GenomeNet

Database: UniProt
Entry: Q8W103
LinkDB: Q8W103
Original site: Q8W103 
ID   CHR24_ARATH             Reviewed;        1090 AA.
AC   Q8W103; Q9LVN8;
DT   29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   16-OCT-2019, entry version 115.
DE   RecName: Full=Protein CHROMATIN REMODELING 24 {ECO:0000303|PubMed:16547115};
DE            Short=AtCHR24;
DE            EC=3.6.4.-;
DE   AltName: Full=DNA excision repair protein CHR24 {ECO:0000250|UniProtKB:Q2NKX8};
GN   Name=CHR24 {ECO:0000303|PubMed:16547115};
GN   OrderedLocusNames=At5g63950 {ECO:0000312|Araport:AT5G63950};
GN   ORFNames=MBM17.5 {ECO:0000312|EMBL:BAA96898.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:AAL58917.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT   features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:31-63(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana
RT   reference genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA   Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA   Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA   Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA   Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA   Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA   Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA   Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA   Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA   Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA   Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA   Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16547115; DOI=10.1534/genetics.105.051664;
RA   Shaked H., Avivi-Ragolsky N., Levy A.A.;
RT   "Involvement of the Arabidopsis SWI2/SNF2 chromatin remodeling gene
RT   family in DNA damage response and recombination.";
RL   Genetics 173:985-994(2006).
RN   [5]
RP   FUNCTION.
RX   PubMed=21968679; DOI=10.4238/vol10-3gmr1347;
RA   Johnson R.A., Hellens R.P., Love D.R.;
RT   "A transient assay for recombination demonstrates that Arabidopsis
RT   SNM1 and XRCC3 enhance non-homologous recombination.";
RL   Genet. Mol. Res. 10:2104-2132(2011).
RN   [6]
RP   GENE FAMILY.
RX   PubMed=24265739; DOI=10.1371/journal.pone.0078982;
RA   Xu R., Zhang S., Huang J., Zheng C.;
RT   "Genome-wide comparative in silico analysis of the RNA helicase gene
RT   family in Zea mays and Glycine max: a comparison with Arabidopsis and
RT   Oryza sativa.";
RL   PLoS ONE 8:E78982-E78982(2013).
CC   -!- FUNCTION: DNA helicase that acts as an essential component of the
CC       spindle assembly checkpoint (By similarity). Probable chromatin
CC       remodeling factor that regulate homologous recombination (HR) and
CC       non-homologous recombination (NHR). {ECO:0000250|UniProtKB:Q2NKX8,
CC       ECO:0000269|PubMed:21968679, ECO:0000303|PubMed:16547115}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
CC       ProRule:PRU00768}.
CC   -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA96898.1; Type=Erroneous gene model prediction;
DR   EMBL; AB019227; BAA96898.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED97819.1; -; Genomic_DNA.
DR   EMBL; AF462829; AAL58917.1; -; mRNA.
DR   EMBL; AY142010; AAM98274.1; -; mRNA.
DR   RefSeq; NP_201200.2; NM_125791.3.
DR   SMR; Q8W103; -.
DR   STRING; 3702.AT5G63950.1; -.
DR   iPTMnet; Q8W103; -.
DR   PaxDb; Q8W103; -.
DR   PRIDE; Q8W103; -.
DR   EnsemblPlants; AT5G63950.1; AT5G63950.1; AT5G63950.
DR   GeneID; 836516; -.
DR   Gramene; AT5G63950.1; AT5G63950.1; AT5G63950.
DR   KEGG; ath:AT5G63950; -.
DR   Araport; AT5G63950; -.
DR   TAIR; locus:2160811; AT5G63950.
DR   eggNOG; KOG0387; Eukaryota.
DR   eggNOG; ENOG410XP4Z; LUCA.
DR   HOGENOM; HOG000029838; -.
DR   InParanoid; Q8W103; -.
DR   KO; K20093; -.
DR   OrthoDB; 372069at2759; -.
DR   PhylomeDB; Q8W103; -.
DR   PRO; PR:Q8W103; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q8W103; baseline and differential.
DR   Genevisible; Q8W103; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015616; F:DNA translocase activity; IBA:GO_Central.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0045951; P:positive regulation of mitotic recombination; IDA:UniProtKB.
DR   GO; GO:0046686; P:response to cadmium ion; IEP:TAIR.
DR   Gene3D; 3.40.50.10810; -; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00176; SNF2_N; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Coiled coil; Complete proteome; DNA recombination;
KW   DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN         1   1090       Protein CHROMATIN REMODELING 24.
FT                                /FTId=PRO_0000430858.
FT   DOMAIN      389    564       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      736    895       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     402    409       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   COILED     1043   1069       {ECO:0000255}.
FT   MOTIF        44     51       Nuclear localization signal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00768}.
FT   MOTIF       515    518       DEAH box. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   COMPBIAS    310    319       Poly-Asp. {ECO:0000255}.
SQ   SEQUENCE   1090 AA;  122803 MW;  6E3CA54E6B1DCAE2 CRC64;
     MAENTASHRR KPRSLNDRHY SILQDLSAPP RQPPSSSHGE DEETKKSMIK LAGRRRLCKA
     LPKEDEADGY DDPDLVDFYS PVKGETSLDS AGIGNKFTSW DESKEANTEL AGEPNFSIIT
     DFCSPSPQLK QKEEMQGDGG RNEIMGILDD LTSKLGTMSI QKKKDSQSND FDACGVKSQV
     DKFDFEDAKS SFSLLSDLSK SSPDVVTTYN AGVNSIKDKQ GKSGFAIREE QTSKEFSREW
     EERISNVGKQ NSYSGRHFDD NSEDNRQGYN LDRGKSQCKE VDQSMKTTRH IEVSEKIRTV
     GRSNAAKLRD LDEDDDDDDC LILSGKKAAE MKINKPARSY NAKRHGYDER SLEDEGSITL
     TGLNLSYTLP GKIATMLYPH QREGLNWLWS LHTQGKGGIL GDDMGLGKTM QICSFLAGLF
     HSKLIKRALV VAPKTLLPHW MKELATVGLS QMTREYYGTS TKAREYDLHH ILQGKGILLT
     TYDIVRNNTK ALQGDDHYTD EDDEDGNKWD YMILDEGHLI KNPNTQRAKS LLEIPSSHRI
     IISGTPIQNN LKELWALFNF SCPGLLGDKN WFKQNYEHYI LRGTDKNATD REQRIGSTVA
     KNLREHIQPF FLRRLKSEVF GDDGATSKLS KKDEIVVWLR LTACQRQLYE AFLNSEIVLS
     AFDGSPLAAL TILKKICDHP LLLTKRAAED VLEGMDSTLT QEEAGVAERL AMHIADNVDT
     DDFQTKNDSI SCKLSFIMSL LENLIPEGHR VLIFSQTRKM LNLIQDSLTS NGYSFLRIDG
     TTKAPDRLKT VEEFQEGHVA PIFLLTSQVG GLGLTLTKAD RVIVVDPAWN PSTDNQSVDR
     AYRIGQTKDV IVYRLMTSAT VEEKIYRKQV YKGGLFKTAT EHKEQIRYFS QQDLRELFSL
     PKGGFDVSPT QQQLYEEHYN QIKLDEKLES HVKFLETLGI AGVSHHSLLF SKTAPIQAIQ
     KDEEEQIRRE TALLLGRASA SISQDTVING ADYAFKPKDV NLDKRINISP VDDKELSESV
     IKARLNRLTM LLQNKGTVSR LPDGGAKIQK QIAELTRELK DMKAAERINM PQVIDLEEDI
     SRKMQKGLNL
//
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