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Database: UniProt
Entry: Q8TGZ3_METKA
LinkDB: Q8TGZ3_METKA
Original site: Q8TGZ3_METKA 
ID   Q8TGZ3_METKA            Unreviewed;       307 AA.
AC   Q8TGZ3;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   08-NOV-2023, entry version 100.
DE   SubName: Full=tRNA/rRNA cytosine-C5-methylase {ECO:0000313|EMBL:AAM01888.1};
GN   OrderedLocusNames=MK0673 {ECO:0000313|EMBL:AAM01888.1};
OS   Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC   Archaea; Euryarchaeota; Methanomada group; Methanopyri; Methanopyrales;
OC   Methanopyraceae; Methanopyrus.
OX   NCBI_TaxID=190192 {ECO:0000313|EMBL:AAM01888.1, ECO:0000313|Proteomes:UP000001826};
RN   [1] {ECO:0000313|EMBL:AAM01888.1, ECO:0000313|Proteomes:UP000001826}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938
RC   {ECO:0000313|Proteomes:UP000001826};
RX   PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA   Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA   Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT   monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR   EMBL; AE009439; AAM01888.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TGZ3; -.
DR   STRING; 190192.MK0673; -.
DR   PaxDb; 190192-MK0673; -.
DR   EnsemblBacteria; AAM01888; AAM01888; MK0673.
DR   KEGG; mka:MK0673; -.
DR   HOGENOM; CLU_005316_7_3_2; -.
DR   InParanoid; Q8TGZ3; -.
DR   OMA; FFESIRY; -.
DR   OrthoDB; 14725at2157; -.
DR   Proteomes; UP000001826; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR   GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR031341; Methyltr_RsmF_N.
DR   InterPro; IPR001678; MeTrfase_RsmB/NOP2.
DR   InterPro; IPR011023; Nop2p.
DR   InterPro; IPR023267; RCMT.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; TIGR00446; nop2p; 1.
DR   PANTHER; PTHR22807:SF4; 28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR   Pfam; PF01189; Methyltr_RsmB-F; 1.
DR   Pfam; PF17125; Methyltr_RsmF_N; 1.
DR   PRINTS; PR02008; RCMTFAMILY.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW   ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000001826};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU01023};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01023};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU01023}.
FT   DOMAIN          23..306
FT                   /note="SAM-dependent MTase RsmB/NOP-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51686"
FT   ACT_SITE        231
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT   BINDING         113..119
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT   BINDING         137
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT   BINDING         178
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ   SEQUENCE   307 AA;  34314 MW;  BFD72F6BEB1A63BE CRC64;
     MRYVEEFRER LERIFGDRAE DVYRYLLEGR PPTYVRVNTL KADVEEVVEN LETAGVELAE
     TPLSYAFRVL SSPGPLGSSL EHVAGYLYLQ DLASMVPPEL LDPEPPGPVI DLCAAPGSKT
     TQLAQLLGGE GVVLAVDADP RRVRALVHNV NRLGCVNVIV AHADAARLRI SAPFLLLDPP
     CSGEGTLHRD PHALRTWTPK KPGRFARTQL RLLRAALRML PPGGRLVYST CTFSVEENEL
     VIHEALGNDD RYRIVPSVPR WLEPHTVPGL TEWEGRELRE DLRHAFRIDP ASLESDGFFV
     AVIERRH
//
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