ID O51D1_HUMAN Reviewed; 324 AA.
AC Q8NGF3; B9EIK4;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 24-JAN-2024, entry version 151.
DE RecName: Full=Olfactory receptor 51D1;
DE AltName: Full=Olfactory receptor OR11-14;
GN Name=OR51D1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-89.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51D1";
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DR EMBL; AB065855; BAC06073.1; -; Genomic_DNA.
DR EMBL; BC140717; AAI40718.1; -; mRNA.
DR EMBL; BK004370; DAA04768.1; -; Genomic_DNA.
DR CCDS; CCDS31357.1; -.
DR RefSeq; NP_001004751.1; NM_001004751.2.
DR AlphaFoldDB; Q8NGF3; -.
DR SMR; Q8NGF3; -.
DR STRING; 9606.ENSP00000492986; -.
DR PhosphoSitePlus; Q8NGF3; -.
DR BioMuta; OR51D1; -.
DR DMDM; 71153025; -.
DR MassIVE; Q8NGF3; -.
DR PaxDb; 9606-ENSP00000350222; -.
DR PeptideAtlas; Q8NGF3; -.
DR Antibodypedia; 57488; 52 antibodies from 17 providers.
DR DNASU; 390038; -.
DR Ensembl; ENST00000357605.2; ENSP00000350222.2; ENSG00000197428.3.
DR Ensembl; ENST00000641817.1; ENSP00000492986.1; ENSG00000197428.3.
DR GeneID; 390038; -.
DR KEGG; hsa:390038; -.
DR MANE-Select; ENST00000641817.1; ENSP00000492986.1; NM_001004751.3; NP_001004751.1.
DR UCSC; uc010qyk.2; human.
DR AGR; HGNC:15193; -.
DR CTD; 390038; -.
DR DisGeNET; 390038; -.
DR GeneCards; OR51D1; -.
DR HGNC; HGNC:15193; OR51D1.
DR HPA; ENSG00000197428; Not detected.
DR neXtProt; NX_Q8NGF3; -.
DR PharmGKB; PA32370; -.
DR VEuPathDB; HostDB:ENSG00000197428; -.
DR eggNOG; ENOG502R2IG; Eukaryota.
DR GeneTree; ENSGT01100000263490; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGF3; -.
DR OMA; LGPNIHF; -.
DR OrthoDB; 4578140at2759; -.
DR PhylomeDB; Q8NGF3; -.
DR TreeFam; TF342735; -.
DR PathwayCommons; Q8NGF3; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390038; 13 hits in 750 CRISPR screens.
DR GeneWiki; OR51D1; -.
DR GenomeRNAi; 390038; -.
DR Pharos; Q8NGF3; Tdark.
DR PRO; PR:Q8NGF3; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGF3; Protein.
DR Bgee; ENSG00000197428; Expressed in stromal cell of endometrium and 1 other cell type or tissue.
DR ExpressionAtlas; Q8NGF3; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR CDD; cd15222; 7tmA_OR51-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26450:SF166; OLFACTORY RECEPTOR 51D1; 1.
DR PANTHER; PTHR26450; OLFACTORY RECEPTOR 56B1-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..324
FT /note="Olfactory receptor 51D1"
FT /id="PRO_0000150749"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..209
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..285
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 110..202
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 89
FT /note="I -> V (in dbSNP:rs905871)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_053323"
SQ SEQUENCE 324 AA; 35839 MW; 52401F88565E3BD1 CRC64;
MQKPQLLVPI IATSNGNLVH AAYFLLVGIP GLGPTIHFWL AFPLCFMYAL ATLGNLTIVL
IIRVERRLHE PMYLFLAMLS TIDLVLSSIT MPKMASLFLM GIQEIEFNIC LAQMFLIHAL
SAVESAVLLA MAFDRFVAIC HPLRHASVLT GCTVAKIGLS ALTRGFVFFF PLPFILKWLS
YCQTHTVTHS FCLHQDIMKL SCTDTRVNVV YGLFIILSVM GVDSLFIGFS YILILWAVLE
LSSRRAALKA FNTCISHLCA VLVFYVPLIG LSVVHRLGGP TSLLHVVMAN TYLLLPPVVN
PLVYGAKTKE ICSRVLCMFS QGGK
//
