ID Q8TZU4_PYRFU Unreviewed; 318 AA.
AC Q8TZU4;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 131.
DE SubName: Full=Daunorubicin resistance ATP-binding protein drrA {ECO:0000313|EMBL:AAL82013.1};
GN OrderedLocusNames=PF1889 {ECO:0000313|EMBL:AAL82013.1};
OS Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=186497 {ECO:0000313|EMBL:AAL82013.1, ECO:0000313|Proteomes:UP000001013};
RN [1] {ECO:0000313|EMBL:AAL82013.1, ECO:0000313|Proteomes:UP000001013}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1
RC {ECO:0000313|Proteomes:UP000001013};
RX PubMed=10430560;
RA Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA DiRuggiero J., Robb F.T.;
RT "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT horikoshii inferred from complete genomic sequences.";
RL Genetics 152:1299-1305(1999).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE009950; AAL82013.1; -; Genomic_DNA.
DR RefSeq; WP_011013028.1; NZ_CP023154.1.
DR AlphaFoldDB; Q8TZU4; -.
DR STRING; 186497.PF1889; -.
DR PaxDb; 186497-PF1889; -.
DR GeneID; 41713709; -.
DR KEGG; pfu:PF1889; -.
DR PATRIC; fig|186497.12.peg.1960; -.
DR eggNOG; arCOG00194; Archaea.
DR HOGENOM; CLU_000604_1_2_2; -.
DR OrthoDB; 31298at2157; -.
DR PhylomeDB; Q8TZU4; -.
DR Proteomes; UP000001013; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043215; P:daunorubicin transport; IEA:InterPro.
DR GO; GO:1900753; P:doxorubicin transport; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR005894; DrrA.
DR InterPro; IPR025302; DUF4162.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01188; drrA; 1.
DR PANTHER; PTHR42711; ABC TRANSPORTER ATP-BINDING PROTEIN; 1.
DR PANTHER; PTHR42711:SF5; NOD FACTOR EXPORT ATP-BINDING PROTEIN I; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF13732; DUF4162; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:AAL82013.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001013};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 4..247
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 318 AA; 36357 MW; 988882820247EFB9 CRC64;
MKVVEVKDLR KLYPKKIPLP FRKVEYFEAL KGITFSVKKG ELFGLLGPNG AGKTTTIKIL
TTLLEPTSGV AKVLGYDVVK EPREIRRRIN LVAEGERTLY WRLSGYENLR YFASIYYVPR
REAEKRIKEL LEMVGLWERR NDLVMNYSRG MKQRLAIAKA LINDPEVLFL DEPTLGLDVQ
SAVFVRELVR KLVDEEGKTV LLTTHYMQEA EELCDRIAII DHGRIIALDT PEGLKKMVRD
NTIVEVKVRN YPGSNPFGLA KVEEQEGVAI LRGSIDEEEI PRLVEFLVKN NAKVLSVEVE
EPTLEDVFIK LTGRGLRD
//
