ID OR5M5_MOUSE Reviewed; 318 AA.
AC Q8VFL5;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 24-JAN-2024, entry version 144.
DE RecName: Full=Olfactory receptor 5M5 {ECO:0000305};
DE AltName: Full=Olfactory receptor 1030;
DE AltName: Full=Olfactory receptor 196-2;
GN Name=Or5m5 {ECO:0000312|MGI:MGI:3030864};
GN Synonyms=Mor196-2 {ECO:0000312|MGI:MGI:3030864},
GN Olfr1030 {ECO:0000312|MGI:MGI:3030864};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP71477.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY073509; AAL61172.1; -; Genomic_DNA.
DR EMBL; AY318225; AAP71477.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS16231.1; -.
DR RefSeq; NP_666799.1; NM_146588.2.
DR AlphaFoldDB; Q8VFL5; -.
DR SMR; Q8VFL5; -.
DR STRING; 10090.ENSMUSP00000053309; -.
DR GlyCosmos; Q8VFL5; 1 site, No reported glycans.
DR GlyGen; Q8VFL5; 1 site.
DR PaxDb; 10090-ENSMUSP00000053309; -.
DR Ensembl; ENSMUST00000056849.3; ENSMUSP00000053309.2; ENSMUSG00000044923.5.
DR GeneID; 258581; -.
DR KEGG; mmu:258581; -.
DR UCSC; uc008klh.2; mouse.
DR AGR; MGI:3030864; -.
DR CTD; 258581; -.
DR MGI; MGI:3030864; Or5m5.
DR VEuPathDB; HostDB:ENSMUSG00000044923; -.
DR eggNOG; ENOG502TC7V; Eukaryota.
DR GeneTree; ENSGT01100000263503; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VFL5; -.
DR OMA; MLAPKKM; -.
DR OrthoDB; 4625095at2759; -.
DR PhylomeDB; Q8VFL5; -.
DR TreeFam; TF352751; -.
DR BioGRID-ORCS; 258581; 2 hits in 70 CRISPR screens.
DR PRO; PR:Q8VFL5; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8VFL5; Protein.
DR ExpressionAtlas; Q8VFL5; baseline and differential.
DR GO; GO:0016020; C:membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR CDD; cd15412; 7tmA_OR5M-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR48018:SF166; OLFACTORY RECEPTOR 1030; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Olfactory receptor 5M5"
FT /id="PRO_0000150862"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 103..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 318 AA; 36382 MW; 7DFFF1B58DBCAB43 CRC64;
MLAPKKMVRG NYSMVTEFIL LGLTDRPELQ PLLFVLFLVI YLITVGGNLG MMVLIRIDSR
LHTPMYYFLA SLSCLDLCYS TNVTPKMLVN FLSEKKTISY AACLVQCYFF IAMVITEYYM
LAVMAYDRYM AICNPLLYSS KMSKGVCVRL IAGPYIYGFL SGLMETMWTY RLTFCGSNII
NHFYCADPPL IRLSCSDTFI KETSMFVVAG FNLSNSLFII LISYLFILIA ILRMRSAEGR
RKAFSTCGSH LVAVTVFYGT LFCMYVRPPT DKSVEQSKII AVFYTFVSPM LNPIIYSLRN
KDVKHAFWKL VRRNVLSK
//
