ID OR6K6_HUMAN Reviewed; 343 AA.
AC Q8NGW6; B9EIM8; Q5VUU9; Q6IFR4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 24-JAN-2024, entry version 163.
DE RecName: Full=Olfactory receptor 6K6;
DE AltName: Full=Olfactory receptor OR1-21;
GN Name=OR6K6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-25 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05876.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6K6";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065650; BAC05876.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL513205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC140743; AAI40744.1; -; mRNA.
DR EMBL; BK004198; DAA04596.1; -; Genomic_DNA.
DR RefSeq; NP_001005184.1; NM_001005184.1.
DR AlphaFoldDB; Q8NGW6; -.
DR SMR; Q8NGW6; -.
DR STRING; 9606.ENSP00000357126; -.
DR GlyCosmos; Q8NGW6; 1 site, No reported glycans.
DR GlyGen; Q8NGW6; 1 site.
DR iPTMnet; Q8NGW6; -.
DR PhosphoSitePlus; Q8NGW6; -.
DR BioMuta; OR6K6; -.
DR DMDM; 223590118; -.
DR PaxDb; 9606-ENSP00000357126; -.
DR Antibodypedia; 68463; 79 antibodies from 18 providers.
DR DNASU; 128371; -.
DR GeneID; 128371; -.
DR KEGG; hsa:128371; -.
DR UCSC; uc001fsw.2; human.
DR AGR; HGNC:15033; -.
DR CTD; 128371; -.
DR GeneCards; OR6K6; -.
DR HGNC; HGNC:15033; OR6K6.
DR neXtProt; NX_Q8NGW6; -.
DR PharmGKB; PA32593; -.
DR VEuPathDB; HostDB:ENSG00000180433; -.
DR eggNOG; ENOG502T1JP; Eukaryota.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q8NGW6; -.
DR OMA; FIVIQVD; -.
DR OrthoDB; 4639121at2759; -.
DR PhylomeDB; Q8NGW6; -.
DR TreeFam; TF337562; -.
DR PathwayCommons; Q8NGW6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 128371; 8 hits in 745 CRISPR screens.
DR GeneWiki; OR6K6; -.
DR GenomeRNAi; 128371; -.
DR Pharos; Q8NGW6; Tdark.
DR PRO; PR:Q8NGW6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGW6; Protein.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR CDD; cd15914; 7tmA_OR6N-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR24242; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24242:SF379; OLFACTORY RECEPTOR; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..343
FT /note="Olfactory receptor 6K6"
FT /id="PRO_0000150631"
FT TOPO_DOM 1..53
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..127
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..224
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..244
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..264
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..298
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 320..343
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 125..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 39
FT /note="E -> D (in dbSNP:rs16840974)"
FT /id="VAR_057551"
FT VARIANT 49
FT /note="H -> Y (in dbSNP:rs16840976)"
FT /id="VAR_057552"
FT VARIANT 80
FT /note="G -> D (in dbSNP:rs16840980)"
FT /id="VAR_057553"
FT VARIANT 134
FT /note="S -> L (in dbSNP:rs16840991)"
FT /id="VAR_057554"
FT VARIANT 159
FT /note="R -> C (in dbSNP:rs16841001)"
FT /id="VAR_057555"
FT VARIANT 197
FT /note="C -> R (in dbSNP:rs16841009)"
FT /id="VAR_057556"
FT VARIANT 211
FT /note="P -> L (in dbSNP:rs16841017)"
FT /id="VAR_057557"
FT VARIANT 247
FT /note="R -> Q (in dbSNP:rs16841038)"
FT /id="VAR_057558"
FT VARIANT 261
FT /note="H -> R (in dbSNP:rs16841042)"
FT /id="VAR_057559"
FT VARIANT 320
FT /note="K -> R (in dbSNP:rs16841045)"
FT /id="VAR_057560"
SQ SEQUENCE 343 AA; 38362 MW; 0786F45F4BA67CBB CRC64;
MKQYSVGNQH SNYRSLLFPF LCSQMTQLTA SGNQTMVTEF LFSMFPHAHR GGLLFFIPLL
LIYGFILTGN LIMFIVIQVG MALHTPLYFF ISVLSFLEIC YTTTTIPKML SCLISEQKSI
SVAGCLLQMY FFHSLGITES CVLTAMAIDR YIAICNPLRY PTIMIPKLCI QLTVGSCFCG
FLLVLPEIAW ISTLPFCGSN QIHQIFCDFT PVLSLACTDT FLVVIVDAIH AAEIVASFLV
IALSYIRIII VILGMHSAEG HHKAFSTCAA HLAVFLLFFG SVAVMYLRFS ATYSVFWDTA
IAVTFVILAP FFNPIIYSLK NKDMKEAIGR LFHYQKRAGW AGK
//
