GenomeNet

Database: UniProt
Entry: Q8VVL0
LinkDB: Q8VVL0
Original site: Q8VVL0 
ID   KITH_MYCMS              Reviewed;         209 AA.
AC   Q8VVL0;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-DEC-2018, entry version 89.
DE   RecName: Full=Thymidine kinase {ECO:0000255|HAMAP-Rule:MF_00124};
DE            EC=2.7.1.21 {ECO:0000255|HAMAP-Rule:MF_00124};
GN   Name=tdk {ECO:0000255|HAMAP-Rule:MF_00124};
GN   OrderedLocusNames=MSC_0149;
OS   Mycoplasma mycoides subsp. mycoides SC (strain PG1).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PG1;
RA   Carnrot C., Eriksson S., Wang L.;
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PG1;
RX   PubMed=14762060; DOI=10.1101/gr.1673304;
RA   Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J.,
RA   Johansson K.-E., Pettersson B., Uhlen M.;
RT   "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type
RT   strain PG1T, the causative agent of contagious bovine pleuropneumonia
RT   (CBPP).";
RL   Genome Res. 14:221-227(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + thymidine = ADP + dTMP + H(+);
CC         Xref=Rhea:RHEA:19129, ChEBI:CHEBI:15378, ChEBI:CHEBI:17748,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216;
CC         EC=2.7.1.21; Evidence={ECO:0000255|HAMAP-Rule:MF_00124};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00124}.
DR   EMBL; AJ313087; CAC85214.1; -; Genomic_DNA.
DR   EMBL; BX293980; CAE76794.1; -; Genomic_DNA.
DR   RefSeq; NP_975152.1; NC_005364.2.
DR   RefSeq; WP_011166351.1; NC_005364.2.
DR   ProteinModelPortal; Q8VVL0; -.
DR   SMR; Q8VVL0; -.
DR   STRING; 272632.MSC_0149; -.
DR   EnsemblBacteria; CAE76794; CAE76794; MSC_0149.
DR   GeneID; 2744372; -.
DR   KEGG; mmy:MSC_0149; -.
DR   PATRIC; fig|272632.4.peg.158; -.
DR   eggNOG; ENOG4107T8J; Bacteria.
DR   eggNOG; COG1435; LUCA.
DR   HOGENOM; HOG000076390; -.
DR   KO; K00857; -.
DR   OMA; KEQFGWI; -.
DR   BioCyc; MMYC272632:G1G3L-163-MONOMER; -.
DR   Proteomes; UP000001016; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00124; Thymidine_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA synthesis; Kinase;
KW   Metal-binding; Nucleotide-binding; Reference proteome; Transferase;
KW   Zinc.
FT   CHAIN         1    209       Thymidine kinase.
FT                                /FTId=PRO_0000174997.
FT   NP_BIND      25     32       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   NP_BIND     103    106       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   ACT_SITE    104    104       Proton acceptor. {ECO:0000255|HAMAP-
FT                                Rule:MF_00124}.
FT   METAL       160    160       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   METAL       163    163       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   METAL       198    198       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   METAL       201    201       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
SQ   SEQUENCE   209 AA;  23943 MW;  081C94637451C2E2 CRC64;
     MTELDINEIE AYNSNKMGWI ELITGCMFAG KTEEFIRRLR VLSYAKKRVL AFKPSIDNRY
     SVENIISHSG SKLDSYLVHS SDEIKQIIEK ENQIQQVDVI GIDEVQFFDE QVVELIEQLA
     NQGIIVIVNG LDKDFRCLPF KNVDKLLVTA EFVTKLRARC HLCGNFANRS QKIVNGQPAL
     WDSPLILVDG KESYEARCRN CFIVPKKEV
//
DBGET integrated database retrieval system