ID Q8THC9_METAC Unreviewed; 2951 AA.
AC Q8THC9;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE SubName: Full=Cell surface protein {ECO:0000313|EMBL:AAM07927.1};
GN OrderedLocusNames=MA_4588 {ECO:0000313|EMBL:AAM07927.1};
OS Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS C2A).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=188937 {ECO:0000313|EMBL:AAM07927.1, ECO:0000313|Proteomes:UP000002487};
RN [1] {ECO:0000313|EMBL:AAM07927.1, ECO:0000313|Proteomes:UP000002487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A
RC {ECO:0000313|Proteomes:UP000002487};
RX PubMed=11932238; DOI=10.1101/gr.223902;
RA Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA Cann I., Graham D.E., Grahame D.A., Guss A., Hedderich R., Ingram-Smith C.,
RA Kuettner C.H., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B.,
RA Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H.,
RA de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L.,
RA Paulsen I., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H.,
RA Lander E., Metcalf W.W., Birren B.;
RT "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT physiological diversity.";
RL Genome Res. 12:532-542(2002).
RN [2] {ECO:0007829|PDB:2L0D}
RP STRUCTURE BY NMR OF 272-376.
RA Cort J., Lee D., Ciccosanti C., Janjua H., Acton T.B., Xiao R.,
RA Everett J.K., Montelione G.T., Kennedy M.A.;
RT "Solution NMR Structure of putative cell surface protein MA_4588 (272-376
RT domain) from Methanosarcina acetivorans, Northeast StructuralGenomics
RT Consortium Target MvR254A.";
RL Submitted (JUN-2010) to the PDB data bank.
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DR EMBL; AE010299; AAM07927.1; -; Genomic_DNA.
DR PDB; 2L0D; NMR; -; A=272-376.
DR PDBsum; 2L0D; -.
DR SMR; Q8THC9; -.
DR STRING; 188937.MA_4588; -.
DR DNASU; 1476482; -.
DR EnsemblBacteria; AAM07927; AAM07927; MA_4588.
DR KEGG; mac:MA_4588; -.
DR HOGENOM; CLU_225877_0_0_2; -.
DR InParanoid; Q8THC9; -.
DR PhylomeDB; Q8THC9; -.
DR Proteomes; UP000002487; Chromosome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IBA:GO_Central.
DR GO; GO:0006518; P:peptide metabolic process; IBA:GO_Central.
DR GO; GO:0016485; P:protein processing; IBA:GO_Central.
DR CDD; cd00146; PKD; 12.
DR Gene3D; 2.60.40.1080; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 14.
DR InterPro; IPR003343; Big_2.
DR InterPro; IPR011635; CARDB.
DR InterPro; IPR018765; DUF2341.
DR InterPro; IPR021779; DUF3344.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR11532:SF57; PEPTIDASE_M14 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11532; PROTEASE M14 CARBOXYPEPTIDASE; 1.
DR Pfam; PF02368; Big_2; 1.
DR Pfam; PF07705; CARDB; 2.
DR Pfam; PF10102; DUF2341; 2.
DR Pfam; PF11824; DUF3344; 3.
DR Pfam; PF18911; PKD_4; 12.
DR SMART; SM00635; BID_2; 1.
DR SMART; SM00089; PKD; 12.
DR SUPFAM; SSF49373; Invasin/intimin cell-adhesion fragments; 1.
DR SUPFAM; SSF49299; PKD domain; 12.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50093; PKD; 12.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:2L0D};
KW Reference proteome {ECO:0000313|Proteomes:UP000002487}.
FT DOMAIN 382..451
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 467..545
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 550..617
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 942..1020
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1025..1094
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1108..1179
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1507..1590
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 2040..2118
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 2125..2195
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 2210..2293
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 2573..2656
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 2660..2727
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 2931..2951
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 2144..2170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2951 AA; 319560 MW; A6301655D2222D25 CRC64;
MTKPKVMNIS SKYAIYILPL LLILLLACTA SALPTVAHDK VQGEMYVSST ANWESKYSTN
NFDVPNGTVV FARYYVGVWA SSATTTSIST IFNGNAFATN PSCYSSGMGV TWIPYDVTDY
VVPGEINTAT INSASWGDGR QYGTTLVVVL KNENKSQIEY WIADGLDWLH YGDYVGDEVD
NSFTYFNGTV DLADVQSANL YSTHLTGYNY EDFNGYSLSD PADSVSGDYF NYIRWDNVKA
SLVAENQTVN VGRGGDAYCS PVFHALSIAY KIPDLVPVSL TPVTVVPNTV NTMTATIENQ
GNKDSTSFNV SLLVDGIVVD TQTVTSLESE NSTNVDFHWT LDGTANSYTL TVNVDPENAV
NEGNESNNTL TALVGTTTAP IPVADFTATP TAGEVPLTVN FTDQSANSPL SWTWDFNNDG
TMDSIMQNPT YTYDTPGNYT VKLTVSNGGG NDEEVKTDYI FVNYKRPIVN FTANLTKGNA
PLTVQFNDTS LNSPTVWYWD FGDNTISTEQ NPVHTYTAAG NYTVNLTVTN AGGSNSSIKT
EYITVGSGVP IANFTANTVS GYTPLEIRFF DTSTINPTSW AWDFGDNTTS TEQNPVHTYI
SPGLYTVNFT VSNDYGSDIK TKANYIYAGK CKFSQNISFS AGGQAIYQQD IMIHRTSGTA
YEENAGGLKI WHVYLGDSCR EDYGDLRFTD ATGTQLTYYL WPDYTSEEAR FCVRLERADQ
PGRLTICYGD PGATTTSNGN ATYFLFDQFD GTALDTTKWE PVQDNGISVS SGGLHISSGT
GNFAEIFSRT AVPSGIILQF RIQSKTYSTS LGFGNRDYTD NGSSIGLESF SSSYNSAIYS
GEAYSNLRWA PPRTWTSKST DGDIIPDTPG GYYTEELVIS PDEPLKERRD GEAWTNSTRY
VGVSGTKPIQ IEHYRKYGKM DLDYILARAY SSTPPSALGL GPIANFTVNM TNGNAPFTVH
FTDSSKNSPA TWIWDFGDNT TSTEQNPVHT YVVAGNYTVN LTVTNSYGSD TGVKTDYISV
GSGVPVANFT TNKTGGNAPL TVKFTDTSTI NPATWIWDFG DNTTSTEQNP VHTYVVAGNY
TVNLTATNSY GSNTCVKIGY ITVGSGVPVA NFTANVTGGY APLTVQFNDT STVNPASWSW
DFGDGNTSTE QHPVHTYMSA GTYTISLTVT NTYGSGTETK VDHIYAGMYE YNQQISYSAS
DRAVYQQDIV VHRSNGTAYE ENADGLKVWH VYLGDNCRDD YGDVRFTDVT GAKLAYYLWP
DYTSEQARFC VRIENTDQPG TLTICYGNPG ITTTSNGNAT YFLFDQFDGT VLDTTKWELV
QNNGISVSSG GLHISSGTGN FAEIFSRTTV PSGIILQFRI QSKTYSTSVG FGNRDYTDNG
SSIGLENYDS SYNSAIYSGE AYSNLRWAPP RTWSSKSTDG DIIPDTPDGY YTEELVISPD
EPLKERRDGG TWTNSTRYVG VSGTKPIQIA HYRKYGKMDL DYILARAYST TPLFASAFSG
EQQTAAPPVA SFTATPIYGF PHTIQFTDKS FNFPTEWTWD FGDGTTSPEQ NPVHTYAADG
NYTITLTATN EYGTDTETKD YEVVTLFAAS LTVSPSSVQL NQSETQYFTA VAVDQLGNVI
SNTSINWSSS NETIGTIDSN GLFTANVPGK VNITASAEGV TGLAEVTVMK ASPDFIVSVV
TSPMYPISHN TVTATIENHG SEDASEVTAN VTIAGNTTTI TVPALAIGSS TTISVKDTAR
WHVGDLVPIT VVVDPGNEID EANETNNVYT KNATISATSQ RYNGGRFSDG YDKVNNLFYA
EGNVGVAVAI SGNYGSQYGV SGVTLTRKFS ADDLDIPAGA TIKSARLYQG STWYGDPGFN
LQFNGHETQE ADAKYGDCIN GQYAFDVTTY LNTTGDNIAV LTSTNSLNKY AYYATVLIVV
YEADSEPYRQ IWVNEGSDCL LADYGADLAW GYTMFDNVST DSLFSARTIT VLESDDGDVN
SINFNGESLP TIKTGGSDPT IKYFSVTDAL QGGENELGVT GPSYFNFANA VLEVTQVTAS
EANFTANVTS GNAPLNVEFT DTSTGTPTSW TWDFGDGKNS TEQNPTHTYT AEGTYTVKLT
VSNSFGSDSE EKTGYITAGS VVLAPVANFS VDQTTGTAPL SVQFTDESTN TPTSWTWEFG
DGKTSTEQNP THTYETIGTY TVKLTATNYG GSNFTIKTDY ITVTSNVSAP VASFTFDENS
GRVPFTVQFT DTTTGSVSSW NWDFGDGGTS NEQNPTHTYV TEGSYNVTLT ATGPGGSNTI
TSTEPVVVSA PLTSDSYNGG IPLTNVQNGT VSGDLWYDSY YAMETSAQKA FTLPSYTDIK
WARLYVDVYD GHMENNYRGN VEISIDADGD STYELQKNET FNTTYSFPGE GGTGPVWLSD
HLNRVTSDYQ MWYDLTGEIS GQTVNVQAIT SKIDSNFDGR VKAMTLVVAY DDGDSDEVYY
WVNQGHDTVN PLDTEYTGST SFGTSTLASG WSSANLTAIY LASVDGIYSF QGTTLTSGTP
QGSYYGDNTW DVSSMLTAGE YSIFTYNKQE EKYYKIPLAL MSVKYAGSGP TAPTAGFSAN
VTEGEVPLTV LFSDESTGSP TAWVWDFGDN ETSSEQSPVH TYSAAGNYTV TLTVTNAAGS
DSEVKTDYII VSESSMPEEP VAAFNANVTE GEVPLTVQFS DESTGSPTSW FWDFGDGANS
TEQNPSHTYP SAGNYTVNLT VENAAGSDFE LKSDYIEVSD ASGSTVTLYF DPTSSSVAEN
ESTEISIVAS NFPAGLSGYN LTVAIDDPAV AEIIDIEYPT WALITENSTL PGTSIYMKTI
DLEDSVKEGA ADVMLATLTV SGKESGSANL SIGVKRLEDD SGDSIEPALL AGTIEVTLLS
PLPDQEYAPK DLDGDGLYED LTGNGEFSFV DIVAYFHNMD WIEENMPVEY FDFNGNGRID
FDDVVDMFGM I
//
