ID Q8T9N5_SCHMA Unreviewed; 106 AA.
AC Q8T9N5;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 164.
DE SubName: Full=Thioredoxin {ECO:0000313|EMBL:AAL79841.1, ECO:0000313|WBParaSite:Smp_008070.1};
OS Schistosoma mansoni (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6183 {ECO:0000313|EMBL:AAL79841.1};
RN [1] {ECO:0000313|EMBL:AAL79841.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NMRI {ECO:0000313|EMBL:AAL79841.1};
RX PubMed=12204228; DOI=10.1016/S0020-7519(02)00108-X;
RA Alger H.M., Sayed A.A., Stadecker M.J., Williams D.L.;
RT "Molecular and enzymatic characterisation of Schistosoma mansoni
RT thioredoxin.";
RL Int. J. Parasitol. 32:1285-1292(2002).
RN [2] {ECO:0007829|PDB:2XBI, ECO:0007829|PDB:2XBQ}
RP X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) IN COMPLEX WITH CALCIUM, AND
RP DISULFIDE BONDS.
RX PubMed=21465612; DOI=10.1002/PRO.634;
RA Boumis G., Angelucci F., Bellelli A., Brunori M., Dimastrogiovanni D.,
RA Miele A.E.;
RT "Structural and functional characterization of Schistosoma mansoni
RT Thioredoxin.";
RL Protein Sci. 20:1069-1076(2011).
RN [3] {ECO:0000313|Proteomes:UP000008854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA Zerlotini A., Dunne D.W., Berriman M.;
RT "A systematically improved high quality genome and transcriptome of the
RT human blood fluke Schistosoma mansoni.";
RL PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN [4] {ECO:0000313|EMBL:AIW52260.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Puerto Rican {ECO:0000313|EMBL:AIW52260.1};
RA Farnell E.J.;
RT "Predicted IgE binding Schistosoma mansoni proteins are the targets of
RT allergy like responses in human infection.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|WBParaSite:Smp_008070.1}
RP IDENTIFICATION.
RC STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_008070.1};
RG WormBaseParasite;
RL Submitted (DEC-2018) to UniProtKB.
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DR EMBL; AF473536; AAL79841.1; -; mRNA.
DR EMBL; KM281672; AIW52260.1; -; mRNA.
DR RefSeq; XP_018653673.1; XM_018798763.1.
DR PDB; 2XBI; X-ray; 1.60 A; A=1-106.
DR PDB; 2XBQ; X-ray; 1.67 A; A/B=1-106.
DR PDB; 2XC2; X-ray; 1.56 A; A=1-106.
DR PDBsum; 2XBI; -.
DR PDBsum; 2XBQ; -.
DR PDBsum; 2XC2; -.
DR STRING; 6183.Q8T9N5; -.
DR EnsemblMetazoa; Smp_008070.1; Smp_008070.1; Smp_008070.
DR GeneID; 8350666; -.
DR KEGG; smm:Smp_008070; -.
DR WBParaSite; Smp_008070.1; Smp_008070.1; Smp_008070.
DR CTD; 8350666; -.
DR eggNOG; KOG0907; Eukaryota.
DR HOGENOM; CLU_090389_14_1_1; -.
DR OMA; MKEWIKQ; -.
DR OrthoDB; 45858at2759; -.
DR Proteomes; UP000008854; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0015035; F:protein-disulfide reductase activity; IEA:InterPro.
DR CDD; cd02947; TRX_family; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR005746; Thioredoxin.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR NCBIfam; TIGR01068; thioredoxin; 1.
DR PANTHER; PTHR46115:SF5; THIOREDOXIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46115; THIOREDOXIN-LIKE PROTEIN 1; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR PRINTS; PR00421; THIOREDOXIN.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS00194; THIOREDOXIN_1; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:2XBI, ECO:0007829|PDB:2XBQ};
KW Calcium {ECO:0007829|PDB:2XC2};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Metal-binding {ECO:0007829|PDB:2XBQ, ECO:0007829|PDB:2XC2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW Zinc {ECO:0007829|PDB:2XBQ, ECO:0007829|PDB:2XC2}.
FT DOMAIN 1..106
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT BINDING 20
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:2XC2"
FT BINDING 46
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0007829|PDB:2XC2"
FT BINDING 49
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0007829|PDB:2XC2"
FT BINDING 106
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:2XBQ"
FT DISULFID 34..37
FT /evidence="ECO:0007829|PDB:2XBI, ECO:0007829|PDB:2XBQ"
SQ SEQUENCE 106 AA; 11924 MW; CBB0C674ABE2F22F CRC64;
MSKLIELKQD GDLESLLEQH KNKLVVVDFF ATWCGPCKTI APLFKELSEK YDAIFVKVDV
DKLEETARKY NISAMPTFIA IKNGEKVGDV VGASIAKVED MIKKFI
//
