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Database: UniProt
Entry: Q8SR63
LinkDB: Q8SR63
Original site: Q8SR63 
ID   RRP3_ENCCU              Reviewed;         400 AA.
AC   Q8SR63;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   31-JUL-2019, entry version 101.
DE   RecName: Full=ATP-dependent rRNA helicase RRP3 {ECO:0000305};
DE            EC=3.6.4.13 {ECO:0000250|UniProtKB:P38712};
GN   Name=RRP3 {ECO:0000250|UniProtKB:P38712};
GN   OrderedLocusNames=ECU10_0440;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M.,
RA   Weissenbach J., Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
CC   -!- FUNCTION: ATP-dependent rRNA helicase required for pre-ribosomal
CC       RNA processing. Involved in the maturation of the 35S-pre-rRNA and
CC       to its cleavage to mature 18S rRNA.
CC       {ECO:0000250|UniProtKB:P38712}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000250|UniProtKB:P38712};
CC   -!- SUBUNIT: Interacts with the SSU processome.
CC       {ECO:0000250|UniProtKB:P38712}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX47/RRP3
CC       subfamily. {ECO:0000305}.
DR   EMBL; AL590449; CAD25763.1; -; Genomic_DNA.
DR   RefSeq; NP_586159.1; NM_001041992.1.
DR   SMR; Q8SR63; -.
DR   GeneID; 859808; -.
DR   KEGG; ecu:ECU10_0440; -.
DR   EuPathDB; MicrosporidiaDB:ECU10_0440; -.
DR   eggNOG; KOG0330; Eukaryota.
DR   eggNOG; ENOG410XQU7; LUCA.
DR   HOGENOM; HOG000268802; -.
DR   InParanoid; Q8SR63; -.
DR   KO; K14777; -.
DR   OMA; KAKNRSI; -.
DR   OrthoDB; 744428at2759; -.
DR   Proteomes; UP000000819; Chromosome X.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    400       ATP-dependent rRNA helicase RRP3.
FT                                /FTId=PRO_0000256036.
FT   DOMAIN       32    202       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      229    373       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND      45     52       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF         1     29       Q motif. {ECO:0000305}.
FT   MOTIF       150    153       DEAD box. {ECO:0000305}.
SQ   SEQUENCE   400 AA;  45226 MW;  8AAA2AAB33E4E957 CRC64;
     MEFGDLRIDE SLIKTCQEKG ITRPTEVQRQ VIPAVLGGGD VIAVSQTGSG KTLAFVLPIV
     SHLLQKNRSF YCLVVAPTRE LSSQIAECFN MFQATGLRVC LLVGGANFNV QANQLSKRPH
     VVVGTPGRIA EHVLKTKSFR TERVRKFVLD EADRFFEQDF VEDLETIIPS LREKRQTLLF
     TATMSDEISK LSSSILKRPK TIRTAEKYET VPALKEYYLF VAMKWKNSAL VELLEMSQGM
     SVIVFVSMCV TARVMSLALA RLGFCSEALH GELSQEKREE AMRSFKESRF NVLVCTDLGS
     RGLDISHVDL VINFDVPKSG KDYIHRVGRT ARAGRSGTAI TLVTQYDVEQ IQKIEFTLEK
     KLEEFKMMKK NFGTICARIE EAIQEAQETL KEERKRNRRP
//
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