ID   Q8U0T0_PYRFU            Unreviewed;       980 AA.
AC   Q8U0T0;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   27-MAR-2024, entry version 121.
DE   SubName: Full=Large helicase-related protein {ECO:0000313|EMBL:AAL81628.1};
GN   OrderedLocusNames=PF1504 {ECO:0000313|EMBL:AAL81628.1};
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497 {ECO:0000313|EMBL:AAL81628.1, ECO:0000313|Proteomes:UP000001013};
RN   [1] {ECO:0000313|EMBL:AAL81628.1, ECO:0000313|Proteomes:UP000001013}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1
RC   {ECO:0000313|Proteomes:UP000001013};
RX   PubMed=10430560;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
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DR   EMBL; AE009950; AAL81628.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8U0T0; -.
DR   STRING; 186497.PF1504; -.
DR   PaxDb; 186497-PF1504; -.
DR   KEGG; pfu:PF1504; -.
DR   PATRIC; fig|186497.12.peg.1567; -.
DR   eggNOG; arCOG00557; Archaea.
DR   HOGENOM; CLU_002025_0_0_2; -.
DR   PhylomeDB; Q8U0T0; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013701; DEAD/DEAH_assoc.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR017170; Lhr-like_ATP-dep_RNA_helic_prd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR47962:SF5; ATP-DEPENDENT HELICASE LHR-RELATED; 1.
DR   PANTHER; PTHR47962; ATP-DEPENDENT HELICASE LHR-RELATED-RELATED; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08494; DEAD_assoc; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   PIRSF; PIRSF037307; Lhr-like_helic_prd; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000313|EMBL:AAL81628.1};
KW   Hydrolase {ECO:0000313|EMBL:AAL81628.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001013}.
FT   DOMAIN          90..267
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          302..450
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   980 AA;  112588 MW;  F244EF8F6681C653 CRC64;
     MHKYFFPLPA TKSTFLLPAD LTTANPCFSK SLINSLSAWA PFLYIQCFSY LPLINFLNSL
     TYPLEMHILI KKAIKERFGK LNALQQLAFH KIRGEGKSVL IIAPTGSGKT EAAVIPILDA
     ILRENLKPIA AIYIAPLKAL NRDLLERLKW WEEKTGVIIE VRHGDTPTSK RLKQVKNPPH
     LLITTPEMLP AILTTKSFRP YLKNTKFIVI DEIGELIENK RGTQLILNLK RLELITEDKP
     IRIGLSATIG SEEKVRLWME ADEVVKPRLK KKYKFTVLYP QPIPEDEKLA EELKVPIEVA
     TRLRVVWDIV EKHKKVLIFV NTRQFAEILG HRLKAWGKPV EVHHGSLSRE ARIEAEKKLK
     EGKIKALICT SSMELGIDIG DVDAVIQYMS PRQVNRLVQR AGRSKHRLWE TSEAYIITTN
     VEDYLQSLAI AKLALEGKLE DVNPYENALD VLAHFIVGLT IEYRNVNITE PYSLAKSTYP
     YRKLSWEDYQ KVLEILEEAR IIRRDGDAIK LGKNAFKYYF ENLSTIPDEI SYAVIDIASG
     KSVGRLDENF VTELEESMEF IMHGRSWIVL EINEKERIIK VKESNNLESA LPSWEGELIP
     VPLEVAEFVG KLKRELLWDK ERALKLLEGV EFNKEELEVA ISQLVESEPV ASDRDIIIES
     YPKFVIIHAD FGNKINEGLT RFISVFLSAR YGNIFLPRSQ AHGIIIRSPF RLNPEEIKEI
     LLMKAEVGDI VARGIRDTPI YRWKMSAIAK RFGALRRDAR IKKVERLFEG TIIEKETFNE
     IYHDKIDIDK TEKILEKIRK GEIRMKTLFR EEITPLSSSL ATLGGEFLIR DILTQEEVEE
     IFREKLLDAE LVMVCTNCGF SWRTKVRRVM DRVNELSCPK CDSKMIAPLH PKDSETFISA
     LKKLKRGEKL SREEEKYYLR GLKAADLLKA YGKDALLALA TYGVGVESAT RILRDYRGKS
     LIKALIEAEK HYIQTRKFWE
//