ID Q8TLK2_METAC Unreviewed; 279 AA.
AC Q8TLK2;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Uroporphyrinogen-III synthase {ECO:0000313|EMBL:AAM06407.1};
GN Name=hemD {ECO:0000313|EMBL:AAM06407.1};
GN OrderedLocusNames=MA_3034 {ECO:0000313|EMBL:AAM06407.1};
OS Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS C2A).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=188937 {ECO:0000313|EMBL:AAM06407.1, ECO:0000313|Proteomes:UP000002487};
RN [1] {ECO:0000313|EMBL:AAM06407.1, ECO:0000313|Proteomes:UP000002487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A
RC {ECO:0000313|Proteomes:UP000002487};
RX PubMed=11932238; DOI=10.1101/gr.223902;
RA Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA Cann I., Graham D.E., Grahame D.A., Guss A., Hedderich R., Ingram-Smith C.,
RA Kuettner C.H., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B.,
RA Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H.,
RA de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L.,
RA Paulsen I., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H.,
RA Lander E., Metcalf W.W., Birren B.;
RT "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT physiological diversity.";
RL Genome Res. 12:532-542(2002).
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DR EMBL; AE010299; AAM06407.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8TLK2; -.
DR STRING; 188937.MA_3034; -.
DR EnsemblBacteria; AAM06407; AAM06407; MA_3034.
DR KEGG; mac:MA_3034; -.
DR HOGENOM; CLU_011276_9_5_2; -.
DR InParanoid; Q8TLK2; -.
DR PhylomeDB; Q8TLK2; -.
DR Proteomes; UP000002487; Chromosome.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR40082; BLR5956 PROTEIN; 1.
DR PANTHER; PTHR40082:SF1; BLR5956 PROTEIN; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002487}.
FT DOMAIN 33..265
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 279 AA; 30686 MW; E5CE712BA944B336 CRC64;
MTNKGMTEEL TAEKIPLLAI MRPESYREKS EAIARDYGFE PVYVPMIQLE GLKDEVFEPF
VQRVVKGTSD YVVFTSANGI TFTLDKLTKP EKEKFIAALK KTRVIAIGPN TEKELVKIGI
EKPFLPGDYS SEGIVEALCP EVKGKTIDLA RSAFGAKVLI EGLEQCGATV YETHVYTLSI
PEGAAQKELI ERTLAGEVDA FAFTSSMMVR GFMKHAEKLG AKDTIKETLS RAVVGAIGTP
TGNTLEKYGV NADVIPEEFT FEALVKAMKK TMKNQLKSN
//
