ID Q8SQM4_ENCCU Unreviewed; 408 AA.
AC Q8SQM4;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=GPI-ANCHOR BIOSYNTHESIS PROTEIN {ECO:0000313|EMBL:CAD27091.1};
GN OrderedLocusNames=ECU09_1210 {ECO:0000313|EMBL:CAD27091.1};
OS Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC Encephalitozoon.
OX NCBI_TaxID=284813 {ECO:0000313|EMBL:CAD27091.1, ECO:0000313|Proteomes:UP000000819};
RN [1] {ECO:0000313|EMBL:CAD27091.1, ECO:0000313|Proteomes:UP000000819}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GB-M1 {ECO:0000313|EMBL:CAD27091.1,
RC ECO:0000313|Proteomes:UP000000819};
RX PubMed=11719806; DOI=10.1038/35106579;
RA Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA Vivares C.P.;
RT "Genome sequence and gene compaction of the eukaryote parasite
RT Encephalitozoon cuniculi.";
RL Nature 414:450-453(2001).
CC -!- FUNCTION: Catalytic subunit in the complex catalyzing the transfer of
CC N-acetylglucosamine from UDP-N-acetylglucosamine to
CC phosphatidylinositol, the first step of GPI biosynthesis.
CC {ECO:0000256|ARBA:ARBA00003265}.
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DR EMBL; AL590451; CAD27091.1; -; Genomic_DNA.
DR RefSeq; XP_955672.1; XM_950579.1.
DR AlphaFoldDB; Q8SQM4; -.
DR STRING; 284813.Q8SQM4; -.
DR CAZy; GT4; Glycosyltransferase Family 4.
DR VEuPathDB; MicrosporidiaDB:ECU09_1210; -.
DR HOGENOM; CLU_009583_19_0_1; -.
DR InParanoid; Q8SQM4; -.
DR OMA; QCVLPTM; -.
DR OrthoDB; 24420at2759; -.
DR Proteomes; UP000000819; Chromosome IX.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0017176; F:phosphatidylinositol N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR013234; PIGA_GPI_anchor_biosynthesis.
DR PANTHER; PTHR45871; N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN; 1.
DR PANTHER; PTHR45871:SF1; PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR Pfam; PF08288; PIGA; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000819};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 387..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..128
FT /note="PIGA GPI anchor biosynthesis"
FT /evidence="ECO:0000259|Pfam:PF08288"
FT DOMAIN 184..336
FT /note="Glycosyl transferase family 1"
FT /evidence="ECO:0000259|Pfam:PF00534"
SQ SEQUENCE 408 AA; 46526 MW; D00BD3EAA1FB79D0 CRC64;
MKSLRIAMVS DFFYLLKGGV ETHIKYLSEE LIAMGHKVII ITHRAGNLVG CRMVGNIKVY
FLDIPVLCRN TTFPSLYSNF PLFKEIFDNE EIEIVHGHQT MSNMCIEGLF HARTLNLKTV
ITDHSIFEVG PFENIVVNAL CRLALKNIDR CICVSYTSKE NTHIRTMIPL ERIHVIPNAI
VSDIFRPSEK KHSGGKVVVV VSRLVFRKGI DLLIGAIPLI CKGDRSVRIV IVGDGPMRDG
IEQVLDENEL YDRVEIIHEV DHERVGEIMR RGDVFLNTSL TETFCITIVE AASCGLHVVS
TNVGGIHEIL PPDMITFSRI TPEDIARKVL EVLGKSGHNP QDYNKRLKNV YSWERVARMT
EKVYMEIEKT SLSYRDRRKL YQGVTGFLSR FMITIEYLFL FVLSLRNV
//
