ID OR1S1_HUMAN Reviewed; 325 AA.
AC Q8NH92; Q6IFG3;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 24-JAN-2024, entry version 153.
DE RecName: Full=Olfactory receptor 1S1;
DE AltName: Full=Olfactory receptor OR11-232;
GN Name=OR1S1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-14 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05745.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1S1";
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DR EMBL; AB065493; BAC05745.1; ALT_INIT; Genomic_DNA.
DR EMBL; CH471076; EAW73800.1; -; Genomic_DNA.
DR EMBL; BK004299; DAA04697.1; -; Genomic_DNA.
DR RefSeq; NP_001004458.1; NM_001004458.1.
DR AlphaFoldDB; Q8NH92; -.
DR SMR; Q8NH92; -.
DR STRING; 9606.ENSP00000485156; -.
DR GlyCosmos; Q8NH92; 1 site, No reported glycans.
DR GlyGen; Q8NH92; 1 site.
DR iPTMnet; Q8NH92; -.
DR PhosphoSitePlus; Q8NH92; -.
DR BioMuta; OR1S1; -.
DR DMDM; 218511728; -.
DR MassIVE; Q8NH92; -.
DR PaxDb; 9606-ENSP00000311688; -.
DR PeptideAtlas; Q8NH92; -.
DR Antibodypedia; 78312; 37 antibodies from 14 providers.
DR DNASU; 219959; -.
DR GeneID; 219959; -.
DR KEGG; hsa:219959; -.
DR UCSC; uc010rkc.2; human.
DR AGR; HGNC:8227; -.
DR CTD; 219959; -.
DR GeneCards; OR1S1; -.
DR HGNC; HGNC:8227; OR1S1.
DR neXtProt; NX_Q8NH92; -.
DR PharmGKB; PA32098; -.
DR VEuPathDB; HostDB:ENSG00000280204; -.
DR eggNOG; ENOG502RQAM; Eukaryota.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NH92; -.
DR OrthoDB; 5401587at2759; -.
DR PhylomeDB; Q8NH92; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q8NH92; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219959; 11 hits in 663 CRISPR screens.
DR GeneWiki; OR1S1; -.
DR GenomeRNAi; 219959; -.
DR Pharos; Q8NH92; Tdark.
DR PRO; PR:Q8NH92; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH92; Protein.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd15918; 7tmA_OR1_7-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR48001:SF115; OLFACTORY RECEPTOR 1S1-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..325
FT /note="Olfactory receptor 1S1"
FT /id="PRO_0000150451"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..92
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..171
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..208
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..285
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..305
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..325
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 110..202
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 5
FT /note="S -> G (in dbSNP:rs1966836)"
FT /id="VAR_048039"
FT VARIANT 123
FT /note="I -> T (in dbSNP:rs1966835)"
FT /id="VAR_048040"
FT VARIANT 135
FT /note="H -> R (in dbSNP:rs1966834)"
FT /id="VAR_048041"
FT VARIANT 183
FT /note="N -> D (in dbSNP:rs1993088)"
FT /id="VAR_048042"
FT VARIANT 206
FT /note="L -> M (in dbSNP:rs2867400)"
FT /id="VAR_048043"
FT VARIANT 227
FT /note="S -> I (in dbSNP:rs2903566)"
FT /id="VAR_048044"
SQ SEQUENCE 325 AA; 36707 MW; CDA11EA9E0CD4588 CRC64;
MKTFSSFLQI GRNMHQGNQT TITEFILLGF FKQDEHQNLL FVLFLGMYLV TVIGNGLIIV
AISLDTYLHT PMYLFLANLS FADISSISNS VPKMLVNIQT KSQSISYESC ITQMYFSIVF
VVIDNLLLGT MAYDHFVAIC HPLNYTILMR PRFGILLTVI SWFLSNIIAL THTLLLIQLL
FCNHNTLPHF FCDLAPLLKL SCSDTLINEL VLFIVGLSVI IFPFTLSFFS YVCIIRAVLR
VSSTQGKWKA FSTCGSHLTV VLLFYGTIVG VYFFPSSTHP EDTDKIGAVL FTVVTPMINP
FIYSLRNKDM KGALRKLINR KISSL
//
