ID O10D3_MOUSE Reviewed; 312 AA.
AC Q8VEY3;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 24-JAN-2024, entry version 137.
DE RecName: Full=Olfactory receptor 10D3 {ECO:0000305};
DE AltName: Full=Olfactory receptor 224-9;
DE AltName: Full=Olfactory receptor 958;
GN Name=Or10d3 {ECO:0000312|MGI:MGI:3030792};
GN Synonyms=Mor224-9 {ECO:0000312|MGI:MGI:3030792},
GN Olfr958 {ECO:0000312|MGI:MGI:3030792};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073763; AAL61426.1; -; Genomic_DNA.
DR EMBL; AY318149; AAP71421.1; -; Genomic_DNA.
DR EMBL; BC148230; AAI48231.1; -; mRNA.
DR CCDS; CCDS23050.1; -.
DR RefSeq; NP_666442.1; NM_146330.1.
DR AlphaFoldDB; Q8VEY3; -.
DR SMR; Q8VEY3; -.
DR STRING; 10090.ENSMUSP00000149788; -.
DR GlyCosmos; Q8VEY3; 1 site, No reported glycans.
DR GlyGen; Q8VEY3; 1 site.
DR PaxDb; 10090-ENSMUSP00000049930; -.
DR Antibodypedia; 65551; 7 antibodies from 7 providers.
DR DNASU; 258327; -.
DR Ensembl; ENSMUST00000062545.3; ENSMUSP00000049930.3; ENSMUSG00000050853.4.
DR Ensembl; ENSMUST00000215505.2; ENSMUSP00000149018.2; ENSMUSG00000050853.4.
DR Ensembl; ENSMUST00000217227.2; ENSMUSP00000149788.2; ENSMUSG00000050853.4.
DR GeneID; 258327; -.
DR KEGG; mmu:258327; -.
DR UCSC; uc009oyc.1; mouse.
DR AGR; MGI:3030792; -.
DR CTD; 26497; -.
DR MGI; MGI:3030792; Or10d3.
DR VEuPathDB; HostDB:ENSMUSG00000050853; -.
DR eggNOG; ENOG502SH9P; Eukaryota.
DR GeneTree; ENSGT01050000244869; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8VEY3; -.
DR OMA; FALPYCG; -.
DR OrthoDB; 4307986at2759; -.
DR PhylomeDB; Q8VEY3; -.
DR TreeFam; TF336512; -.
DR BioGRID-ORCS; 258327; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8VEY3; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8VEY3; Protein.
DR Bgee; ENSMUSG00000050853; Expressed in respiratory tract epithelium and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IDA:MGI.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR CDD; cd15228; 7tmA_OR10D-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR26453:SF221; OLFACTORY RECEPTOR 10D3-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 10D3"
FT /id="PRO_0000326026"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..266
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 312 AA; 34528 MW; 22EC6C324427A2E3 CRC64;
MEIKNCSVVT EFILLGIPHT EGFETLLFVL FLPFYACTLV GNVSILVAVI SSTRLHTPMY
FFLGNLSVFD MGFSSVTCPK MLFYLMGLSR LISYQDCVSQ LFFFHFLGSI ECFLYTVMAY
DRFAAICHPL RYSVIMNSKI CVALAVGTWL LGCFHSSVLT SLTFTLPYCG PNEVDHFFCD
IPAILPLASA DTSLAQRVSF TNVGLVSLVC FLLILLSYTR ITISILSIQS TEGRQRAFST
CSAHLIAILC AYGPIITIYL QPTPNPMLGT VVQILMNLVG PMLNPLIYTL RNKEVKIALK
KILHGKGSVS EG
//
