ID Q8RAY9_CALS4 Unreviewed; 803 AA.
AC Q8RAY9;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=CheA {ECO:0000313|EMBL:AAM24293.1};
GN OrderedLocusNames=TTE1039 {ECO:0000313|EMBL:AAM24293.1};
OS Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM
OS 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis).
OC Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Caldanaerobacter.
OX NCBI_TaxID=273068 {ECO:0000313|EMBL:AAM24293.1, ECO:0000313|Proteomes:UP000000555};
RN [1] {ECO:0000313|EMBL:AAM24293.1, ECO:0000313|Proteomes:UP000000555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15242 / JCM 11007 / NBRC 100824 / MB4
RC {ECO:0000313|Proteomes:UP000000555};
RX PubMed=11997336; DOI=10.1101/gr.219302;
RA Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y.,
RA Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R.,
RA Wang J., Yu J., Yang H.;
RT "A complete sequence of the T. tengcongensis genome.";
RL Genome Res. 12:689-700(2002).
CC -!- FUNCTION: Involved in the transmission of sensory signals from the
CC chemoreceptors to the flagellar motors. CheA is autophosphorylated; it
CC can transfer its phosphate group to either CheB or CheY.
CC {ECO:0000256|ARBA:ARBA00035100}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE008691; AAM24293.1; -; Genomic_DNA.
DR RefSeq; WP_011025407.1; NZ_JANUCV010000001.1.
DR AlphaFoldDB; Q8RAY9; -.
DR STRING; 273068.TTE1039; -.
DR KEGG; tte:TTE1039; -.
DR eggNOG; COG0643; Bacteria.
DR HOGENOM; CLU_000650_3_3_9; -.
DR Proteomes; UP000000555; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR CDD; cd16916; HATPase_CheA-like; 1.
DR Gene3D; 1.10.287.560; Histidine kinase CheA-like, homodimeric domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR004105; CheA-like_dim.
DR InterPro; IPR037006; CheA-like_homodim_sf.
DR InterPro; IPR036061; CheW-like_dom_sf.
DR InterPro; IPR002545; CheW-lke_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43395:SF10; CHEMOTAXIS PROTEIN CHEA; 1.
DR PANTHER; PTHR43395; SENSOR HISTIDINE KINASE CHEA; 1.
DR Pfam; PF01584; CheW; 1.
DR Pfam; PF02895; H-kinase_dim; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00260; CheW; 1.
DR SMART; SM01231; H-kinase_dim; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF50341; CheW-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50851; CHEW; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:AAM24293.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000555};
KW Transferase {ECO:0000313|EMBL:AAM24293.1};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 469..671
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 673..803
FT /note="CheW-like"
FT /evidence="ECO:0000259|PROSITE:PS50851"
SQ SEQUENCE 803 AA; 91073 MW; 3521EF949441BD8F CRC64;
MKNESNGFIK NAKKLLDNIG FFVLGLEDAY EKDKAAEEIL SRLSELLQLC KSYDFNKLSS
FIESLIKLIK EIAQKEKFLD TEISDFLLDS FERIISLVEN AEKEGLETLK APELKEFEGR
ISEFLDEMDK MPQASVIHTD DMLRTISKDK KIFLNELIQK SENVYEILLQ VVGTKAVEID
VTEFFDKLKE IGEVTHIDAD TRKLPLLEEL DPSIPYISLT FVLISDKNAQ EIEDTLYKVI
GTDTDVKVLV SPVFPDAIEK FTTSKGDSLS AMSAGEDKVQ EVMDMIISQQ EEFYKIAETP
EDRRWRGNMV INVLQRIAEY MGWVTKSGNL VKMIKTNKIK LPERFVNLVN LIINNDKKLQ
ENESKDRGVY AARTENEEIE RREIKQGEEK ILQEYNESIS RDMTNNKGFS EIETTKTLKV
DQTKIDELMK LVGELVAVNN GLSFMIKKIE MEYGSTDVTK ELKDKQVLLK RIGNDLQDIV
MSLRLLPIKY IFDRFPRMIR EISRKLDKKV RLVTEGEETQ IDKNIVTALY DPMLHIIRNA
IDHGIEKPEE RLKKGKSEEG LLVLKAQKIG DKVIIEVRDD GRGIDTEVVK AKAVQKGFVS
AEKGATMDEH AVLELLFIPG FSTSDDVTEL SGRGVGMDVV RDTVRRLGGN VRLMSKAGVG
TSVYLELPVT MVTSRVLLFT LKERRYALPL ESVGELVKIK AEDIRKMKGK EVVVLRGEIM
PLLRLKEFMG LQNDAEEKFD TEYSLVVLNN GVAVMVDEFI GEQEIIIRPL PEELSSVYFL
GAAILGDGDI VLVLNPEKLG GGI
//
