ID Q8SSU4_DICDI Unreviewed; 1728 AA.
AC Q8SSU4; Q554R4;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 24-JAN-2024, entry version 117.
DE SubName: Full=Ras GTPase activation domain-containing protein {ECO:0000313|EMBL:EAL69998.1};
GN ORFNames=DDB_G0274211 {ECO:0000313|EMBL:EAL69998.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL69998.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL69998.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL69998.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=12097910; DOI=10.1038/nature00847;
RG Dictyostelium Genome Sequencing Consortium;
RA Glockner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2] {ECO:0000313|EMBL:EAL69998.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL69998.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL69998.1}.
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DR EMBL; AAFI02000012; EAL69998.1; -; Genomic_DNA.
DR RefSeq; XP_644259.1; XM_639167.1.
DR AlphaFoldDB; Q8SSU4; -.
DR SMR; Q8SSU4; -.
DR STRING; 44689.Q8SSU4; -.
DR PaxDb; 44689-DDB0233762; -.
DR GeneID; 8619687; -.
DR KEGG; ddi:DDB_G0274211; -.
DR dictyBase; DDB_G0274211; -.
DR eggNOG; KOG1826; Eukaryota.
DR HOGENOM; CLU_240072_0_0_1; -.
DR InParanoid; Q8SSU4; -.
DR OMA; IVSQKFF; -.
DR Reactome; R-DDI-5218921; VEGFR2 mediated cell proliferation.
DR Reactome; R-DDI-5658442; Regulation of RAS by GAPs.
DR Reactome; R-DDI-8849471; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
DR Proteomes; UP000002195; Chromosome 2.
DR InterPro; IPR006869; DUF547.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR PANTHER; PTHR10194:SF132; RAS-GAP DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF04784; DUF547; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002195}.
FT DOMAIN 565..757
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 115..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1287..1317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1380..1428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1567..1641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1705..1728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 887..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..922
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1287..1304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1728 AA; 192335 MW; D8B4425042FF48EA CRC64;
MDYPQLLFIK IVGIKNTKLL CGTDGALVCD LVLDGGTTEY QPFDIVLRRP KSNSGIQKNT
FIFSLPQPAS KFTLTFKKKY NNRPSQQQQL QQQLLLQQQH IAQQQKLLEV ANSTTSINNN
EQSDSTTTTP TNNNNNNSNN NTDQSNTESI PTTTTTTTTT TTTTTTTETK PPIITNHNNE
ISLAKVNVAL QYSNSFNRRS SYNSLNPPPS LSLSREIQQS PRLNESQQSE NKNNINIENT
NENNNSSNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNENSNNNEI
KTNSSPNSST INIVVPQQHQ HQQTSPINIS LNQQQTLSPT TSNGLISGSP NSTIYSMSTP
NSPTTDAILS GSPSFIGYNG GNRFTGNNGN ANGTNGTPIS SSYSLSSPTL ATSNNHDDNS
NDQTSGSGRI EASCRWYKLN LLSSNIGGGP IQQSNSNNNI SSLNNQPQQQ QQQQQQPNGN
GTTTLASSNS YQSFANLHTN LTNSETESTL SNDDQPDIQL EISYEQSNMH NLARIKSYHK
ELLDLIVTSK LGLVHSICDS IDITAAQMLA KSLVDVFHTH HKLLHLLKSF IKKEVSQCHD
PGTLFRSNSV AMKMVVAYGL KSAQHYLQQT LTPLVVDLCN SPLSLEVDPI KLSPGEDIEM
NIKNLKIVSQ KFFDRIINSI EQCPKSIIEI CYYFKKIVSR KFPTHWKSAV GGFIFLRLFC
PACVSPEGQA IISPGRVGIT ERRSLILVAK CLQNLSNQVL FNQPYMETIN DFIHNNLPAL
DDFFMKCASR PTEDQTIDGM FVSEESIFEG IVYLQQFIDK NQEKLFKNLE SNQNIAQVDK
PKPEKIMEAV DASKKAVLSN SNLVLGKARS NSSGSNNILL NGSNGLNNSS GGIGGSSSSN
GGKDSSHKKS RSTTEPKEGK SWSKIKQNVI TPIISNFPKS SSSSSSSSNS SGSNGNGNIN
NNSNITSSPS ISSSNGSVNP PQTSLSPPQP SSQEEEIKIL NYDFEWDKKS RPVHIVVSTL
LRNITNLLKS NKLSDTQSLK MNGQPVHWSA IQTTNEFSNF SRETNELQSV YFENMQADYI
TAVFINIFNL MMVHLHFLIG PPNSEMRRKQ YFTYRYNVSG CLYSLSDIQH GILRGNPKNS
LSRVRQIRGG DKRRQYVIST LDPRIHFALF AVNITIPCMR IFSPETVVED LHKCGEEFCS
SKIDICIKKK EISLPKVFSH YGTDFGKSRS EMLKWVFQFL TATKRTELLE LLEKPSFLCL
YRSESWNPII YKTKFINDLD EKITTEKETE KKQQEKDKLL RRKSRSLTHG NRSLTSKKDS
SVLIQSLKQS SNHSTKQIRA LLNEIVKVIS ESIDLSYIIK IVDILKRTTK QLSFNEWQKS
NASGGSNGGS CSTTTNQTQH HGEGSNGQQQ QQQQSNNNTT TTTTTTTTTT VPILTKQSTR
LFGNTQIYCL APIILTNQFT LPLSEFFSIL FTIEKELNKF LDFMEIASFV QSNDISELLL
DTLNEVTNEM EQLKNTYDLV TPLKLILKQS LNYFSVSITT KSQPVTPNEE NLLANILQEF
GLDDLNINNN NNNNNNNNNN NNNNNNNNNN NNNNITTTTT TTTSTTKSTT SISSSSPSSF
SSQSSLSNSQ QNSPTLTSKR QQQLNLLSER IAEIEKQIDK SDSMQSINPI IQKVKKIGKL
LSLYDEQAMG RFSPRPLSSS INNINNNNIN NNNSNNTTTT TTTSTIHK
//