ID O5AU1_HUMAN Reviewed; 362 AA.
AC Q8NGC0; B2RP78; Q6IEU2; Q96R10;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 24-JAN-2024, entry version 163.
DE RecName: Full=Olfactory receptor 5AU1;
DE AltName: Full=Olfactory receptor OR14-38;
GN Name=OR5AU1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS PHE-117 AND VAL-299.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 119-335.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC06114.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5AU1";
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DR EMBL; AB065898; BAC06114.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL157687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137304; AAI37305.1; -; mRNA.
DR EMBL; BC137305; AAI37306.1; -; mRNA.
DR EMBL; AF399635; AAK95120.1; -; Genomic_DNA.
DR EMBL; BK004520; DAA04918.1; -; Genomic_DNA.
DR RefSeq; NP_001004731.1; NM_001004731.1.
DR AlphaFoldDB; Q8NGC0; -.
DR SMR; Q8NGC0; -.
DR STRING; 9606.ENSP00000493431; -.
DR GlyCosmos; Q8NGC0; 1 site, No reported glycans.
DR GlyGen; Q8NGC0; 1 site.
DR iPTMnet; Q8NGC0; -.
DR PhosphoSitePlus; Q8NGC0; -.
DR BioMuta; OR5AU1; -.
DR DMDM; 212276450; -.
DR PaxDb; 9606-ENSP00000302057; -.
DR ProteomicsDB; 73470; -.
DR Antibodypedia; 56287; 66 antibodies from 16 providers.
DR DNASU; 390445; -.
DR Ensembl; ENST00000641822.1; ENSP00000493431.1; ENSG00000169327.5.
DR GeneID; 390445; -.
DR KEGG; hsa:390445; -.
DR UCSC; uc010tlp.3; human.
DR AGR; HGNC:15362; -.
DR CTD; 390445; -.
DR GeneCards; OR5AU1; -.
DR HGNC; HGNC:15362; OR5AU1.
DR HPA; ENSG00000169327; Not detected.
DR neXtProt; NX_Q8NGC0; -.
DR OpenTargets; ENSG00000169327; -.
DR PharmGKB; PA32474; -.
DR VEuPathDB; HostDB:ENSG00000169327; -.
DR eggNOG; ENOG502T9SD; Eukaryota.
DR GeneTree; ENSGT01100000263494; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGC0; -.
DR OrthoDB; 5317957at2759; -.
DR PhylomeDB; Q8NGC0; -.
DR TreeFam; TF352750; -.
DR PathwayCommons; Q8NGC0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390445; 10 hits in 754 CRISPR screens.
DR GeneWiki; OR5AU1; -.
DR GenomeRNAi; 390445; -.
DR Pharos; Q8NGC0; Tdark.
DR PRO; PR:Q8NGC0; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NGC0; Protein.
DR Bgee; ENSG00000169327; Expressed in blood and 1 other cell type or tissue.
DR ExpressionAtlas; Q8NGC0; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR CDD; cd15408; 7tmA_OR5AK3-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR48018:SF105; OLFACTORY RECEPTOR; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..362
FT /note="Olfactory receptor 5AU1"
FT /id="PRO_0000150582"
FT TOPO_DOM 1..79
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..116
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..139
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..150
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..194
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..247
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..290
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 312..322
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..362
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 148..230
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 80
FT /note="V -> M (in dbSNP:rs17102042)"
FT /id="VAR_047234"
FT VARIANT 117
FT /note="L -> F (in dbSNP:rs4982419)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_047235"
FT VARIANT 194
FT /note="S -> L (in dbSNP:rs59120409)"
FT /id="VAR_062039"
FT VARIANT 274
FT /note="N -> K (in dbSNP:rs57985939)"
FT /id="VAR_062040"
FT VARIANT 299
FT /note="I -> V (in dbSNP:rs7145814)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_047236"
SQ SEQUENCE 362 AA; 40658 MW; 3E6E7BF1DA20864E CRC64;
MTEFHLQSQM PSIRLIFRRL SLGRIKPSQS PRCSTSFMVV PSFSIAEHWR RMKGANLSQG
MEFELLGLTT DPQLQRLLFV VFLGMYTATL LGNLVMFLLI HVSATLHTPM YSLLKSLSFL
DFCYSSTVVP QTLVNFLAKR KVISYFGCMT QMFFYAGFAT SECYLIAAMA YDRYAAICNP
LLYSTIMSPE VCASLIVGSY SAGFLNSLIH TGCIFSLKFC GAHVVTHFFC DGPPILSLSC
VDTSLCEILL FIFAGFNLLS CTLTILISYF LILNTILKMS SAQGRFKAFS TCASHLTAIC
LFFGTTLFMY LRPRSSYSLT QDRTVAVIYT VVIPVLNPLM YSLRNKDVKK ALIKVWGRKT
ME
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