ID O5P70_MOUSE Reviewed; 330 AA.
AC Q8VF12;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 140.
DE RecName: Full=Olfactory receptor 5P70 {ECO:0000305};
DE AltName: Full=Olfactory receptor 204-37;
DE AltName: Full=Olfactory receptor 495;
GN Name=Or5p70 {ECO:0000312|MGI:MGI:3030329};
GN Synonyms=Mor204-37 {ECO:0000312|MGI:MGI:3030329},
GN Olfr495 {ECO:0000312|MGI:MGI:3030329};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073729; AAL61392.1; -; Genomic_DNA.
DR EMBL; AY317603; AAP70998.1; -; Genomic_DNA.
DR CCDS; CCDS21714.1; -.
DR RefSeq; NP_666476.1; NM_146364.1.
DR AlphaFoldDB; Q8VF12; -.
DR SMR; Q8VF12; -.
DR STRING; 10090.ENSMUSP00000150689; -.
DR GlyCosmos; Q8VF12; 1 site, No reported glycans.
DR GlyGen; Q8VF12; 1 site.
DR PaxDb; 10090-ENSMUSP00000071440; -.
DR DNASU; 258361; -.
DR Ensembl; ENSMUST00000210990.2; ENSMUSP00000147501.2; ENSMUSG00000110253.3.
DR Ensembl; ENSMUST00000215215.2; ENSMUSP00000150689.2; ENSMUSG00000110253.3.
DR GeneID; 258361; -.
DR KEGG; mmu:258361; -.
DR UCSC; uc009jcj.1; mouse.
DR AGR; MGI:3030329; -.
DR CTD; 258361; -.
DR MGI; MGI:3030329; Or5p70.
DR VEuPathDB; HostDB:ENSMUSG00000110253; -.
DR eggNOG; ENOG502SKA1; Eukaryota.
DR GeneTree; ENSGT01100000263499; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VF12; -.
DR OMA; CSIQFVS; -.
DR OrthoDB; 4805544at2759; -.
DR PhylomeDB; Q8VF12; -.
DR TreeFam; TF338848; -.
DR BioGRID-ORCS; 258361; 0 hits in 39 CRISPR screens.
DR ChiTaRS; Olfr495; mouse.
DR PRO; PR:Q8VF12; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8VF12; Protein.
DR GO; GO:0016020; C:membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR CDD; cd15416; 7tmA_OR5P-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR48018:SF193; OLFACTORY RECEPTOR 472-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..330
FT /note="Olfactory receptor 5P70"
FT /id="PRO_0000150850"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..330
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 330 AA; 36873 MW; 8E68CDCE67F964B8 CRC64;
MAFLEDGNHT IVTEFILLGL TDDPVLRDIL FTIILCIYLV TVSGNLSTIL LIRVSSQLHH
PMYFFLSHLA SVDIGISSSV TPNMLANFLV KPNTISYIGC SIQFTSAVFL ATVECFLLAA
MAYDRFVAIC NPLLYSTKMS REACIQLVVG SYIQGLLNAS FFTLSFFSLI FCGPNRINHF
YCDLAPLVEL SCSDVTLAVV ITSISAGFIT LTTVFVIAIS YSCIFITIMK MHSTESRYKA
FSTCTSHLTA VTLFYGTTMF IYVMPKSSYS TDQNKVLSVF YMVVIPMLNP LIYSLRNNEI
KGALKRYLGK KIFSYGNLFC KTHYNDTHQV
//
