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Database: UniProt
Entry: Q8TWE9_METKA
LinkDB: Q8TWE9_METKA
Original site: Q8TWE9_METKA 
ID   Q8TWE9_METKA            Unreviewed;       390 AA.
AC   Q8TWE9;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   24-JAN-2024, entry version 113.
DE   SubName: Full=Ferredoxin domain fused to pyruvate-formate lyase-activating enzyme {ECO:0000313|EMBL:AAM02299.1};
GN   OrderedLocusNames=MK1086 {ECO:0000313|EMBL:AAM02299.1};
OS   Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC   Archaea; Euryarchaeota; Methanomada group; Methanopyri; Methanopyrales;
OC   Methanopyraceae; Methanopyrus.
OX   NCBI_TaxID=190192 {ECO:0000313|EMBL:AAM02299.1, ECO:0000313|Proteomes:UP000001826};
RN   [1] {ECO:0000313|EMBL:AAM02299.1, ECO:0000313|Proteomes:UP000001826}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938
RC   {ECO:0000313|Proteomes:UP000001826};
RX   PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA   Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA   Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT   monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR   EMBL; AE009439; AAM02299.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TWE9; -.
DR   STRING; 190192.MK1086; -.
DR   PaxDb; 190192-MK1086; -.
DR   EnsemblBacteria; AAM02299; AAM02299; MK1086.
DR   KEGG; mka:MK1086; -.
DR   PATRIC; fig|190192.8.peg.1141; -.
DR   HOGENOM; CLU_690041_0_0_2; -.
DR   InParanoid; Q8TWE9; -.
DR   OMA; CNLRCPQ; -.
DR   OrthoDB; 371936at2157; -.
DR   Proteomes; UP000001826; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 3.30.70.20; -; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR   InterPro; IPR034457; Organic_radical-activating.
DR   InterPro; IPR007197; rSAM.
DR   PANTHER; PTHR30352:SF5; PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME; 1.
DR   PANTHER; PTHR30352; PYRUVATE FORMATE-LYASE-ACTIVATING ENZYME; 1.
DR   Pfam; PF00111; Fer2; 1.
DR   Pfam; PF00037; Fer4; 1.
DR   Pfam; PF13353; Fer4_12; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR   SMART; SM00729; Elp3; 1.
DR   SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Lyase {ECO:0000313|EMBL:AAM02299.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Pyruvate {ECO:0000313|EMBL:AAM02299.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001826};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT   DOMAIN          25..54
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          151..379
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
SQ   SEQUENCE   390 AA;  43064 MW;  64297CE8BDEDAC7F CRC64;
     MVRKVRLVGC RHCGYCSQVV DCPVGDPLWN REDCVGCGAC VPACPYGARR LVEVEEGPIT
     VRVDGEEVEV ESRWVEGALR EIGHDVDAPC GVGGCYACAV RLNGEVVPAC NSKLTEGDEV
     ETEDVDGKIR VVSGFQPHPV GGVGTPVELK DKPGYVEAAC FAHGCNLRCP QCQNHSIAFG
     AAMGARMRPE EAARLLVGTA REYGVNRVAI SGGEPTLNRE FLVEFVRKCR EYGGPDLRVH
     VDTNGTVLSP DYVDELVEAG MTDIGIDVKG FRPETFAEVA GIDVKGAAEY VDGVLRILEY
     LADEYLEEVF VGVGIPYNPE LVDKEEVFAL TDWLYEHLGE DVQVCYLDYR PEFRRRDLPL
     PKYEDMVELE EYARSLGFRR VHAQKVSVRR
//
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