ID Q8REW9_FUSNN Unreviewed; 229 AA.
AC Q8REW9;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Precorrin-6Y C5,15-methyltransferase (Decarboxylating) {ECO:0000313|EMBL:AAL95162.1};
DE EC=2.1.1.132 {ECO:0000313|EMBL:AAL95162.1};
GN OrderedLocusNames=FN0966 {ECO:0000313|EMBL:AAL95162.1};
OS Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae;
OC Fusobacterium.
OX NCBI_TaxID=190304 {ECO:0000313|EMBL:AAL95162.1, ECO:0000313|Proteomes:UP000002521};
RN [1] {ECO:0000313|EMBL:AAL95162.1, ECO:0000313|Proteomes:UP000002521}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 /
RC KCTC 2640 / LMG 13131 / VPI 4355 {ECO:0000313|Proteomes:UP000002521};
RX PubMed=11889109; DOI=10.1128/JB.184.7.2005-2018.2002;
RA Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N., Overbeek R.;
RT "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT strain ATCC 25586.";
RL J. Bacteriol. 184:2005-2018(2002).
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE009951; AAL95162.1; -; Genomic_DNA.
DR RefSeq; NP_603863.1; NC_003454.1.
DR RefSeq; WP_011016791.1; NZ_CP028101.1.
DR AlphaFoldDB; Q8REW9; -.
DR STRING; 190304.FN0966; -.
DR PaxDb; 190304-FN0966; -.
DR EnsemblBacteria; AAL95162; AAL95162; FN0966.
DR GeneID; 79783949; -.
DR KEGG; fnu:FN0966; -.
DR PATRIC; fig|190304.8.peg.1531; -.
DR eggNOG; COG2241; Bacteria.
DR HOGENOM; CLU_089162_2_0_0; -.
DR InParanoid; Q8REW9; -.
DR BioCyc; FNUC190304:G1FZS-1548-MONOMER; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000002521; Chromosome.
DR GO; GO:0046025; F:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11644; Precorrin-6Y-MT; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR012818; CbiE.
DR NCBIfam; TIGR02467; CbiE; 1.
DR PANTHER; PTHR43182; COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING); 1.
DR PANTHER; PTHR43182:SF1; COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 4: Predicted;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AAL95162.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002521};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AAL95162.1}.
FT DOMAIN 16..204
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 229 AA; 26300 MW; 99D3F2995C4CBB9D CRC64;
MITIKEWLVN VVQLNKINVV GLGPGNIKYL STAGIDCIKQ AEIIIGSTRQ LSDLKTIISE
KQEIYILGKL NELITYLKEN VERKITIIVS GDTGYYSLVP YLSKNLSKNI LNIIPNISSY
QYLFSKLGEN WQNFRLASVH GREFDYIKNI NDEDIEGLVL LTDDIQNPYE ITKKLYNNGI
RNLTVIVGEN LSYDNEKITI LEIEDYKKLN RKFDMNVLIL KKGENYGKK
//
