ID ABCA1_DICDI Reviewed; 877 AA.
AC Q8T5Z7; Q54DT0; Q94479;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 131.
DE RecName: Full=ABC transporter A family member 1;
DE AltName: Full=ABC transporter ABCA.1;
GN Name=abcA1; Synonyms=abcA; ORFNames=DDB_G0291994;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 174-828.
RC STRAIN=AX4;
RA Loomis W.F.;
RL Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC {ECO:0000305}.
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DR EMBL; AF491005; AAL99041.1; -; Genomic_DNA.
DR EMBL; AAFI02000187; EAL61353.1; -; Genomic_DNA.
DR EMBL; U66526; AAB06789.2; -; mRNA.
DR PIR; T18288; T18288.
DR RefSeq; XP_629792.1; XM_629790.1.
DR AlphaFoldDB; Q8T5Z7; -.
DR SMR; Q8T5Z7; -.
DR STRING; 44689.Q8T5Z7; -.
DR TCDB; 3.A.1.211.7; the atp-binding cassette (abc) superfamily.
DR PaxDb; 44689-DDB0191222; -.
DR EnsemblProtists; EAL61353; EAL61353; DDB_G0291994.
DR GeneID; 8628469; -.
DR KEGG; ddi:DDB_G0291994; -.
DR dictyBase; DDB_G0291994; abcA1.
DR eggNOG; KOG0059; Eukaryota.
DR HOGENOM; CLU_000604_19_5_1; -.
DR InParanoid; Q8T5Z7; -.
DR OMA; LAWYFEH; -.
DR PhylomeDB; Q8T5Z7; -.
DR Reactome; R-DDI-1369062; ABC transporters in lipid homeostasis.
DR Reactome; R-DDI-2453902; The canonical retinoid cycle in rods (twilight vision).
DR Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR Reactome; R-DDI-5683826; Surfactant metabolism.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-8963896; HDL assembly.
DR PRO; PR:Q8T5Z7; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR GO; GO:0031288; P:sorocarp morphogenesis; IBA:GO_Central.
DR CDD; cd03263; ABC_subfamily_A; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF205; ABC TRANSPORTER A FAMILY MEMBER 1-RELATED; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..877
FT /note="ABC transporter A family member 1"
FT /id="PRO_0000363833"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 479..499
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 552..788
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 591..598
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 877 AA; 97375 MW; DBEC7C7ECCB343D9 CRC64;
MSTYSRYNDE DEIRNNKISF GDNIKREFLH LKLLLKKNLL VSIRSYFSTG IEILSPIAFI
IILFLISHFG SGNENPIVTY NQELPICKSY GENRCFNIMF SPSNSPSAIA IMEMLGEINN
NSIYSYPSDT GYLPDLNNTI GLKGGLIMMN SIEDSFEFVL AHPNVTIAAV DFLSIPLGFQ
INGAPPKNEP LLKMDGNSLE FNVVVNTTCP NILATCPDYS IAITTAIEKA VITYYSQKIR
NEKIPPPTIS YGSNAFPRYP PEQGAARVWG GLFYYCGSMI SFIFLLYKVS FEKENKLKQG
MVMMGLSVNQ YWISWFITSF TIDILISLIT IIVGLACQLP FFLGSNFFVL IITFSLFTIS
MSSVAFFLLT FIQSTKSAIG IGMGIFIVGS IFQLVFSGMG TMIFELIYQT NSNGALAARI
ILFFIPMFHF TKVLTDIGNV TTNYPLLTYK FSDLSTDLNI GGTVLKTVIP TTGQSICYLL
ALIGVYTVLA WYFEHIIPGN DGTSSPPWFF VLPSYWGLSL KKVRHIPTPY FDDEDVRAAI
TKAHDASNRA PLIICGLSKS YTKLFRPKKT VHAVKYLSLS VEKGTILGFL GSNGCGKSTT
IGMLTGLLEP TAGDALVYGH SVISNIAAVR RITSVVPQHD ILWAEMTARE HLQLFSELKG
IPAQERESQI QKVLDQVRLS KISNNLISTY SGGMKRRLSV AIACIGDPKI IFMDEPTTGV
DPSSKRHLID LVKSIKNDKV IILTSHDMHE VEILADKIVI MNEGVMACNG NSLQLKSKYG
EGYSVNIVAK SPESIPAVVE FVTLSIPGCK FMKQSALQLN FGFPVTIDHQ IIANFFKQLE
EITNDPNNQL MRDWSVSHST LDDVFLKVSH LAKLKTQ
//
