ID   Q8TK58_METAC            Unreviewed;      1156 AA.
AC   Q8TK58;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   27-MAR-2024, entry version 107.
DE   SubName: Full=Phosphorylase {ECO:0000313|EMBL:AAM06921.1};
GN   OrderedLocusNames=MA_3560 {ECO:0000313|EMBL:AAM06921.1};
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937 {ECO:0000313|EMBL:AAM06921.1, ECO:0000313|Proteomes:UP000002487};
RN   [1] {ECO:0000313|EMBL:AAM06921.1, ECO:0000313|Proteomes:UP000002487}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A
RC   {ECO:0000313|Proteomes:UP000002487};
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A., Hedderich R., Ingram-Smith C.,
RA   Kuettner C.H., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B.,
RA   Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H.,
RA   de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L.,
RA   Paulsen I., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H.,
RA   Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
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DR   EMBL; AE010299; AAM06921.1; -; Genomic_DNA.
DR   RefSeq; WP_011023474.1; NC_003552.1.
DR   AlphaFoldDB; Q8TK58; -.
DR   STRING; 188937.MA_3560; -.
DR   EnsemblBacteria; AAM06921; AAM06921; MA_3560.
DR   GeneID; 1475453; -.
DR   KEGG; mac:MA_3560; -.
DR   HOGENOM; CLU_310946_0_0_2; -.
DR   InParanoid; Q8TK58; -.
DR   OrthoDB; 137833at2157; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR   CDD; cd09008; MTAN; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR   Gene3D; 3.40.50.1580; Nucleoside phosphorylase domain; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   PANTHER; PTHR46082:SF6; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR46082; ATP/GTP-BINDING PROTEIN-RELATED; 1.
DR   Pfam; PF13646; HEAT_2; 2.
DR   Pfam; PF01048; PNP_UDP_1; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   SUPFAM; SSF53167; Purine and uridine phosphorylases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002487}.
FT   DOMAIN          864..1144
FT                   /note="Nucleoside phosphorylase"
FT                   /evidence="ECO:0000259|Pfam:PF01048"
SQ   SEQUENCE   1156 AA;  130192 MW;  0280A362DC4BB5C6 CRC64;
     MIDQEEIHKQ CFSDDPKKRV KAVEQLKDNF SLHSNKEKAW NDLIKLANSE DWHVNNNATY
     ALISVFSQVP DKQQAWNDLV KLATGKDSPV RFRAASILSS VFPHVPDQQK AEDDLHKMTI
     DKDSFIRRMA ASVLGSSFTQ VPDKRQAWND LHRMITDEEK DVRRMAASAL GSVFSQVPDK
     QQTWDDLIKL TTDKDNSVRS RAVSALGSAF PHTLDKQKAW DDLHRLTTSN DSSVRSGVAH
     VLGSAFSHVP DKQQAWSDLH RLATDNVNSV RSKAAHTLGS AFSHVPGKQK AWNDLHRLTT
     DEDRFVRCNA AFALGSSFSH VPDKQKAWNE IHKLTTDEDS FVRSGATFAL HFAFSQIPDK
     QQAWDDLIKL TTDENSNVKS RATAALSSVF SDAPDKQKAW NDLHRITTNE NSSIRSSVVS
     ALGPVFSHVP DKQKAWNDLH RLTTDEDSFV RSNAAFAFFF AFSQVPDKQQ AWNDLVRLTT
     DENSNVKYTA VDVLGSAFSQ VPDKQQAWSN LIKLSTDEDN WMRHSAVFAL GSAFSQVPDK
     QQAWSDIRGL TINEDSVVRR ITASALGSAF SHVPDKQKAW NDLHRLSIDK DEDVRIYANH
     SLGKVSIFKA SQAEKEEDYK RELEIAIEFF KKAAQESELS NPSQFCLPFY RSFHTIVFKK
     QEAKEEVDKY LAEAKKAVGG SKSKELLFEA VNNLANALKE VQDLENRDLE EKKGELNYYR
     QYCDRAAELM RDTEGTAPFA TIAMKKGLPI LDRNLKELLE EIQKKAKIAC QVSQGTSTQE
     IACSISKEVQ TWEIGSQEEM AFCVERFIFT LESKIPRLPE NENIFKIINE SKDQKDINKL
     LENASELIEI IPEITIDPER MKPTIGIITA LPKEYAAVNI LLENKKDKYK ISGYGAGRRY
     CLGEILSEEG NKHNLVLATS GMGNNIAATR AALLLEHFPN VKSIIMVGIA GGVPNPYKEN
     VDDHVRLGDI VVSNENGVIQ YDLIKQEIQE ITCRNPPRPP SSSLIEAVRY LEAEEILGNR
     PWEKYIAQSL SQLKIDRPSE DKDILHNSDN QDEIISHPED PKRVNGQPRV FTGPIASANI
     LQKDPNARDK LRDKFKVKAI EMEASGIADA TWNHEVGYLV VRGICDYCDS HKNDEWQQYA
     AVVAAAYTRA LIESIP
//