ID Q8T3D2_CAEEL Unreviewed; 3185 AA.
AC Q8T3D2;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE SubName: Full=Vacuolar protein sorting-associated protein 13 {ECO:0000313|EMBL:CAD27608.1};
GN ORFNames=CELE_T08G11.1 {ECO:0000313|EMBL:CAD27608.1}, T08G11.1
GN {ECO:0000313|EMBL:CAD27608.1, ECO:0000313|WormBase:T08G11.1b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAD27608.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAD27608.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAD27608.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR EMBL; BX284601; CAD27608.1; -; Genomic_DNA.
DR RefSeq; NP_740899.1; NM_170907.5.
DR SMR; Q8T3D2; -.
DR EPD; Q8T3D2; -.
DR PeptideAtlas; Q8T3D2; -.
DR EnsemblMetazoa; T08G11.1b.1; T08G11.1b.1; WBGene00011629.
DR GeneID; 172705; -.
DR KEGG; cel:CELE_T08G11.1; -.
DR UCSC; T08G11.1b; c. elegans.
DR AGR; WB:WBGene00011629; -.
DR WormBase; T08G11.1b; CE30353; WBGene00011629; -.
DR HOGENOM; CLU_000135_1_0_1; -.
DR OrthoDB; 199953at2759; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00011629; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR ExpressionAtlas; Q8T3D2; baseline and differential.
DR GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF93; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 2.
DR Pfam; PF06650; VPS13_VAB; 1.
PE 1: Evidence at protein level;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Proteomics identification {ECO:0007829|EPD:Q8T3D2,
KW ECO:0007829|PeptideAtlas:Q8T3D2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..116
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 136..372
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 560..779
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1135..1330
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1962..2447
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2777..2955
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 3049..3167
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 431..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1011..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1338..1381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1531..1557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1364..1379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3185 AA; 356562 MW; 863AE8315C2B185F CRC64;
MVFESLVADL LNRFLGDFVD NLDSSQLNIG IWGGDVKLDN LQVKETALDD FDLPIKLKYG
YLSSLVLKIP WKNLYNEPVI ATVDGLNLIV VPNKGVVYNE EKVAKNIQEI KQKTLARLEE
ARKERRKPKD PQADTFTEKM ITQIIKNLQI SVSNIHVRFE DRYTNRHRPF AMGITLEKLN
FKTTDENWRE TIHKDVVKII YKLVSLQNLA IYWNSSTEFI SDLDDKEAIR KKLQETIHNG
KNGPEGYNYI LEPIQMEAKL KLNQKPETDG SNWKIPKIDL AVDMHALSIA IGKFQYQDVL
LFLEAQERFN AAGQYLKYRP NLNEFKGHYK AWWKFAYTSI LEEKVRRRRN NWSWDRMQKH
RQLVRKYQKA WVRRQTEASP GADVQATIKE AEKKLDVFNV NVARQQAELE IDREGLTRQE
DKPTGWVAWG KSWFGGGGGP TPDKKKGAKD IGSQFQEAMT PEEKAKLFEA IDYQENIPPT
NYPKEFVENK FDFKLGQVAI VVDGAVSMQL LKLVASVEQR PSASAMHVES SIQELRMDGC
GTEIIRVRDP SIPWMSFLLD TNPLKGNYDQ LVKLAVAPIN IKYQAPAINN AIDVFKPPES
VRLNQLTALA MSRYEEVKAR SATGLAYAVE HRSRLVLDVQ IQPARIYVSE GGTYSSEKPT
LLADMGLLSV VTVDNSSVDT SGMNKMAALM EKAYDRFHVK LSNVVIAFAE NVETAENCVF
EKESPLHVLK PTGLDIQIHK SSIDDLKLAK MRVIGDLPNI VIGISDDRLI GLMKLGLSIP
TPKADEKTKA EKELEVPVAK IKDRAKMRTI MEVEEMEEDV TQKEEGGDDD EKEKKKKTSE
QQVQIELDLR LNQIGVVVYR KDAVFCDVSI LKMACKLQMR TFDMVVTAEL GSIKISMPEF
KSLDEKREHL YLIDNDELQG ALMTLKFVQA NPESPFFATE YALTEQSVDF RFTKLAVSLH
QEGVLELKAF GEALQAQLNE LQKNTPEEKK VEETARKISR KLSDSVMSIA SMSRTPSGKE
KRQRKKTVGS ATQEMDVSRN IKQRIKASFG SLALMIGTQK HLETSLAIEN INANVKITEK
AMEVVATLRA ISMKDRTPGA VYKKLLSVTG KEDMLRFDFV QYQRTDEQRA LMKSSDVDMV
VKMRLAQMRF VFLNLWLARL MAWLAPFQNE AVLAAQAAQA AAAEKAATAA QNVKQIMEQS
PPRIQLDVIL EAPFIVVPRL STSRDVIVLH LGRLALKNEI RGDSEYPKAI IDRMDILMTD
CSFGMGVMNE DVSAVSSSCL ILKPISFKLA LQRNLTFAVA KELPEIVVDA HIHSIEAEMS
DADYKTLMQT LSGNLAEGAD LAIPPPPPPS SLESSNTAAA LTSPGKEKEK KDREANAGPP
VIEKSHTRIV FQFVLDKISA VLYEGEAVNG ERKESDAFAA LRLKNVKTSG KIGEDNSIVF
AMSLDAFTMD DERKEKTKIS KLMDKKGSKD DRFLDMSFNQ DAEANKQIRL KMSAFFICLC
PEFLGCLTRF FNVPQSEEQL EKQAVTANVP TKAVSASPSA SSTFTGGTKT SSGPPQPVGT
LAIDCDMHGV EVILVEDSMH PESTQALILS FNVTAASHPN EQTKDTKMNV AVENLTIFSS
YYQSSRRNEV TYQVLTPVRI EALVNMNTER KTTDAVLKMS ALDIKMSPSI IRLLSAVSAE
FSKSSAPGET GSISQKAAKL RKWPNYFDSK PIDHRKYWFF AAPVAQEAVE EELDVTQEDK
SRTDSMIGKE SAKVDIERIS FTLEAGTGAI PVPLIFLDML VNAEAYDWSS AMRVSSGVSV
QMSYYNESVS VWEPIIEPVE NEKGEFERWK LAMTMKSRNK QDSSDSSPQT EVKIEADKML
NVTVTKSLLS LLNKLSEVFA TAAKQITPTK TRHLPGISPF VVLNETGISV KVLDTETIRV
SENGQAVDAT HGEFVDVFLK NRKSDVEDRR LSIEQEEITG DLKFELAGTV RETKIGRAEK
RVIHLPRVSD GGHKWLIVAE TTVENSRRLV TLNSHVKFTN HLSYAVEIYS KRDTTLDLFG
TVEHGETIPL AVPLLFSPSG DIYLKPVDDK YEVSFESLCW HNFEHNRRQA VRCEADSTDG
SFSGIYIDSV VHEEKIQDGI DDQTTSIYHV HLHPPLEFHN NLPFDINIEL PEQKVLGAGM
STLLNVVAGS PVKAWLTYLG EKYVLDMSIP EIKKDVEVVA LNTETGSDEL LLGLHWTSEY
GDQKVYLYAP FWLVNNTDKM LRHVNDDAVQ HLPTENPIIL PFPAIDLSKK KKARVRIENL
SEWSEEFPLD TVGNAARITC KGSEHDFDLT VDIKLCQSGL TKIVTFAPFY LVSNLGKNPM
EIREEGQKGW VDIPAETCVG IWPVERKKRK LMCVRYKEEP EAESLLFPIT ENYETLCHMD
GEAIGVEVSV STGESSVAIH LSSFVPGMCP VQVMNNLTVP VTFGQKGHIK TTVGPNEFAH
FSWSSIIEPK VLEVDIGDWH FEDKLDQNRF GDLQIDKSVR RFSYYSNFLI GRQRVLLFTP
DVDIAKAAYG SWETDVVDMQ AEISLQGFGL SVVDNIVGRE IIYMAISSSD ILWEEEVKKG
RFKPLAVKYM QVLEEKYQAH LVTPNDDYEA MEAFEVNVNR MIMKKKKGKE VKLRRIFEKG
LWACYGKSSQ RTRLHAKINH IQIDNQLDAC IFPRVLSVVP PPKSVIVDNT PKPFIELSLL
QRQPEFSSIA EIEYGHVLIQ EFSVQVDQGL INALLLLISG EVTRKPYGKE MFDEDIKICH
VTLSETASTY RSQRPKSFYN DLHISPIMMH LSFSQGGTSG DVAASGVSMP IQSEMINVLL
RSVGVTLTEL QDVVFKLAYF ERKCVFYSPE QLNSEIISHY AKQFIKQVYV LVLGLDIIGN
PFGLVRDLSA GVEDLFYQPF QGAIQGPEEF AAGVALGVQS MFGHAVGGAA GAVGRITGTV
GKGVAALTFD DDYMKKRQED LNRKPQSFGE GMARGLKGLG MGVVGGITGV VTKPIEGAKQ
EGGFGFVKGV GKGLIGVVTR PVSGVVDFAS GTMNSVRAVA GTNREAGPLR PPRVLREDKI
VKPYSSGDAY GFKVFKDTDR GELAETDEFV TYASISEKMV LIITDRRLVL SKRTDMMGVW
QTEWGSEYCK IKEPEFIPNG VKILLKEKKK GFLGIGSSEG KIITFQNAEK IHPKLAAAYK
KATLA
//
