ID Q8TU70_METAC Unreviewed; 1274 AA.
AC Q8TU70;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE SubName: Full=Signal-transducing histidine kinase {ECO:0000313|EMBL:AAM03656.1};
GN OrderedLocusNames=MA_0203 {ECO:0000313|EMBL:AAM03656.1};
OS Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS C2A).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=188937 {ECO:0000313|EMBL:AAM03656.1, ECO:0000313|Proteomes:UP000002487};
RN [1] {ECO:0000313|EMBL:AAM03656.1, ECO:0000313|Proteomes:UP000002487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A
RC {ECO:0000313|Proteomes:UP000002487};
RX PubMed=11932238; DOI=10.1101/gr.223902;
RA Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA Cann I., Graham D.E., Grahame D.A., Guss A., Hedderich R., Ingram-Smith C.,
RA Kuettner C.H., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B.,
RA Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H.,
RA de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L.,
RA Paulsen I., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H.,
RA Lander E., Metcalf W.W., Birren B.;
RT "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT physiological diversity.";
RL Genome Res. 12:532-542(2002).
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DR EMBL; AE010299; AAM03656.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8TU70; -.
DR STRING; 188937.MA_0203; -.
DR EnsemblBacteria; AAM03656; AAM03656; MA_0203.
DR KEGG; mac:MA_0203; -.
DR HOGENOM; CLU_000445_114_57_2; -.
DR InParanoid; Q8TU70; -.
DR PhylomeDB; Q8TU70; -.
DR Proteomes; UP000002487; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00130; PAS; 5.
DR Gene3D; 2.10.70.100; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 5.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR025847; MEDS_domain.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR011495; Sig_transdc_His_kin_sub2_dim/P.
DR NCBIfam; TIGR00229; sensory_box; 5.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR PANTHER; PTHR43065:SF23; SENSOR HISTIDINE KINASE PDTAS-RELATED; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07568; HisKA_2; 1.
DR Pfam; PF14417; MEDS; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF08448; PAS_4; 2.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00086; PAC; 5.
DR SMART; SM00091; PAS; 5.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 5.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 5.
DR PROSITE; PS50112; PAS; 5.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:AAM03656.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002487};
KW Transferase {ECO:0000313|EMBL:AAM03656.1}.
FT DOMAIN 217..287
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 276..339
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 521..567
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 595..646
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 700..744
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 746..798
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 795..864
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 868..920
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 921..991
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 993..1045
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 1053..1271
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 497..531
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 634..682
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 904..931
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1274 AA; 144136 MW; 1E1D0856818AA589 CRC64;
MYHQNWRKYG MRKYLRNSGI DIVGNVSFGT HFCQFYQTKE DLMDMLVPYF KAGLESNEFC
MWVTSQPLEV EKAKKALRKS VPDLDIYLEK GQIEIIPCTC WYLNEGIFDS RRILNGYVEK
LDQALANGYD GLRLSESTFW GGKKDWNNFV NYEKEIDRVI GNYHMLALST CPLDRCSATE
IIEVVSSHQF SLIKKEGKWE REDNFGRKKA EEAAVRDAGD WEQTFDAIPD LIAILDTEYQ
IVRANRAMAV KLGVTPEECI GQTCYRIIHG KSKPPSSCPH RQLLKDGAEH TAEVYEDCLG
GYSIVSVSPL YDSKGKLTGS IHVARDINER KQEEHRIHRY NRILGEINRI FSNVVQAKTE
KELGNACLSV ALEMTGSQIG FIGELGIDGI LHDIAISESG LDQCLMYDKT GHRYRPGVLV
VHGLYGSVVN SGKSFFTNDP PSHFDSIGVP NGHPPLTSFL GVPLVQDGKT IGVLTVANRE
GGYSCEQQED LEAIAPAVTQ ALQRKKAEQE RKRAEEALIR RENEFRTLAE NSPDMIARFD
RQNHHTYVNP AAAEVYDLSQ EEIIGKTHSE LGRNLKHVTF WEKHNEKVFT TGNSETMEFH
YTSSQGKECH FNTRIVPEFV NGKVTSVLAI SRDITDIKEA EAKLKETLDN LENLVKERTA
QLEKAYNLLK ENEKGLAEAQ RMAHLGNWDW NLVTGEIHCS DELYRIFGLN PREFSTICSE
ALSYVHPDDR DHVNDAIKKA LDGKPCSIDF RIISTDGAER IVHAQGEVVC DEKNTPVRIK
GIVQDITERK RAEEKIQILA NAVESSDDAI ITKSLDGIIT SWNKGAEKVY GYSAEEVLGK
PISILEPSFF GGETKKLTEM VKQGERVHHH ETMRLRKDGT RISVSMALSP VFDIHGNLTA
ISAITRDITE SKRAEDKLRE SEEKYRNIVE TANEGVLIID DNAMITYANK KMTDMSGYRL
EEGIGRSIWD FISEGSKAIA KLNLKRRRQG ANGSYELKLI RGDGSPLWVL INAKSLFDKD
GKFAGSLSML TDVTERKEAE ETLANLEIAR KKEIHHRIKN NLQVISSLLD LQAEKFNSRE
DIKDSEVLEA FRESQDRVIS MALIHEELYK GGEFDTLDFS SYIEELTENL FLTYRLGNTD
ISLNMDLEEN IFFDMDTAVP LGMIINELVS NSFKYAFQGR NRGEIRIKFR REENGKYINS
GVKSKNGGCK SNNFTLTVSD NGVGIPENFD IEDLDSLGFQ LITSLVDQLD GKLELKRNNG
TEFTVRFTVR DKNE
//
