLLSTKQGGL TPSRLKEPTK
     VASGRTTPAP VNQTDREKEK AKAKAVALDS DNISLKSIGS PESTPKNQAS HPTATKLAEL
     PPTPLRATAK SFVKPPSLAN LDKVNSNSLD LPSSSDTTHA SKVPDLHATS SASGGPLPSC
     FTPSPAPILN INSASFSQGL ELMSGFSVPK ETRMYPKLSG LHRSMESLQM PMSLPSAFPS
     STPVPTPPAP PAAPTEEETE ELTWSGSPRA GQLDSNQRDR NTLPKKGLRY QLQSQEETKE
     RRHSHTIGGL PESDDQSELP SPPALPMSLS AKGQLTNIVS PTAATTPRIT RSNSIPTHEA
     AFELYSGSQM GSTLSLAERP KGMIRSGSFR DPTDDVHGSV LSLASSASST YSSAEERMQS
     EQIRKLRREL ESSQEKVATL TSQLSANANL VAAFEQSLVN MTSRLRHLAE TAEEKDTELL
     DLRETIDFLK KKNSEAQAVI QGALNASETT PKELRIKRQN SSDSISSLNS ITSHSSIGSS
     KDADAKKKKK KSWVYELRSS FNKAFSIKKG PKSASSYSDI EEIATPDSSA PSSPKLQHGS
     TETASPSIKS STSSSVGTDV TEGPAHPAPH TRLFHANEEE EPEKKEVSEL RSELWEKEMK
     LTDIRLEALN SAHQLDQLRE TMHNMQLEVD LLKAENDRLK VAPGPSSGST PGQVPGSSAL
     SSPRRSLGLA LTHSFGPSLA DTDLSPMDGI STCGPKEEVT LRVVVRMPPQ HIIKGDLKQQ
     EFFLGCSKVS GKVDWKMLDE AVFQVFKDYI SKMDPASTLG LSTESIHGYS ISHVKRVLDA
     EPPEMPPCRR GVNNISVSLK GLKEKCVDSL VFETLIPKPM MQHYISLLLK HRRLVLSGPS
     GTGKTYLTNR LAEYLVERSG REVTEGIVST FNMHQQSCKD LQLYLSNLAN QIDRETGIGD
     VPLVILLDDL SEAGSISELV NGALTCKYHK CPYIIGTTNQ PVKMTPNHGL HLSFRMLTFS
     NNVEPANGFL VRYLRRKLVE SDSDINANKE ELLRVLDWVP KLWYHLHTFL EKHSTSDFLI
     GPCFFLSCPI GIEDFRTWFI DLWNNSIIPY LQEGAKDGIK VHGQKAAWED PVEWVRDTLP
     WPSAQQDQSK LYHLPPPTVG PHSIASPPED RTVKDSTPSS LDSDPLMAML LKLQEAANYI
     ESPDRETILD PNLQATL
//
DBGET integrated database retrieval system