ID ASB17_MOUSE Reviewed; 295 AA.
AC Q8VHP9; Q9CUF9;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE RecName: Full=Ankyrin repeat and SOCS box protein 17;
DE Short=ASB-17;
GN Name=Asb17;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Kile B.T., Hilton D.J., Nicola N.A.;
RT "SOCS box proteins.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-172.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15204681; DOI=10.1080/01485010490425485;
RA Guo J.H., Saiyin H., Wei Y.H., Chen S., Chen L., Bi G., Ma L.J., Zhou G.J.,
RA Huang C.Q., Yu L., Dai L.;
RT "Expression of testis specific ankyrin repeat and SOCS box-containing 17
RT gene.";
RL Arch. Androl. 50:155-161(2004).
RN [5]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15460110; DOI=10.1017/s0967199404002722;
RA Kim K.S., Kim M.S., Kim S.K., Baek K.H.;
RT "Murine Asb-17 expression during mouse testis development and
RT spermatogenesis.";
RL Zygote 12:151-156(2004).
CC -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- TISSUE SPECIFICITY: Specifically expressed in testis (PubMed:15460110).
CC Localizes to spermatogenic cells in testis, with highest expression in
CC round spermatids and condensing spermatids and lower expression in
CC pachytene spermatocytes (PubMed:15204681, PubMed:15460110).
CC {ECO:0000269|PubMed:15204681, ECO:0000269|PubMed:15460110}.
CC -!- DEVELOPMENTAL STAGE: Expressed in testis from 3 weeks of age onwards,
CC reaching maximum levels by 4 to 5 weeks of age.
CC {ECO:0000269|PubMed:15204681, ECO:0000269|PubMed:15460110}.
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000305}.
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DR EMBL; AF425641; AAL60518.1; -; mRNA.
DR EMBL; BC049572; AAH49572.1; -; mRNA.
DR EMBL; AK016273; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS17922.1; -.
DR RefSeq; NP_080034.2; NM_025758.4.
DR AlphaFoldDB; Q8VHP9; -.
DR STRING; 10090.ENSMUSP00000041293; -.
DR PhosphoSitePlus; Q8VHP9; -.
DR PaxDb; 10090-ENSMUSP00000041293; -.
DR ProteomicsDB; 277247; -.
DR Antibodypedia; 46911; 159 antibodies from 23 providers.
DR Ensembl; ENSMUST00000044089.4; ENSMUSP00000041293.4; ENSMUSG00000038997.5.
DR GeneID; 66772; -.
DR KEGG; mmu:66772; -.
DR UCSC; uc008rty.1; mouse.
DR AGR; MGI:1914022; -.
DR CTD; 127247; -.
DR MGI; MGI:1914022; Asb17.
DR VEuPathDB; HostDB:ENSMUSG00000038997; -.
DR eggNOG; ENOG502QVW2; Eukaryota.
DR GeneTree; ENSGT00390000018077; -.
DR HOGENOM; CLU_082443_0_0_1; -.
DR InParanoid; Q8VHP9; -.
DR OMA; KLCHKTS; -.
DR OrthoDB; 3960855at2759; -.
DR PhylomeDB; Q8VHP9; -.
DR TreeFam; TF337448; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 66772; 1 hit in 77 CRISPR screens.
DR PRO; PR:Q8VHP9; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8VHP9; Protein.
DR Bgee; ENSMUSG00000038997; Expressed in seminiferous tubule of testis and 27 other cell types or tissues.
DR ExpressionAtlas; Q8VHP9; baseline and differential.
DR Genevisible; Q8VHP9; MM.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03716; SOCS_ASB_like; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039147; ASB17.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR20966; ANKYRIN REPEAT AND SOCS BOX PROTEIN 17; 1.
DR PANTHER; PTHR20966:SF2; ANKYRIN REPEAT AND SOCS BOX PROTEIN 17; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..295
FT /note="Ankyrin repeat and SOCS box protein 17"
FT /id="PRO_0000066961"
FT REPEAT 146..176
FT /note="ANK"
FT DOMAIN 243..295
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
SQ SEQUENCE 295 AA; 34471 MW; 6FC0A4C55E4181AE CRC64;
MNNSSKLCRK TSFPRSNIFC NLVDKIVKRP SLQFLGQWGY HCYEPRIYRT LAKILRYVDL
DGFDILLTDY IAFVEKSGHR FELNFNLEFT EICVNTILYW VFARKGNPDF VELLLKKTKD
YVQDRSCSLA LIWRTFTPVY CPSPLSGITP LLYVAQTRQS NILKILLQYG ILEREKNPIN
IVLTILLYPS RVRIMVDHEL IDIQEDAKTC LMLCSRVLST ISVREIETQL SLGRRPIIQN
WLDYIPPTRY KDPCELVHLC RITIRTQLLA NNMLPNGIFS LLIPTRLQNF LNLES
//
