ID Q8RFA6_FUSNN Unreviewed; 340 AA.
AC Q8RFA6;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Low-specificity threonine aldolase {ECO:0000313|EMBL:AAL95006.1};
DE EC=4.1.2.5 {ECO:0000313|EMBL:AAL95006.1};
GN OrderedLocusNames=FN0810 {ECO:0000313|EMBL:AAL95006.1};
OS Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae;
OC Fusobacterium.
OX NCBI_TaxID=190304 {ECO:0000313|EMBL:AAL95006.1, ECO:0000313|Proteomes:UP000002521};
RN [1] {ECO:0000313|EMBL:AAL95006.1, ECO:0000313|Proteomes:UP000002521}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 /
RC KCTC 2640 / LMG 13131 / VPI 4355 {ECO:0000313|Proteomes:UP000002521};
RX PubMed=11889109; DOI=10.1128/JB.184.7.2005-2018.2002;
RA Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N., Overbeek R.;
RT "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT strain ATCC 25586.";
RL J. Bacteriol. 184:2005-2018(2002).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the threonine aldolase family.
CC {ECO:0000256|ARBA:ARBA00006966}.
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DR EMBL; AE009951; AAL95006.1; -; Genomic_DNA.
DR RefSeq; NP_603707.1; NC_003454.1.
DR RefSeq; WP_011016665.1; NZ_CP028101.1.
DR AlphaFoldDB; Q8RFA6; -.
DR STRING; 190304.FN0810; -.
DR PaxDb; 190304-FN0810; -.
DR EnsemblBacteria; AAL95006; AAL95006; FN0810.
DR GeneID; 79783799; -.
DR KEGG; fnu:FN0810; -.
DR PATRIC; fig|190304.8.peg.1372; -.
DR eggNOG; COG2008; Bacteria.
DR HOGENOM; CLU_049619_1_0_0; -.
DR InParanoid; Q8RFA6; -.
DR BioCyc; FNUC190304:G1FZS-1395-MONOMER; -.
DR Proteomes; UP000002521; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0008732; F:L-allo-threonine aldolase activity; IBA:GO_Central.
DR GO; GO:0006545; P:glycine biosynthetic process; IBA:GO_Central.
DR GO; GO:0006567; P:threonine catabolic process; IBA:GO_Central.
DR CDD; cd06502; TA_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR48097; L-THREONINE ALDOLASE-RELATED; 1.
DR PANTHER; PTHR48097:SF5; LOW SPECIFICITY L-THREONINE ALDOLASE; 1.
DR Pfam; PF01212; Beta_elim_lyase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:AAL95006.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002521}.
FT DOMAIN 11..291
FT /note="Aromatic amino acid beta-eliminating lyase/threonine
FT aldolase"
FT /evidence="ECO:0000259|Pfam:PF01212"
SQ SEQUENCE 340 AA; 38328 MW; 8B2BBDB1D45770F5 CRC64;
MINFKNDYSE GACSEVLEAL IKTNYEQTVG YGEDEYCEKA KNLIKENINY PNANIYFLVG
GTQANTTVIS HSLRPYEAVI ACKTGHISIH ETGAIEATGH KIIEVDGIDG KLTPDLILNE
LRKHEDHHMV KPKMVYISNT TEIGTVYTKK ELENISKVCK DNNLYLYLDG ARLASALTSE
KCDINLEDYP RYCDVFYIGG TKCGLLFGEA VVIINDEIKK EFNFSVKQKG GLFAKGRLLG
IQFATLFKDD LYYRIGVHSN KMALKIKNAF IEKGIKLATD SYTNQVFVDL SQEQIKKLEK
DVIFSVEFFG IGESQSSRFV TSWATKEEDI DKLVELIKSL
//
