ID Q8TWR3_METKA Unreviewed; 352 AA.
AC Q8TWR3;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Predicted N6-adenine-specific RNA methylase containing THUMP domain {ECO:0000313|EMBL:AAM02182.1};
GN OrderedLocusNames=MK0969 {ECO:0000313|EMBL:AAM02182.1};
OS Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC Archaea; Euryarchaeota; Methanomada group; Methanopyri; Methanopyrales;
OC Methanopyraceae; Methanopyrus.
OX NCBI_TaxID=190192 {ECO:0000313|EMBL:AAM02182.1, ECO:0000313|Proteomes:UP000001826};
RN [1] {ECO:0000313|EMBL:AAM02182.1, ECO:0000313|Proteomes:UP000001826}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938
RC {ECO:0000313|Proteomes:UP000001826};
RX PubMed=11930014; DOI=10.1073/pnas.032671499;
RA Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA Koonin E.V., Kozyavkin S.A.;
RT "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT monophyly of archaeal methanogens.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
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DR EMBL; AE009439; AAM02182.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8TWR3; -.
DR STRING; 190192.MK0969; -.
DR PaxDb; 190192-MK0969; -.
DR EnsemblBacteria; AAM02182; AAM02182; MK0969.
DR KEGG; mka:MK0969; -.
DR PATRIC; fig|190192.8.peg.1014; -.
DR HOGENOM; CLU_032119_0_0_2; -.
DR InParanoid; Q8TWR3; -.
DR OrthoDB; 7080at2157; -.
DR Proteomes; UP000001826; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006400; P:tRNA modification; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11715; THUMP_AdoMetMT; 1.
DR Gene3D; 3.30.2130.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14911:SF22; TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SMART; SM00981; THUMP; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF143437; THUMP domain-like; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51165; THUMP; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AAM02182.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001826};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000313|EMBL:AAM02182.1}.
FT DOMAIN 51..168
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
SQ SEQUENCE 352 AA; 39227 MW; F4A674A0CE59134E CRC64;
MTSGVLCTTA PGLEDVCAQE LGEITGKSVR ENYLGVRGRV LVECSEHEAL DLAREINRRS
LTVHRAAVLL GGFEIEHRDE RGLEEIRERC RELPFERYIH EHDTFGVRPS RLGEHDFTSV
DVGAAVGDAV IERIKREEGF RPQVDLDAPS VIVRADVVGD TVIVGVCTTG DRSLHQRGYR
VYDHPAALNP VIAQGMLELA GDPDSLIDPT CGGATVPIEA LLRDPETEAV GVEKFRTHYE
GARLNVLAAR VDVELYLADA TRLFEEVPEL RDREFDAAVF NPPYGLKIAN PRVVKTLYRG
LARVLSDLVS VVVTVTPRDG WMRAAMEEYG FRLSHDRWVR HGGLDVRLLV FR
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