ID Q8QMW7_CWPXB Unreviewed; 1286 AA.
AC Q8QMW7;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=DNA-directed RNA polymerase 147 kDa polypeptide {ECO:0000256|ARBA:ARBA00021673};
DE EC=2.7.7.6 {ECO:0000256|ARBA:ARBA00012418};
GN Name=CPXV109 CDS {ECO:0000313|EMBL:AAM13552.1};
OS Cowpox virus (strain Brighton Red) (CPV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Cowpox virus.
OX NCBI_TaxID=265872 {ECO:0000313|EMBL:AAM13552.1, ECO:0000313|Proteomes:UP000152733};
OH NCBI_TaxID=9913; Bos taurus (Bovine).
OH NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH NCBI_TaxID=10090; Mus musculus (Mouse).
OH NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN [1] {ECO:0000313|EMBL:AAM13552.1, ECO:0000313|Proteomes:UP000152733}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brighton Red {ECO:0000313|EMBL:AAM13552.1};
RX PubMed=6961398; DOI=10.1073/pnas.79.23.7112;
RA Pickup D.J., Bastia D., Stone H.O., Joklik W.K.;
RT "Sequence of terminal regions of cowpox virus DNA: arrangement of repeated
RT and unique sequence elements.";
RL Proc. Natl. Acad. Sci. U.S.A. 79:7112-7116(1982).
RN [2] {ECO:0000313|EMBL:AAM13552.1, ECO:0000313|Proteomes:UP000152733}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brighton Red {ECO:0000313|EMBL:AAM13552.1};
RX PubMed=2309453; DOI=10.1016/0042-6822(90)90187-V;
RA Parsons B.L., Pickup D.J.;
RT "Transcription of orthopoxvirus telomeres at late times during infection.";
RL Virology 175:69-80(1990).
RN [3] {ECO:0000313|EMBL:AAM13552.1, ECO:0000313|Proteomes:UP000152733}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brighton Red {ECO:0000313|EMBL:AAM13552.1};
RX PubMed=2014645; DOI=10.1016/0042-6822(91)90905-Q;
RA Hu F.Q., Pickup D.J.;
RT "Transcription of the terminal loop region of vaccinia virus DNA is
RT initiated from the telomere sequences directing DNA resolution.";
RL Virology 181:716-720(1991).
RN [4] {ECO:0000313|EMBL:AAM13552.1, ECO:0000313|Proteomes:UP000152733}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brighton Red {ECO:0000313|EMBL:AAM13552.1};
RX PubMed=8091665; DOI=10.1006/viro.1994.1539;
RA Hu F.Q., Smith C.A., Pickup D.J.;
RT "Cowpox virus contains two copies of an early gene encoding a soluble
RT secreted form of the type II TNF receptor.";
RL Virology 204:343-356(1994).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550};
CC -!- SIMILARITY: Belongs to the poxviridae DNA-directed RNA polymerase 147
CC kDa subunit family. {ECO:0000256|ARBA:ARBA00006884}.
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DR EMBL; AF482758; AAM13552.1; -; Genomic_DNA.
DR RefSeq; NP_619894.1; NC_003663.2.
DR GeneID; 1485986; -.
DR KEGG; vg:1485986; -.
DR Proteomes; UP000152733; Segment.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF37; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 188..469
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
SQ SEQUENCE 1286 AA; 146657 MW; 57F93E9983E4BF93 CRC64;
MAVISKVTYS LYDQKEINAT DIIISHVKND DDIGTVKDGR LGAMDGALCK TCGKTELECF
GHWGKVSIYK THIVKPEFIS EIIRLLNHIC IHCGLLRSRE PYSDDINLKE LSGHALRRLK
DKILSKKKSC WNSECMQPYQ KITFSKKKVC FVNKLDDINV PNSLIYQKLI SIHEKFWPLL
EIHQYPANLF YTDYFPIPPL IIRPAISFWI DSIPKETNEL TYLLGMIVKN CNLNADEQVI
QKAVIEYDDI KIISNNTTSI NLSYITSGKN NMIRSYIVAR RKDQTARSVI GPSTAITINE
VGMPAYIRNT LTEKIFVNAF TVDKVKQLLA SNQVKFYFNK RLNQLTRIRQ GKFIKNKIHL
LPGDWVEVAV QEYTSIIFGR QPSLHRYNVI ASSIRATEGD TIKISPGIAN SQNADFDGDE
EWMILEQNPK AVVEQSILMY PTTLLKHDIH GAPVYGSIQD EIVAAYSLFR IQDLCLDEVL
NILGKYGREF DPKGKCKFSG KDIYTYLIGE KINYPGLLKD GEIIANDVDS NFVVAMRHLS
LAGLLSDHKS NVEGINFIIK SSYVFKRYLA IYGFGVTFKD LRPNSTFTNK LEAINVEKIE
LIKDAYAKYL KDVRDGKIVP LSKALEADYV ESMLSNLTNL NIREIEEHMR QTLIDDPDNN
LLKMAKAGYK VNPTELMYIL GTYGQQRIDG EPAETRVLGR VLPYYLPDSK DPEGRGYILN
SLTKGLTGSQ YYFSMLVARS QSTDIVCETS RTGTLARKII KKMEDMVVDG YGQVVIGNTL
IKYAANYTKI LGSVCKPVDL IYPDESMTWY LEISALWNKI KQGFVYSQKQ KLAKKTLAPF
NFLVFVKPTT EDNAIKVKDL YDMIHNVIDD VREKYFFTVS NIDFMEYIFL THLNPSRIRI
TKETAITIFE KFYEKLNYTL GGGTPIGIIS AQVLSEKFTQ QALSSFHTTE KSGAVKQKLG
FNEFNNLTNL SKNKTEIITL VSDDISKLQS VKINFEFVCL GELNPDITLR KETGRYVVDI
IVNRLYIKRA EITELVVEYM IERFVSFSVI VKEWGMETFI EDDDNIRFTV YLNFVEPEEL
NLSKFMMVLP GAANKGKISK FKIPISDYTG YDDFNQTKKL NKMTVELMNL KELGSFDLEN
VNVYPGVWNT YDIFGIEAAR GYLCEAMLNT YGEGFDYLYQ PCDLLASLLC ASYEPESVNK
FKFGAASTLK RATFGDNKAL LNAALHKKSE PINDNSSCHF FSKVPNIGTG YYKYFIDLGL
LMRMERKLSD KISSQKIKEM EETEDF
//
