ID Q8RWN4_ARATH Unreviewed; 642 AA.
AC Q8RWN4;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 24-JAN-2024, entry version 142.
DE SubName: Full=Cytosolic IMP-GMP specific 5-nucleotidase, putative {ECO:0000313|EMBL:AAM12975.1};
DE SubName: Full=HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase {ECO:0000313|EMBL:AEE35688.1};
GN OrderedLocusNames=At1g75210 {ECO:0000313|Araport:AT1G75210,
GN ECO:0000313|EMBL:AEE35688.1};
GN ORFNames=F22H5.7 {ECO:0000313|EMBL:AEE35688.1}, F22H5_7
GN {ECO:0000313|EMBL:AEE35688.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AAM12975.1};
RN [1] {ECO:0000313|EMBL:AEE35688.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2] {ECO:0000313|EMBL:AAM12975.1}
RP NUCLEOTIDE SEQUENCE.
RA Southwick A., Karlin-Neumann G., Nguyen M., Lam B., Miranda M., Palm C.J.,
RA Bowser L., Jones T., Banh J., Carninci P., Chen H., Cheuk R., Chung M.K.,
RA Hayashizaki Y., Ishida J., Kamiya A., Kawai J., Kim C., Lin J., Liu S.X.,
RA Narusaka M., Pham P.K., Sakano H., Sakurai T., Satou M., Seki M., Shinn P.,
RA Yamada K., Shinozaki K., Ecker J., Theologis A., Davis R.W.;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAO30041.1}
RP NUCLEOTIDE SEQUENCE.
RA Southwick A., Nguyen M., Tripp M., Palm C.J., Jones T., Wu T., Carninci P.,
RA Chen H., Cheuk R., Chan M.M., Chang C.H., Dale J.M., Deng J.M.,
RA Hayashizaki Y., Hsuan V.W., Lee J.M., Ishida J., Kamiya A., Kawai J.,
RA Kim C.J., Narusaka M., Onodera C.S., Quach H.L., Sakurai T., Satou M.,
RA Seki M., Shinn P., Tang C.C., Toroumi M., Wong C., Wu H.C., Yamada K.,
RA Yu G., Yuan S., Shinozaki K., Ecker J., Theologis A., Davis R.W.;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AEE35688.1}
RP NUCLEOTIDE SEQUENCE.
RG TAIR;
RA Swarbreck D., Lamesch P., Wilks C., Huala E.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AEE35688.1}
RP NUCLEOTIDE SEQUENCE.
RA Krishnakumar V., Cheng C.-Y., Chan A.P., Schobel S., Kim M., Ferlanti E.S.,
RA Belyaeva I., Rosen B.D., Micklem G., Miller J.R., Vaughn M., Town C.D.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SIMILARITY: Belongs to the 5'(3')-deoxyribonucleotidase family.
CC {ECO:0000256|ARBA:ARBA00009589}.
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DR EMBL; AY092976; AAM12975.1; -; mRNA.
DR EMBL; BT003378; AAO30041.1; -; mRNA.
DR EMBL; CP002684; AEE35688.1; -; Genomic_DNA.
DR RefSeq; NP_177657.2; NM_106177.4.
DR AlphaFoldDB; Q8RWN4; -.
DR SMR; Q8RWN4; -.
DR PaxDb; 3702-AT1G75210-1; -.
DR ProteomicsDB; 175442; -.
DR EnsemblPlants; AT1G75210.1; AT1G75210.1; AT1G75210.
DR GeneID; 843858; -.
DR Gramene; AT1G75210.1; AT1G75210.1; AT1G75210.
DR Araport; AT1G75210; -.
DR TAIR; AT1G75210; -.
DR eggNOG; KOG2469; Eukaryota.
DR HOGENOM; CLU_017845_4_1_1; -.
DR OrthoDB; 3626840at2759; -.
DR BioCyc; ARA:AT1G75210-MONOMER; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8RWN4; baseline and differential.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd07522; HAD_cN-II; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR008380; HAD-SF_hydro_IG_5-nucl.
DR InterPro; IPR023214; HAD_sf.
DR NCBIfam; TIGR02244; HAD-IG-Ncltidse; 1.
DR PANTHER; PTHR12103; 5'-NUCLEOTIDASE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR12103:SF15; CYTOSOLIC PURINE 5'-NUCLEOTIDASE; 1.
DR Pfam; PF05761; 5_nucleotid; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
PE 1: Evidence at protein level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AEE35688.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q8RWN4,
KW ECO:0007829|ProteomicsDB:Q8RWN4};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548}.
SQ SEQUENCE 642 AA; 74314 MW; BF5056656C6059BC CRC64;
MSEWFISRNP TFSTAFPSSC ITVVNPNFIL LSSEFDSYTP QCLFNSLTTT MRLSKRQLSL
PLSLCFSTFS PRSRFHHFPG KYPAPRREFL HTTGTSQLCF KSSMEDQKPS ALSENVLQFH
TVGSRDGCDV PHEWSSPEGG KKIDISNQIF CNRSLNMKNI IAVGFDMDYT LAQYKSETFE
SLAYDGTVRK LVYDLGYPNE LLEWTFDWNY MVRGLVLDKK RGNILKMDRH KYVKVAYHGF
RELSKEDKVE IYGSSLVRDS FDEPDYALID TLFSLAEAYL FAQLVDFKDN NPEKVPKDVD
YARMYKDVRA AVDLCHRDGT LKQMVAKEPN RYINEDTTIV PLIKMIRDSG RSTFLVTNSL
WDYTNIVMNF LCGGRTVHGP HTCNFDWLQY FDVVITGSAK PGFFHEDSRA NLFEVEPQSG
MLINTDNGTP MAQVGDPSPK ILLKSKDKGC RVFQGGNVGH LHSLLSIESS SQVLYVGDHI
YGDILRSKKI LGWRTMLVVP ELEKEVELLW ELRNMRKDLI LMRNERDSVE DKIHHLNWSL
KFEDINENNK HEMLSALKDL ESKRDKVRQS HQQAQRECHQ KFHKVWGQLM KTGYQSSRFA
HQVERFACLY TSQVSNLRLY SPDKYYRPSE DFMSHEFHLL PL
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