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Database: UniProt
Entry: Q8R4G1
LinkDB: Q8R4G1
Original site: Q8R4G1 
ID   MRGX1_RAT               Reviewed;         323 AA.
AC   Q8R4G1; Q7TN42;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 3.
DT   27-MAR-2024, entry version 118.
DE   RecName: Full=Mas-related G-protein coupled receptor member X1;
DE   AltName: Full=Sensory neuron-specific G-protein coupled receptor 1;
GN   Name=Mrgprx1; Synonyms=Mrgc, Mrgprc, Mrgprc11, Snsr, Snsr1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=11850634; DOI=10.1038/nn815;
RA   Lembo P.M.C., Grazzini E., Groblewski T., O'Donnell D., Roy M.-O.,
RA   Zhang J., Hoffert C., Cao J., Schmidt R., Pelletier M., Labarre M.,
RA   Gosselin M., Fortin Y., Banville D., Shen S., Stroem P., Payza K., Dray A.,
RA   Walker P., Ahmad S.;
RT   "Proenkephalin A gene products activate a new family of sensory neuron-
RT   specific GPCRs.";
RL   Nat. Neurosci. 5:201-209(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=12909716; DOI=10.1073/pnas.1732949100;
RA   Zylka M.J., Dong X., Southwell A.L., Anderson D.J.;
RT   "Atypical expansion in mice of the sensory neuron-specific Mrg G protein-
RT   coupled receptor family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
CC   -!- FUNCTION: Orphan receptor activated by neuropeptides terminating in
CC       Arg-Phe or Arg-Phe-amide. Mediates its action by association with G
CC       proteins that activate a phosphatidylinositol-calcium second messenger
CC       system. Its effect is mediated by G(q) and G(11) proteins. May regulate
CC       the function of nociceptive neurons by modulation of pain perception
CC       (By similarity). {ECO:0000250|UniProtKB:Q96LB2}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Uniquely localized in a subset of small dorsal root
CC       and trigeminal sensory neurons. Associated preferentially with IB4
CC       class of small-diameter somatosensory afferents (also known as
CC       nociceptors). {ECO:0000269|PubMed:11850634,
CC       ECO:0000269|PubMed:12909716}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL86877.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF474986; AAL86877.2; ALT_INIT; Genomic_DNA.
DR   EMBL; AF518245; AAQ08317.1; -; Genomic_DNA.
DR   RefSeq; NP_001002286.1; NM_001002286.1.
DR   RefSeq; NP_750845.2; NM_172158.2.
DR   RefSeq; XP_017444332.1; XM_017588843.1.
DR   AlphaFoldDB; Q8R4G1; -.
DR   SMR; Q8R4G1; -.
DR   STRING; 10116.ENSRNOP00000019061; -.
DR   BindingDB; Q8R4G1; -.
DR   ChEMBL; CHEMBL3341575; -.
DR   GlyCosmos; Q8R4G1; 1 site, No reported glycans.
DR   GlyGen; Q8R4G1; 1 site.
DR   PaxDb; 10116-ENSRNOP00000019061; -.
DR   Ensembl; ENSRNOT00065014599; ENSRNOP00065010928; ENSRNOG00065009144.
DR   GeneID; 282547; -.
DR   KEGG; rno:282547; -.
DR   UCSC; RGD:632284; rat.
DR   AGR; RGD:632284; -.
DR   CTD; 259249; -.
DR   RGD; 632284; Mrgprx1.
DR   eggNOG; ENOG502RTWA; Eukaryota.
DR   InParanoid; Q8R4G1; -.
DR   OrthoDB; 4338913at2759; -.
DR   PhylomeDB; Q8R4G1; -.
DR   TreeFam; TF336336; -.
DR   PRO; PR:Q8R4G1; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0007635; P:chemosensory behavior; ISO:RGD.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISO:RGD.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR026234; MRGPCRFAMILY.
DR   PANTHER; PTHR11334; MAS-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR11334:SF67; MAS-RELATED G-PROTEIN COUPLED RECEPTOR MEMBER X1; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR02108; MRGPCRFAMILY.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..323
FT                   /note="Mas-related G-protein coupled receptor member X1"
FT                   /id="PRO_0000070109"
FT   TOPO_DOM        1..30
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        52..59
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..143
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..180
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        202..226
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        248..258
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        280..323
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        16
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        105..107
FT                   /note="AAI -> VAF (in Ref. 2; AAQ08317)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   323 AA;  37074 MW;  40DE6E2C6420EE4B CRC64;
     MDPTISSLST ESTTLNKTGH PSCRPILTLS FLVPIITLLG LAGNTIVLWL LGFRMRRKAI
     SVYVLNLSLA DSFFLCCHFI DSLMRIMNFY GIYAHKLSKE ILGNAAIIPY ISGLSILSAI
     STERCLSVLW PIWYHCHRPR NMSAIICVLI WVLSFLMGIL DWFFSGFLGE THHHLWKNVD
     FIVTAFLIFL FMLLFGSSLA LLVRILCGSR RKPLSRLYVT ISLTVMVYLI CGLPLGLYLF
     LLYWFGIHLH YPFCHIYQVT VLLSCVNSSA NPIIYFLVGS FRHRKKHRSL KMVLKRALEE
     TPEEDEYTDS HVQKPTEISE RRC
//
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