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Database: UniProt
Entry: Q8SSU4_DICDI
LinkDB: Q8SSU4_DICDI
Original site: Q8SSU4_DICDI 
ID   Q8SSU4_DICDI            Unreviewed;      1728 AA.
AC   Q8SSU4; Q554R4;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   24-JAN-2024, entry version 117.
DE   SubName: Full=Ras GTPase activation domain-containing protein {ECO:0000313|EMBL:EAL69998.1};
GN   ORFNames=DDB_G0274211 {ECO:0000313|EMBL:EAL69998.1};
OS   Dictyostelium discoideum (Social amoeba).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL69998.1, ECO:0000313|Proteomes:UP000002195};
RN   [1] {ECO:0000313|EMBL:EAL69998.1, ECO:0000313|Proteomes:UP000002195}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4 {ECO:0000313|EMBL:EAL69998.1,
RC   ECO:0000313|Proteomes:UP000002195};
RX   PubMed=12097910; DOI=10.1038/nature00847;
RG   Dictyostelium Genome Sequencing Consortium;
RA   Glockner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2] {ECO:0000313|EMBL:EAL69998.1, ECO:0000313|Proteomes:UP000002195}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4 {ECO:0000313|EMBL:EAL69998.1,
RC   ECO:0000313|Proteomes:UP000002195};
RX   PubMed=15875012; DOI=10.1038/nature03481;
RG   The Dictyostelium discoideum Sequencing Consortium;
RA   Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA   White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA   Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA   Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA   Noegel A.A., Barrell B., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL69998.1}.
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DR   EMBL; AAFI02000012; EAL69998.1; -; Genomic_DNA.
DR   RefSeq; XP_644259.1; XM_639167.1.
DR   AlphaFoldDB; Q8SSU4; -.
DR   SMR; Q8SSU4; -.
DR   STRING; 44689.Q8SSU4; -.
DR   PaxDb; 44689-DDB0233762; -.
DR   GeneID; 8619687; -.
DR   KEGG; ddi:DDB_G0274211; -.
DR   dictyBase; DDB_G0274211; -.
DR   eggNOG; KOG1826; Eukaryota.
DR   HOGENOM; CLU_240072_0_0_1; -.
DR   InParanoid; Q8SSU4; -.
DR   OMA; IVSQKFF; -.
DR   Reactome; R-DDI-5218921; VEGFR2 mediated cell proliferation.
DR   Reactome; R-DDI-5658442; Regulation of RAS by GAPs.
DR   Reactome; R-DDI-8849471; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
DR   Proteomes; UP000002195; Chromosome 2.
DR   InterPro; IPR006869; DUF547.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   PANTHER; PTHR10194:SF132; RAS-GAP DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF04784; DUF547; 1.
DR   Pfam; PF00616; RasGAP; 2.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002195}.
FT   DOMAIN          565..757
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          115..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          198..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          387..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          887..994
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1287..1317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1380..1428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1567..1641
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1705..1728
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        887..903
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        904..922
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        924..994
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1287..1304
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1728 AA;  192335 MW;  D8B4425042FF48EA CRC64;
     MDYPQLLFIK IVGIKNTKLL CGTDGALVCD LVLDGGTTEY QPFDIVLRRP KSNSGIQKNT
     FIFSLPQPAS KFTLTFKKKY NNRPSQQQQL QQQLLLQQQH IAQQQKLLEV ANSTTSINNN
     EQSDSTTTTP TNNNNNNSNN NTDQSNTESI PTTTTTTTTT TTTTTTTETK PPIITNHNNE
     ISLAKVNVAL QYSNSFNRRS SYNSLNPPPS LSLSREIQQS PRLNESQQSE NKNNINIENT
     NENNNSSNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNENSNNNEI
     KTNSSPNSST INIVVPQQHQ HQQTSPINIS LNQQQTLSPT TSNGLISGSP NSTIYSMSTP
     NSPTTDAILS GSPSFIGYNG GNRFTGNNGN ANGTNGTPIS SSYSLSSPTL ATSNNHDDNS
     NDQTSGSGRI EASCRWYKLN LLSSNIGGGP IQQSNSNNNI SSLNNQPQQQ QQQQQQPNGN
     GTTTLASSNS YQSFANLHTN LTNSETESTL SNDDQPDIQL EISYEQSNMH NLARIKSYHK
     ELLDLIVTSK LGLVHSICDS IDITAAQMLA KSLVDVFHTH HKLLHLLKSF IKKEVSQCHD
     PGTLFRSNSV AMKMVVAYGL KSAQHYLQQT LTPLVVDLCN SPLSLEVDPI KLSPGEDIEM
     NIKNLKIVSQ KFFDRIINSI EQCPKSIIEI CYYFKKIVSR KFPTHWKSAV GGFIFLRLFC
     PACVSPEGQA IISPGRVGIT ERRSLILVAK CLQNLSNQVL FNQPYMETIN DFIHNNLPAL
     DDFFMKCASR PTEDQTIDGM FVSEESIFEG IVYLQQFIDK NQEKLFKNLE SNQNIAQVDK
     PKPEKIMEAV DASKKAVLSN SNLVLGKARS NSSGSNNILL NGSNGLNNSS GGIGGSSSSN
     GGKDSSHKKS RSTTEPKEGK SWSKIKQNVI TPIISNFPKS SSSSSSSSNS SGSNGNGNIN
     NNSNITSSPS ISSSNGSVNP PQTSLSPPQP SSQEEEIKIL NYDFEWDKKS RPVHIVVSTL
     LRNITNLLKS NKLSDTQSLK MNGQPVHWSA IQTTNEFSNF SRETNELQSV YFENMQADYI
     TAVFINIFNL MMVHLHFLIG PPNSEMRRKQ YFTYRYNVSG CLYSLSDIQH GILRGNPKNS
     LSRVRQIRGG DKRRQYVIST LDPRIHFALF AVNITIPCMR IFSPETVVED LHKCGEEFCS
     SKIDICIKKK EISLPKVFSH YGTDFGKSRS EMLKWVFQFL TATKRTELLE LLEKPSFLCL
     YRSESWNPII YKTKFINDLD EKITTEKETE KKQQEKDKLL RRKSRSLTHG NRSLTSKKDS
     SVLIQSLKQS SNHSTKQIRA LLNEIVKVIS ESIDLSYIIK IVDILKRTTK QLSFNEWQKS
     NASGGSNGGS CSTTTNQTQH HGEGSNGQQQ QQQQSNNNTT TTTTTTTTTT VPILTKQSTR
     LFGNTQIYCL APIILTNQFT LPLSEFFSIL FTIEKELNKF LDFMEIASFV QSNDISELLL
     DTLNEVTNEM EQLKNTYDLV TPLKLILKQS LNYFSVSITT KSQPVTPNEE NLLANILQEF
     GLDDLNINNN NNNNNNNNNN NNNNNNNNNN NNNNITTTTT TTTSTTKSTT SISSSSPSSF
     SSQSSLSNSQ QNSPTLTSKR QQQLNLLSER IAEIEKQIDK SDSMQSINPI IQKVKKIGKL
     LSLYDEQAMG RFSPRPLSSS INNINNNNIN NNNSNNTTTT TTTSTIHK
//
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