GenomeNet

Database: UniProt
Entry: Q8S4P5
LinkDB: Q8S4P5
Original site: Q8S4P5 
ID   EZ2_MAIZE               Reviewed;         894 AA.
AC   Q8S4P5;
DT   19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   13-FEB-2019, entry version 102.
DE   RecName: Full=Histone-lysine N-methyltransferase EZ2;
DE            EC=2.1.1.43;
DE   AltName: Full=Enhancer of zeste protein 2;
GN   Name=EZ2; Synonyms=MEZ2;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae;
OC   PACMAD clade; Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae;
OC   Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY,
RP   AND ALTERNATIVE SPLICING.
RC   TISSUE=Seed;
RX   PubMed=11950982; DOI=10.1104/pp.010742;
RA   Springer N.M., Danilevskaya O.N., Hermon P., Helentjaris T.G.,
RA   Phillips R.L., Kaeppler H.F., Kaeppler S.M.;
RT   "Sequence relationships, conserved domains, and expression patterns
RT   for maize homologs of the Polycomb group genes E(z), esc, and E(Pc).";
RL   Plant Physiol. 128:1332-1345(2002).
CC   -!- FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of some
CC       PcG multiprotein complex, which methylates 'Lys-27' of histone H3,
CC       leading to transcriptional repression of the affected target
CC       genes. PcG proteins are not required to initiate repression, but
CC       to maintain it during later stages of development (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00909};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q8S4P5-1; Sequence=Displayed;
CC       Name=2; Synonyms=as1;
CC         IsoId=Q8S4P5-2; Sequence=VSP_007783;
CC       Name=3; Synonyms=as2;
CC         IsoId=Q8S4P5-3; Sequence=VSP_007784;
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. EZ subfamily. {ECO:0000255|PROSITE-ProRule:PRU00909}.
DR   EMBL; AF443597; AAM13421.1; -; mRNA.
DR   RefSeq; NP_001105650.1; NM_001112180.1. [Q8S4P5-1]
DR   UniGene; Zm.10342; -.
DR   ProteinModelPortal; Q8S4P5; -.
DR   SMR; Q8S4P5; -.
DR   STRING; 4577.GRMZM5G875502_P02; -.
DR   PaxDb; Q8S4P5; -.
DR   GeneID; 542659; -.
DR   KEGG; zma:542659; -.
DR   MaizeGDB; 754843; -.
DR   eggNOG; KOG1079; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   HOGENOM; HOG000083511; -.
DR   KO; K11430; -.
DR   OMA; HRRPRKH; -.
DR   OrthoDB; 875190at2759; -.
DR   Proteomes; UP000007305; Unplaced.
DR   Genevisible; Q8S4P5; ZM.
DR   GO; GO:0031519; C:PcG protein complex; IEA:InterPro.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd00167; SANT; 1.
DR   InterPro; IPR026489; CXC_dom.
DR   InterPro; IPR025778; Hist-Lys_N-MeTrfase_EZ.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR   PANTHER; PTHR22884:SF237; PTHR22884:SF237; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM01114; CXC; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51633; CXC; 1.
DR   PROSITE; PS51576; SAM_MT43_EZ; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Methyltransferase; Nucleus;
KW   Reference proteome; Repressor; S-adenosyl-L-methionine; Transcription;
KW   Transcription regulation; Transferase.
FT   CHAIN         1    894       Histone-lysine N-methyltransferase EZ2.
FT                                /FTId=PRO_0000213999.
FT   DOMAIN      527    577       SANT.
FT   DOMAIN      627    731       CXC. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00970}.
FT   DOMAIN      746    861       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   COMPBIAS     25     28       Poly-Ala.
FT   COMPBIAS     74     77       Poly-Ala.
FT   COMPBIAS    642    718       Cys-rich.
FT   VAR_SEQ     342    894       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:11950982}.
FT                                /FTId=VSP_007783.
FT   VAR_SEQ     625    894       Missing (in isoform 3).
FT                                {ECO:0000303|PubMed:11950982}.
FT                                /FTId=VSP_007784.
SQ   SEQUENCE   894 AA;  99979 MW;  9C2B04E6F80BA113 CRC64;
     MASSSKASDS SQRSKRSDQG MGKDAAAASV VPIHANLTQL IRQVQSGRLA YIKEKLEVNR
     KTLQRHSCSL FDVAAAAEVA SRGTDGGNAL SQRAAERQCG SDLANGIGER DVVSVQEENL
     ATGTLALSSS GATAQRTIVR FVKLPLVEKI PPYTTWIFLD KNQRMADDQS VVGRRRIYYD
     TVGNEALICS DSDEEIPEPE EEKHFFTKGE DHLIWRATQD HGLNQEVVNV LCQFIGATPS
     EIEERSEVLF EKNEKHSGSS DKIESRLSLD KTMDAVLDSF DNLFCRRCLV FDCRLHGCSQ
     NLVFPCEKQP YSFDPDENKK PCGHLCYLRF PQWREGFKEM HDDGLAGGAT YTMESGTASQ
     RVDVNVMYES EDSNRQKGNI RSMTLVGTSG SKIISSVSAE ESTTTPSADI SETENVSSDL
     PPSSLRKHKI SKHGPRYREH SPGKRQKVFT SDISFEGNIM NKLSIPEIRD TRLESRESGG
     DKLRILDEST KKTSRKDMCG ESPATTMENV GRQSNKVSST KNFLESTLSC WSALERDLYL
     KGIEIFGKNS CLIARNLLSG LKTCIEVANY MYNNGAAMAK RPLLNKSISG DFAENEQDYM
     EQDMAARTRI YRRRGRNRKL KYTWKSAGHP TVRKRTDDGK QCYTQYSPCA CQQMCGKDCP
     CADKGTCCEK YCGCSKSCKN KFRGCHCAKS QCRSRQCPCF AASRECDPDV CRNCWVSCGD
     GSLGEPLARG DGYQCGNMKL LLKQQQRILL GRSDVAGWGA FIKNPVNKND YLGEYTGELI
     SHKEADKRGK IYDRANSSFL FDLNDQYVLD AYRKGDKLKF ANHSSNPNCY AKVMLVAGDH
     RVGIYAKEHI EASEELFYDY RYGPDQAPAW ARRPEGSKKD EASVSHRRAH KVAR
//
DBGET integrated database retrieval system