ID Q8TZ60_METKA Unreviewed; 270 AA.
AC Q8TZ60;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Prephenate dehydratase {ECO:0000313|EMBL:AAM01296.1};
GN Name=tyrA_1 {ECO:0000313|EMBL:AAM01296.1};
GN OrderedLocusNames=MK0079 {ECO:0000313|EMBL:AAM01296.1};
OS Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC Archaea; Euryarchaeota; Methanomada group; Methanopyri; Methanopyrales;
OC Methanopyraceae; Methanopyrus.
OX NCBI_TaxID=190192 {ECO:0000313|EMBL:AAM01296.1, ECO:0000313|Proteomes:UP000001826};
RN [1] {ECO:0000313|EMBL:AAM01296.1, ECO:0000313|Proteomes:UP000001826}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938
RC {ECO:0000313|Proteomes:UP000001826};
RX PubMed=11930014; DOI=10.1073/pnas.032671499;
RA Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA Koonin E.V., Kozyavkin S.A.;
RT "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT monophyly of archaeal methanogens.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
CC -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
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DR EMBL; AE009439; AAM01296.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8TZ60; -.
DR STRING; 190192.MK0079; -.
DR PaxDb; 190192-MK0079; -.
DR EnsemblBacteria; AAM01296; AAM01296; MK0079.
DR KEGG; mka:MK0079; -.
DR HOGENOM; CLU_035008_0_2_2; -.
DR InParanoid; Q8TZ60; -.
DR OrthoDB; 8755at2157; -.
DR Proteomes; UP000001826; Chromosome.
DR GO; GO:0004664; F:prephenate dehydratase activity; IEA:InterPro.
DR GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd04905; ACT_CM-PDT; 1.
DR CDD; cd13630; PBP2_PDT_1; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR001086; Preph_deHydtase.
DR InterPro; IPR018528; Preph_deHydtase_CS.
DR PANTHER; PTHR21022; PREPHENATE DEHYDRATASE P PROTEIN; 1.
DR PANTHER; PTHR21022:SF19; PREPHENATE DEHYDRATASE-RELATED; 1.
DR Pfam; PF01842; ACT; 1.
DR Pfam; PF00800; PDT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Phenylalanine biosynthesis {ECO:0000256|ARBA:ARBA00023222};
KW Reference proteome {ECO:0000313|Proteomes:UP000001826}.
FT DOMAIN 1..177
FT /note="Prephenate dehydratase"
FT /evidence="ECO:0000259|PROSITE:PS51171"
FT DOMAIN 189..266
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 270 AA; 30050 MW; 7B5B4DED9D8CFC67 CRC64;
MISYLGPPGT FTEEAAERFS EEELGGNGKL QSARTITAVF SRVERGEADY GVVPWENSLE
GSVGETLDNF LHRSVRVFGE LVLPIVHALM SGSEPDDREP VVYSHPQAYE QARETLRELL
GNHEFVPTAS TAEAAKLASK EGAYALGPPR LAERFGLDIM EEIRLENNET RFAIISRRDR
APTKEDKTSV VFSVTDRPGA LREILGIFAD RGINLTKIES RPAKRGLGDY VFFLDFEGHR
MLYPGSEALA ELRERTPFSK VLGSYPKVFP
//
