GenomeNet

Database: UniProt
Entry: Q8VDV0
LinkDB: Q8VDV0
Original site: Q8VDV0 
ID   ITGBL_MOUSE             Reviewed;         494 AA.
AC   Q8VDV0; Q8BKJ4; Q8BMS0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   10-APR-2019, entry version 120.
DE   RecName: Full=Integrin beta-like protein 1;
DE   Flags: Precursor;
GN   Name=Itgbl1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J; TISSUE=Skin, and Spinal ganglion;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8VDV0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8VDV0-2; Sequence=VSP_032005, VSP_032006;
CC   -!- DOMAIN: Contains ten tandem EGF-like repeats strikingly similar to
CC       those found in the cysteine rich 'stalk-like' structure of
CC       integrin beta-subunits.
DR   EMBL; AK029068; BAC26275.1; -; mRNA.
DR   EMBL; AK051773; BAC34761.1; -; mRNA.
DR   EMBL; CT033773; CAP19194.1; -; Genomic_DNA.
DR   EMBL; AC154590; CAP19194.1; JOINED; Genomic_DNA.
DR   EMBL; AC160988; CAP19194.1; JOINED; Genomic_DNA.
DR   EMBL; AC161001; CAP19194.1; JOINED; Genomic_DNA.
DR   EMBL; BC020152; AAH20152.1; -; mRNA.
DR   CCDS; CCDS27354.1; -. [Q8VDV0-1]
DR   RefSeq; NP_663442.2; NM_145467.2. [Q8VDV0-1]
DR   UniGene; Mm.383176; -.
DR   ProteinModelPortal; Q8VDV0; -.
DR   SMR; Q8VDV0; -.
DR   STRING; 10090.ENSMUSP00000059019; -.
DR   PhosphoSitePlus; Q8VDV0; -.
DR   PaxDb; Q8VDV0; -.
DR   PRIDE; Q8VDV0; -.
DR   Ensembl; ENSMUST00000049681; ENSMUSP00000059019; ENSMUSG00000032925. [Q8VDV0-1]
DR   Ensembl; ENSMUST00000142161; ENSMUSP00000121659; ENSMUSG00000032925. [Q8VDV0-2]
DR   GeneID; 223272; -.
DR   KEGG; mmu:223272; -.
DR   UCSC; uc007vbu.2; mouse. [Q8VDV0-1]
DR   CTD; 9358; -.
DR   MGI; MGI:2443439; Itgbl1.
DR   eggNOG; KOG1226; Eukaryota.
DR   eggNOG; ENOG410XP60; LUCA.
DR   GeneTree; ENSGT00950000182617; -.
DR   HOGENOM; HOG000113115; -.
DR   HOVERGEN; HBG052797; -.
DR   InParanoid; Q8VDV0; -.
DR   OMA; CQYPTHC; -.
DR   OrthoDB; 18592at2759; -.
DR   PhylomeDB; Q8VDV0; -.
DR   TreeFam; TF332636; -.
DR   PRO; PR:Q8VDV0; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   Bgee; ENSMUSG00000032925; Expressed in 160 organ(s), highest expression level in aorta.
DR   ExpressionAtlas; Q8VDV0; baseline and differential.
DR   Genevisible; Q8VDV0; MM.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; HDA:BHF-UCL.
DR   GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR   GO; GO:0008305; C:integrin complex; IBA:GO_Central.
DR   GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR   GO; GO:0033627; P:cell adhesion mediated by integrin; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR013111; EGF_extracell.
DR   InterPro; IPR027070; Integrin_b-like_p1.
DR   InterPro; IPR015812; Integrin_bsu.
DR   PANTHER; PTHR10082; PTHR10082; 1.
DR   PANTHER; PTHR10082:SF3; PTHR10082:SF3; 1.
DR   Pfam; PF07974; EGF_2; 3.
DR   SMART; SM00181; EGF; 6.
DR   PROSITE; PS00022; EGF_1; 5.
DR   PROSITE; PS01186; EGF_2; 5.
DR   PROSITE; PS00243; INTEGRIN_BETA; 9.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; EGF-like domain;
KW   Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   CHAIN        24    494       Integrin beta-like protein 1.
FT                                /FTId=PRO_0000323023.
FT   REPEAT       51     95       I.
FT   REPEAT       96    142       II.
FT   REPEAT      143    184       III.
FT   REPEAT      185    230       IV.
FT   REPEAT      231    275       V.
FT   REPEAT      276    326       VI.
FT   REPEAT      327    367       VII.
FT   REPEAT      368    414       VIII.
FT   REPEAT      415    454       IX.
FT   REPEAT      455    494       X.
FT   REGION       51    494       Cysteine-rich tandem repeats.
FT   CARBOHYD    405    405       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VAR_SEQ     197    210       HGKCYCGNCYCEAG -> QGKGHIGCLICIII (in
FT                                isoform 2).
FT                                {ECO:0000303|PubMed:16141072}.
FT                                /FTId=VSP_032005.
FT   VAR_SEQ     211    494       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:16141072}.
FT                                /FTId=VSP_032006.
FT   CONFLICT     95     95       I -> V (in Ref. 3; AAH20152).
FT                                {ECO:0000305}.
SQ   SEQUENCE   494 AA;  53978 MW;  6192CDC83E7F9005 CRC64;
     MHPPGFRNFL LLVSSLLFIG LSAAPQSFLP SLRSLSGAPC RLSRAESERR CRAPGQPPGS
     ALCHDRGRCE CGVCICHVTE PGTYFGPLCE CHEWICETYD GKTCAGHGNC DCGKCKCDVG
     WSGEACQYPT KCDLTKKISN QMCKNSQDVI CSNAGTCHCG RCKCDNSDGH GLIYGKFCEC
     DDRECIDDET EEVCGGHGKC YCGNCYCEAG WHGDKCEFQC DITPWESKRR CTSPDGKVCS
     NRGTCVCGEC SCHDVDPTGD WGDIHGDTCE CDERDCRAVY DRYSDDFCSG HGQCNCGRCD
     CRAGWYGKKC EHPRNCPLSA EESTKKCQGS SDLPCSGRGR CECGRCTCYP PGDSRVYGKT
     CECDDRRCED LDGVVCGGHG MCSCGRCVCE KGWFGKLCQH LRKCNMTEEQ SRSLCESADG
     TLCSGKGSCH CGKCICSGEE WYISGEFCDC DDRDCDKHDG LICTGNGICS CGNCECWDGW
     NGNACEIWLG TEYP
//
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