ID Q8SQY6_ENCCU Unreviewed; 581 AA.
AC Q8SQY6;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 124.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN OrderedLocusNames=ECU11_0470 {ECO:0000313|EMBL:CAD25957.1};
OS Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC Encephalitozoon.
OX NCBI_TaxID=284813 {ECO:0000313|EMBL:CAD25957.1, ECO:0000313|Proteomes:UP000000819};
RN [1] {ECO:0000313|EMBL:CAD25957.1, ECO:0000313|Proteomes:UP000000819}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GB-M1 {ECO:0000313|EMBL:CAD25957.1,
RC ECO:0000313|Proteomes:UP000000819};
RX PubMed=11719806; DOI=10.1038/35106579;
RA Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA Vivares C.P.;
RT "Genome sequence and gene compaction of the eukaryote parasite
RT Encephalitozoon cuniculi.";
RL Nature 414:450-453(2001).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
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DR EMBL; AL590450; CAD25957.1; -; Genomic_DNA.
DR RefSeq; NP_586353.1; NM_001042186.1.
DR AlphaFoldDB; Q8SQY6; -.
DR STRING; 284813.Q8SQY6; -.
DR GeneID; 860006; -.
DR KEGG; ecu:ECU11_0470; -.
DR VEuPathDB; MicrosporidiaDB:ECU11_0470; -.
DR HOGENOM; CLU_430888_0_0_1; -.
DR InParanoid; Q8SQY6; -.
DR OMA; LCIEMED; -.
DR OrthoDB; 239968at2759; -.
DR Proteomes; UP000000819; Chromosome XI.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01367; KISc_KIF2_like; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR47971:SF8; KINESIN-LIKE PROTEIN KIF24; 1.
DR PANTHER; PTHR47971; KINESIN-RELATED PROTEIN 6; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF07647; SAM_2; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Reference proteome {ECO:0000313|Proteomes:UP000000819}.
FT DOMAIN 1..63
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 174..485
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 489..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 258..265
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 581 AA; 65177 MW; 74C109E689994662 CRC64;
MKDLRTYLAE NKVEHLYKIF KGLGIDESQL LAKLKYSDLE KIGIENLIER RKVFDIINEI
NQDIYNEDIE MNKNDSYEDS LLSSDFVCKG TDRPGYRIFP GSLAEKSGAM FGSGETISQK
LSLCSMPRKN SPRKSLIGLD GLDIDGSKLN THGACNESLL TSSDTGGLGV KEEKIVVCVR
KKPCSNPKMD VVDIEGRSVV VNEEKFRVDL RPYVEQYRFE FDYSFDGSQK NMDVYRGCVK
SIVNHVISGG LGTILAYGQT GTGKTYTMLE RDTGMMYLAI KDLMAFKSHG AVTFCEIYMG
QVYDLLDNGK RVQLREVNGI VHLSNSREEK FEGYEEALEI IEKGMSLRKT GVTGANSKSS
RSHAVILVNF SEHRAGNEGF QASGSIVFVD LAGSERGSDR KEMGSDVKNE GAEINKSLLA
LKECIRGMEK DKRHLPFRQS KLTQILKNSF IGTSKTCLIA TISPTPENVE HTLNTLRYAA
RIKESVVPKG RRARDSLGGN GIIDQARPPP TTSRKEPEEE SFEHPRLELS RSRDVLVREI
QKALSRIESK IPLLRGSEEL ERMLSLCIEM EDIVDHRTNK Y
//
