GenomeNet

Database: UniProt
Entry: Q8WTR8
LinkDB: Q8WTR8
Original site: Q8WTR8 
ID   NET5_HUMAN              Reviewed;         489 AA.
AC   Q8WTR8; Q8N4X9; Q8WU63;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 2.
DT   16-JAN-2019, entry version 130.
DE   RecName: Full=Netrin-5;
DE   AltName: Full=Netrin-1-like protein;
DE   Flags: Precursor;
GN   Name=NTN5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a role in neurogenesis. Prevents motor neuron cell
CC       body migration out of the neural tube.
CC       {ECO:0000250|UniProtKB:Q3UQ22}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8WTR8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8WTR8-2; Sequence=VSP_031667, VSP_031668;
DR   EMBL; CH471177; EAW52386.1; -; Genomic_DNA.
DR   EMBL; CH471177; EAW52387.1; -; Genomic_DNA.
DR   EMBL; BC018654; AAH18654.2; -; mRNA.
DR   EMBL; BC018697; AAH18697.2; -; mRNA.
DR   EMBL; BC021210; AAH21210.2; -; mRNA.
DR   EMBL; BC033207; AAH33207.1; -; mRNA.
DR   CCDS; CCDS33068.1; -. [Q8WTR8-1]
DR   RefSeq; NP_665806.1; NM_145807.2. [Q8WTR8-1]
DR   UniGene; Hs.326217; -.
DR   ProteinModelPortal; Q8WTR8; -.
DR   SMR; Q8WTR8; -.
DR   STRING; 9606.ENSP00000270235; -.
DR   PhosphoSitePlus; Q8WTR8; -.
DR   BioMuta; NTN5; -.
DR   DMDM; 74730628; -.
DR   PaxDb; Q8WTR8; -.
DR   PRIDE; Q8WTR8; -.
DR   ProteomicsDB; 74592; -.
DR   ProteomicsDB; 74593; -. [Q8WTR8-2]
DR   Ensembl; ENST00000270235; ENSP00000270235; ENSG00000142233. [Q8WTR8-1]
DR   GeneID; 126147; -.
DR   KEGG; hsa:126147; -.
DR   UCSC; uc002pkb.3; human. [Q8WTR8-1]
DR   CTD; 126147; -.
DR   EuPathDB; HostDB:ENSG00000142233.11; -.
DR   GeneCards; NTN5; -.
DR   HGNC; HGNC:25208; NTN5.
DR   neXtProt; NX_Q8WTR8; -.
DR   OpenTargets; ENSG00000142233; -.
DR   PharmGKB; PA164724232; -.
DR   eggNOG; KOG3512; Eukaryota.
DR   eggNOG; ENOG410XS7U; LUCA.
DR   GeneTree; ENSGT00940000161874; -.
DR   HOGENOM; HOG000286017; -.
DR   HOVERGEN; HBG096704; -.
DR   InParanoid; Q8WTR8; -.
DR   OMA; CGCLRLQ; -.
DR   OrthoDB; 858946at2759; -.
DR   PhylomeDB; Q8WTR8; -.
DR   TreeFam; TF352481; -.
DR   GenomeRNAi; 126147; -.
DR   PRO; PR:Q8WTR8; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000142233; Expressed in 89 organ(s), highest expression level in right uterine tube.
DR   ExpressionAtlas; Q8WTR8; baseline and differential.
DR   Genevisible; Q8WTR8; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0022008; P:neurogenesis; ISS:UniProtKB.
DR   InterPro; IPR002049; Laminin_EGF.
DR   InterPro; IPR001134; Netrin_domain.
DR   InterPro; IPR018933; Netrin_module_non-TIMP.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   Pfam; PF00053; Laminin_EGF; 3.
DR   Pfam; PF01759; NTR; 1.
DR   SMART; SM00643; C345C; 1.
DR   SMART; SM00180; EGF_Lam; 3.
DR   SUPFAM; SSF50242; SSF50242; 1.
DR   PROSITE; PS00022; EGF_1; 2.
DR   PROSITE; PS01248; EGF_LAM_1; 2.
DR   PROSITE; PS50027; EGF_LAM_2; 3.
DR   PROSITE; PS50189; NTR; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Developmental protein;
KW   Disulfide bond; Glycoprotein; Laminin EGF-like domain; Neurogenesis;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL        1     16       {ECO:0000255}.
FT   CHAIN        17    489       Netrin-5.
FT                                /FTId=PRO_0000320575.
FT   DOMAIN      157    211       Laminin EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00460}.
FT   DOMAIN      212    274       Laminin EGF-like 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00460}.
FT   DOMAIN      275    324       Laminin EGF-like 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00460}.
FT   DOMAIN      345    475       NTR. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00295}.
FT   CARBOHYD     62     62       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    157    166       {ECO:0000250}.
FT   DISULFID    159    175       {ECO:0000250}.
FT   DISULFID    177    186       {ECO:0000250}.
FT   DISULFID    189    209       {ECO:0000250}.
FT   DISULFID    212    221       {ECO:0000250}.
FT   DISULFID    214    239       {ECO:0000250}.
FT   DISULFID    242    251       {ECO:0000250}.
FT   DISULFID    254    272       {ECO:0000250}.
FT   DISULFID    275    287       {ECO:0000250}.
FT   DISULFID    277    294       {ECO:0000250}.
FT   DISULFID    296    305       {ECO:0000250}.
FT   DISULFID    308    322       {ECO:0000250}.
FT   DISULFID    345    418       {ECO:0000250}.
FT   DISULFID    349    420       {ECO:0000250}.
FT   DISULFID    364    475       {ECO:0000250}.
FT   VAR_SEQ     342    350       DPQCQNYCN -> GKTVWHGGP (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_031667.
FT   VAR_SEQ     351    489       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_031668.
SQ   SEQUENCE   489 AA;  53174 MW;  3438D41FA45F8B3E CRC64;
     MPVTFALLLL LGQATADPCY DPQGRPQFCL PPVTQLAAVA ASCPQACALS PGNHLGARET
     CNGSLTLALG GPFLLTSVSL RFCTPGPPAL ILSAAWASGG PWRLLWHRPA WPGALGGPER
     VTFHSTPGPK ATVAASHLRV EFGGQAGLAA AGLRGRCQCH GHAARCAARA RPPRCHCRHH
     TTGPGCESCR PSHRDWPWRP ATPRHPHPCL PCSCNQHARR CRFNSELFRL SGGRSGGVCE
     RCRHHTAGRH CHYCQPGFWR DPSQPIFSRR ACRACQCHPI GATGGTCNQT SGQCTCKLGV
     TGLTCNRCGP GYQQSRSPRM PCQRIPEATT TLATTPGAYS SDPQCQNYCN MSDTRVHMSL
     RRYCQQDHVL RAQVLASEAA GPAWQRLAVR VLAVYKQRAQ PVRRGDQDAW VPRADLTCGC
     LRLQPGTDYL LLGSAVGDPD PTRLILDRHG LALPWRPRWA RPLKRLQQEE RAGGCRGVRA
     PTPSPRPEH
//
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