ID MUC16_HUMAN Reviewed; 14507 AA.
AC Q8WXI7; B5ME49; Q6ZQW5; Q96RK2;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-MAY-2016, sequence version 3.
DT 27-MAR-2024, entry version 154.
DE RecName: Full=Mucin-16 {ECO:0000305};
DE Short=MUC-16;
DE AltName: Full=Ovarian cancer-related tumor marker CA125 {ECO:0000303|PubMed:12218296};
DE Short=CA-125 {ECO:0000303|PubMed:12218296};
DE AltName: Full=Ovarian carcinoma antigen CA125 {ECO:0000303|PubMed:11369781};
GN Name=MUC16 {ECO:0000312|HGNC:HGNC:15582};
GN Synonyms=CA125 {ECO:0000303|PubMed:11786729};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-10429, SEQUENCE REVISION TO N-TERMINUS,
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=12218296; DOI=10.1159/000064032;
RA O'Brien T.J., Beard J.B., Underwood L.J., Shigemasa K.;
RT "The CA 125 gene: a newly discovered extension of the glycosylated N-
RT terminal domain doubles the size of this extracellular superstructure.";
RL Tumor Biol. 23:154-169(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 10430-14507, REGION, AND POLYMORPHISM.
RX PubMed=11786729; DOI=10.1159/000050638;
RA O'Brien T.J., Beard J.B., Underwood L.J., Dennis R.A., Santin A.D.,
RA York L.;
RT "The CA 125 gene: an extracellular superstructure dominated by repeat
RT sequences.";
RL Tumor Biol. 22:348-366(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 8295-14507, PROTEIN SEQUENCE OF 13715-13720
RP AND 14338-14350, AND TISSUE SPECIFICITY.
RX PubMed=11369781; DOI=10.1074/jbc.m103554200;
RA Yin B.W.T., Lloyd K.O.;
RT "Molecular cloning of the CA125 ovarian cancer antigen: identification as a
RT new mucin, MUC16.";
RL J. Biol. Chem. 276:27371-27375(2001).
RN [5]
RP SEQUENCE REVISION.
RA Lloyd K.O., Yin B.W.T.;
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12828-14050.
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [7]
RP PHOSPHORYLATION.
RX PubMed=9276028; DOI=10.1159/000218041;
RA Fendrick J.L., Konishi I., Geary S.M., Parmley T.H., Quirk J.G. Jr.,
RA O'Brien T.J.;
RT "CA125 phosphorylation is associated with its secretion from the WISH human
RT amnion cell line.";
RL Tumor Biol. 18:278-289(1997).
RN [8]
RP GLYCOSYLATION.
RX PubMed=12734200; DOI=10.1074/jbc.m302741200;
RA Kui Wong N., Easton R.L., Panico M., Sutton-Smith M., Morrison J.C.,
RA Lattanzio F.A., Morris H.R., Clark G.F., Dell A., Patankar M.S.;
RT "Characterization of the oligosaccharides associated with the human ovarian
RT tumor marker CA125.";
RL J. Biol. Chem. 278:28619-28634(2003).
RN [9]
RP INTERACTION WITH MSLN.
RX PubMed=14676194; DOI=10.1074/jbc.m312372200;
RA Rump A., Morikawa Y., Tanaka M., Minami S., Umesaki N., Takeuchi M.,
RA Miyajima A.;
RT "Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell
RT adhesion.";
RL J. Biol. Chem. 279:9190-9198(2004).
RN [10]
RP REVIEW, AND POLYMORPHISM.
RX PubMed=15788735; DOI=10.1177/1099800404274445;
RA McLemore M.R., Aouizerat B.;
RT "Introducing the MUC16 gene: implications for prevention and early
RT detection in epithelial ovarian cancer.";
RL Biol. Res. Nurs. 6:262-267(2005).
RN [11]
RP TISSUE SPECIFICITY.
RX PubMed=16384952; DOI=10.1167/iovs.05-0735;
RA Argueso P., Tisdale A., Spurr-Michaud S., Sumiyoshi M., Gipson I.K.;
RT "Mucin characteristics of human corneal-limbal epithelial cells that
RT exclude the rose bengal anionic dye.";
RL Invest. Ophthalmol. Vis. Sci. 47:113-119(2006).
CC -!- FUNCTION: Thought to provide a protective, lubricating barrier against
CC particles and infectious agents at mucosal surfaces. {ECO:0000250}.
CC -!- SUBUNIT: Binds to MSLN. Binding to MSLN mediates heterotypic cell
CC adhesion. This may contribute to the metastasis of ovarian cancer to
CC the peritoneum by initiating cell attachment to the mesothelial
CC epithelium via binding to MSLN.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein. Secreted, extracellular space. Note=May be liberated into the
CC extracellular space following the phosphorylation of the intracellular
CC C-terminus which induces the proteolytic cleavage and liberation of the
CC extracellular domain.
CC -!- TISSUE SPECIFICITY: Expressed in corneal and conjunctival epithelia (at
CC protein level). Overexpressed in ovarian carcinomas and ovarian low
CC malignant potential (LMP) tumors as compared to the expression in
CC normal ovarian tissue and ovarian adenomas.
CC {ECO:0000269|PubMed:11369781, ECO:0000269|PubMed:12218296,
CC ECO:0000269|PubMed:16384952}.
CC -!- INDUCTION: Up-regulated in ovarian cancer cells.
CC {ECO:0000269|PubMed:12218296}.
CC -!- DOMAIN: Composed of three domains, a Ser-, Thr-rich N-terminal domain,
CC a repeated domain containing between 12 and 60 partially conserved
CC tandem repeats of 156 amino acids and a C-terminal transmembrane
CC contain domain with a short cytoplasmic tail.
CC {ECO:0000269|PubMed:11786729}.
CC -!- PTM: Heavily O-glycosylated; expresses both type 1 and type 2 core
CC glycans. {ECO:0000269|PubMed:12734200}.
CC -!- PTM: Heavily N-glycosylated; expresses primarily high mannose and
CC complex bisecting type N-linked glycans. {ECO:0000269|PubMed:12734200}.
CC -!- PTM: May be phosphorylated. Phosphorylation of the intracellular C-
CC terminal domain may induce proteolytic cleavage and the liberation of
CC the extracellular domain into the extracellular space.
CC {ECO:0000269|PubMed:9276028}.
CC -!- PTM: May contain numerous disulfide bridges. Association of several
CC molecules of the secreted form may occur through interchain disulfide
CC bridges providing an extraordinarily large gel-like matrix in the
CC extracellular space or in the lumen of secretory ducts.
CC -!- POLYMORPHISM: The number of repeats is highly polymorphic and can be
CC composed between 12 and 60 extracellular mucin repeats.
CC {ECO:0000305|PubMed:11786729}.
CC -!- MISCELLANEOUS: Antigen that is the basis for a widely used serum assay
CC for the monitoring of patients with ovarian epithelial cancer. Due to
CC lack of sensitivity for stage I disease and lack of specificity, it is
CC of little value in the detection of early ovarian cancer. Due to its
CC similarly elevated levels in some nonmalignant conditions, it is not
CC specific enough to be used for population screening.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL65133.2; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC87568.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="https://atlasgeneticsoncology.org/gene/41455/MUC16";
CC -!- WEB RESOURCE: Name=Mucin database;
CC URL="http://www.medkem.gu.se/mucinbiology/databases/";
CC ---------------------------------------------------------------------------
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DR EMBL; AC008734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF456494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC016584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF414442; AAL65133.2; ALT_FRAME; mRNA.
DR EMBL; AF361486; AAK74120.3; -; mRNA.
DR EMBL; AK128681; BAC87568.1; ALT_INIT; mRNA.
DR CCDS; CCDS54212.1; -.
DR RefSeq; NP_078966.2; NM_024690.2.
DR PDB; 7SA9; X-ray; 1.69 A; A/B=12665-12857.
DR PDBsum; 7SA9; -.
DR SMR; Q8WXI7; -.
DR BioGRID; 125094; 27.
DR IntAct; Q8WXI7; 2.
DR STRING; 9606.ENSP00000381008; -.
DR ChEMBL; CHEMBL3580482; -.
DR DrugBank; DB01093; Dimethyl sulfoxide.
DR DrugBank; DB04964; Oregovomab.
DR GlyCosmos; Q8WXI7; 103 sites, 1 glycan.
DR GlyGen; Q8WXI7; 207 sites, 2 O-linked glycans (105 sites).
DR iPTMnet; Q8WXI7; -.
DR PhosphoSitePlus; Q8WXI7; -.
DR SwissPalm; Q8WXI7; -.
DR BioMuta; MUC16; -.
DR CPTAC; CPTAC-2227; -.
DR EPD; Q8WXI7; -.
DR jPOST; Q8WXI7; -.
DR MassIVE; Q8WXI7; -.
DR MaxQB; Q8WXI7; -.
DR PaxDb; 9606-ENSP00000381008; -.
DR PeptideAtlas; Q8WXI7; -.
DR ProteomicsDB; 6210; -.
DR ProteomicsDB; 75068; -.
DR Pumba; Q8WXI7; -.
DR ABCD; Q8WXI7; 12 sequenced antibodies.
DR Antibodypedia; 3492; 1294 antibodies from 39 providers.
DR CPTC; Q8WXI7; 3 antibodies.
DR DNASU; 94025; -.
DR Ensembl; ENST00000397910.8; ENSP00000381008.2; ENSG00000181143.16.
DR GeneID; 94025; -.
DR KEGG; hsa:94025; -.
DR UCSC; uc002mkp.3; human.
DR AGR; HGNC:15582; -.
DR CTD; 94025; -.
DR DisGeNET; 94025; -.
DR GeneCards; MUC16; -.
DR HGNC; HGNC:15582; MUC16.
DR HPA; ENSG00000181143; Group enriched (adipose tissue, cervix, fallopian tube, salivary gland).
DR MalaCards; MUC16; -.
DR MIM; 606154; gene.
DR neXtProt; NX_Q8WXI7; -.
DR OpenTargets; ENSG00000181143; -.
DR PharmGKB; PA31314; -.
DR VEuPathDB; HostDB:ENSG00000181143; -.
DR eggNOG; ENOG502RD3J; Eukaryota.
DR GeneTree; ENSGT00440000039287; -.
DR InParanoid; Q8WXI7; -.
DR OMA; FAKPQDK; -.
DR OrthoDB; 5324787at2759; -.
DR PhylomeDB; Q8WXI7; -.
DR TreeFam; TF335600; -.
DR PathwayCommons; Q8WXI7; -.
DR Reactome; R-HSA-5083625; Defective GALNT3 causes HFTC.
DR Reactome; R-HSA-5083632; Defective C1GALT1C1 causes TNPS.
DR Reactome; R-HSA-5083636; Defective GALNT12 causes CRCS1.
DR Reactome; R-HSA-5621480; Dectin-2 family.
DR Reactome; R-HSA-913709; O-linked glycosylation of mucins.
DR Reactome; R-HSA-977068; Termination of O-glycan biosynthesis.
DR SignaLink; Q8WXI7; -.
DR BioGRID-ORCS; 94025; 10 hits in 1147 CRISPR screens.
DR ChiTaRS; MUC16; human.
DR GeneWiki; CA-125; -.
DR GenomeRNAi; 94025; -.
DR Pharos; Q8WXI7; Tbio.
DR PRO; PR:Q8WXI7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8WXI7; Protein.
DR Bgee; ENSG00000181143; Expressed in nasal cavity epithelium and 79 other cell types or tissues.
DR ExpressionAtlas; Q8WXI7; baseline and differential.
DR Genevisible; B5ME49; HS.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:UniProtKB.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005796; C:Golgi lumen; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0031982; C:vesicle; HDA:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; NAS:UniProtKB.
DR Gene3D; 3.30.70.960; SEA domain; 16.
DR InterPro; IPR028850; MUC16.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR14672; MUCIN-16; 1.
DR PANTHER; PTHR14672:SF1; MUCIN-16; 1.
DR Pfam; PF01390; SEA; 16.
DR SMART; SM00200; SEA; 7.
DR SUPFAM; SSF82671; SEA domain; 16.
DR PROSITE; PS50024; SEA; 16.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Direct protein sequencing; Disulfide bond;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW Secreted; Transmembrane; Transmembrane helix.
FT CHAIN 1..14507
FT /note="Mucin-16"
FT /id="PRO_0000436078"
FT TOPO_DOM 1..14451
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 14452..14472
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 14473..14507
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REPEAT 12067..12223
FT /note="1"
FT /evidence="ECO:0000269|PubMed:11786729"
FT DOMAIN 12072..12193
FT /note="SEA 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT REPEAT 12224..12381
FT /note="2"
FT /evidence="ECO:0000269|PubMed:11786729"
FT DOMAIN 12228..12349
FT /note="SEA 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT REPEAT 12382..12537
FT /note="3"
FT /evidence="ECO:0000269|PubMed:11786729"
FT DOMAIN 12386..12507
FT /note="SEA 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT REPEAT 12538..12692
FT /note="4"
FT /evidence="ECO:0000269|PubMed:11786729"
FT DOMAIN 12542..12663
FT /note="SEA 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT REPEAT 12693..12848
FT /note="5"
FT /evidence="ECO:0000269|PubMed:11786729"
FT DOMAIN 12697..12818
FT /note="SEA 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT REPEAT 12849..13004
FT /note="6"
FT /evidence="ECO:0000269|PubMed:11786729"
FT DOMAIN 12853..12974
FT /note="SEA 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT REPEAT 13005..13160
FT /note="7"
FT /evidence="ECO:0000269|PubMed:11786729"
FT DOMAIN 13009..13130
FT /note="SEA 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT REPEAT 13161..13316
FT /note="8"
FT /evidence="ECO:0000269|PubMed:11786729"
FT DOMAIN 13165..13286
FT /note="SEA 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT REPEAT 13317..13472
FT /note="9"
FT /evidence="ECO:0000269|PubMed:11786729"
FT DOMAIN 13321..13442
FT /note="SEA 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT REPEAT 13473..13628
FT /note="10"
FT /evidence="ECO:0000269|PubMed:11786729"
FT DOMAIN 13477..13598
FT /note="SEA 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT REPEAT 13629..13784
FT /note="11"
FT /evidence="ECO:0000269|PubMed:11786729"
FT DOMAIN 13633..13754
FT /note="SEA 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT REPEAT 13785..13939
FT /note="12"
FT /evidence="ECO:0000269|PubMed:11786729"
FT DOMAIN 13789..13909
FT /note="SEA 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT DOMAIN 13922..14043
FT /note="SEA 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT DOMAIN 14073..14193
FT /note="SEA 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT DOMAIN 14198..14309
FT /note="SEA 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT DOMAIN 14319..14438
FT /note="SEA 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT REGION 1..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1082..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1121..1149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1301..1378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1593..1641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1704..1757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1846..1930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2010..2033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2064..2140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2153..2177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2393..2455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2566..2591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2789..2822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2838..2885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2901..3006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3019..3052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3083..3148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3172..3235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3251..3276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3299..3392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3415..3436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3462..3491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3538..3588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3644..3672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3794..3829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3843..3879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3914..3982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4024..4056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4094..4121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4138..4166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4728..4748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4845..4961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5026..5066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5128..5149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5221..5249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5271..5303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5328..5365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5381..5400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5426..5507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5519..5538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5624..5654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5675..5696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5727..5747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5882..5931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6054..6078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6122..6149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6219..6251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6399..6425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6438..6459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6497..6545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6682..6714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6800..6822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6845..6865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6886..6939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6981..7004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7028..7107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7143..7208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7279..7302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7320..7345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7360..7427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7437..7456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7463..7503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7527..7553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7577..7597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7726..7782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7825..7849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7908..7927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7970..8000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8042..8078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8111..8134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8312..8331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8342..8389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8411..8472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8604..8624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8674..8741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8775..8880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8995..9018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9147..9168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9294..9460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9611..9635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9726..9753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9771..9791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9869..9890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10175..10218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10445..10469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10544..10590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10689..10719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10849..10872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10898..10926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11003..11036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11072..11092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11269..11301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11358..11400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11508..11537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11583..11724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11836..11861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11913..11937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 12067..13939
FT /note="12 X approximate tandem repeats"
FT /evidence="ECO:0000269|PubMed:11786729"
FT REGION 12196..12226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 12353..12376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 12819..12849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 12978..13003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 13291..13317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 13603..13625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2857..2885
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2901..2966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3299..3383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3846..3879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5221..5242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5519..5534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6497..6523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7143..7159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7168..7208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7387..7427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7726..7754
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7762..7782
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8313..8331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8775..8830
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8844..8880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9294..9413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9424..9460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9616..9635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10175..10217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10449..10469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13291..13315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 434
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 787
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 930
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 957
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1375
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1633
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1840
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1877
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1890
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2345
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2375
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2737
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3085
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3501
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4220
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4498
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4606
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4613
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4624
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4861
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5096
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5131
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5228
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5320
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5394
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5470
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5689
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5863
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 6088
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 6732
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 6859
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 6961
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 8029
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 8055
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 8324
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 8618
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 8684
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 8913
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 9202
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 9493
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 9785
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 10075
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 10173
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 10510
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 10700
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 10749
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 11053
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 11224
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 11263
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 11367
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 11594
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12079
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12116
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12235
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12272
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12393
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12414
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12430
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12549
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12570
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12586
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12704
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12725
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12741
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12824
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12860
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12881
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12897
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13016
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13037
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13053
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13193
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13328
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13349
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13365
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13484
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13505
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13521
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13640
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13661
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13733
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13744
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13796
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13816
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13832
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13929
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13950
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 14080
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 14100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 14195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 14212
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 14254
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 14287
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 14326
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 14363
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 14417
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 14423
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 12126..12146
FT /evidence="ECO:0000255"
FT DISULFID 12282..12302
FT /evidence="ECO:0000255"
FT DISULFID 12440..12460
FT /evidence="ECO:0000255"
FT DISULFID 12596..12616
FT /evidence="ECO:0000255"
FT DISULFID 12751..12771
FT /evidence="ECO:0000255"
FT DISULFID 12907..12927
FT /evidence="ECO:0000255"
FT DISULFID 13063..13083
FT /evidence="ECO:0000255"
FT DISULFID 13219..13239
FT /evidence="ECO:0000255"
FT DISULFID 13375..13395
FT /evidence="ECO:0000255"
FT DISULFID 13531..13551
FT /evidence="ECO:0000255"
FT DISULFID 13687..13707
FT /evidence="ECO:0000255"
FT DISULFID 13976..13996
FT /evidence="ECO:0000255"
FT DISULFID 14126..14146
FT /evidence="ECO:0000255"
FT DISULFID 14373..14393
FT /evidence="ECO:0000255"
FT VARIANT 545
FT /note="T -> A (in dbSNP:rs17000957)"
FT /id="VAR_056592"
FT VARIANT 1015
FT /note="R -> G (in dbSNP:rs17000950)"
FT /id="VAR_056593"
FT VARIANT 1032
FT /note="S -> T (in dbSNP:rs10411228)"
FT /id="VAR_056594"
FT VARIANT 1041
FT /note="P -> S (in dbSNP:rs10406202)"
FT /id="VAR_056595"
FT VARIANT 1162
FT /note="T -> I (in dbSNP:rs17000947)"
FT /id="VAR_056596"
FT VARIANT 1266
FT /note="K -> N (in dbSNP:rs1596797)"
FT /id="VAR_056597"
FT VARIANT 1353
FT /note="H -> Y (in dbSNP:rs12611293)"
FT /id="VAR_056598"
FT VARIANT 1400
FT /note="K -> N (in dbSNP:rs1596798)"
FT /id="VAR_056599"
FT VARIANT 1833
FT /note="L -> F (in dbSNP:rs4520945)"
FT /id="VAR_056600"
FT VARIANT 1953
FT /note="S -> P (in dbSNP:rs1108380)"
FT /id="VAR_056601"
FT VARIANT 2058
FT /note="S -> P (in dbSNP:rs1574479)"
FT /id="VAR_056602"
FT VARIANT 2150
FT /note="I -> V (in dbSNP:rs10407633)"
FT /id="VAR_056603"
FT VARIANT 2271
FT /note="T -> A (in dbSNP:rs11085805)"
FT /id="VAR_056604"
FT VARIANT 2288
FT /note="V -> L (in dbSNP:rs10410933)"
FT /id="VAR_056605"
FT VARIANT 2356
FT /note="D -> E (in dbSNP:rs10416013)"
FT /id="VAR_056606"
FT VARIANT 2747
FT /note="A -> T (in dbSNP:rs10402538)"
FT /id="VAR_056607"
FT VARIANT 2786
FT /note="M -> I (in dbSNP:rs17000886)"
FT /id="VAR_056608"
FT VARIANT 2834
FT /note="T -> M (in dbSNP:rs10407623)"
FT /id="VAR_056609"
FT VARIANT 3573
FT /note="R -> H (in dbSNP:rs2591594)"
FT /id="VAR_056610"
FT VARIANT 5741
FT /note="H -> D (in dbSNP:rs1559172)"
FT /id="VAR_056611"
FT VARIANT 5754
FT /note="A -> T (in dbSNP:rs1559171)"
FT /id="VAR_056612"
FT VARIANT 5852
FT /note="F -> V (in dbSNP:rs1862460)"
FT /id="VAR_056613"
FT VARIANT 7063
FT /note="T -> A (in dbSNP:rs17000770)"
FT /id="VAR_056614"
FT VARIANT 7272
FT /note="I -> V (in dbSNP:rs1867691)"
FT /id="VAR_056615"
FT VARIANT 10507
FT /note="T -> N (in dbSNP:rs11670461)"
FT /id="VAR_056616"
FT CONFLICT 1898
FT /note="Y -> D (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 2506
FT /note="T -> A (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 3190
FT /note="S -> T (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 3202
FT /note="M -> V (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 3932
FT /note="I -> V (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 4440
FT /note="S -> T (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 5682
FT /note="P -> T (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 6303
FT /note="V -> M (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 6655
FT /note="L -> V (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 6866
FT /note="E -> V (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 6895
FT /note="S -> C (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 6906
FT /note="A -> T (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 7191
FT /note="S -> F (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 7425
FT /note="L -> P (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 7475
FT /note="S -> P (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 7923
FT /note="D -> A (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 8301
FT /note="N -> T (in Ref. 2; AAL65133 and 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 8344
FT /note="D -> A (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 8578
FT /note="T -> A (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 9059
FT /note="T -> S (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 9072
FT /note="T -> A (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 9129
FT /note="D -> E (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 9213
FT /note="I -> T (in Ref. 2; AAL65133 and 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 9405
FT /note="Q -> R (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 9502
FT /note="A -> T (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 9608
FT /note="P -> S (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 9850
FT /note="D -> E (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 9899
FT /note="Y -> F (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 9920
FT /note="I -> T (in Ref. 2; AAL65133 and 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 10013
FT /note="L -> P (in Ref. 2; AAL65133 and 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 10169
FT /note="F -> L (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 10394
FT /note="S -> T (in Ref. 2; AAL65133)"
FT /evidence="ECO:0000305"
FT CONFLICT 10828
FT /note="P -> S (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 11154
FT /note="S -> F (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 11199
FT /note="A -> G (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 11455
FT /note="G -> D (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 12514
FT /note="S -> T (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 12580
FT /note="L -> V (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 12692
FT /note="T -> TSA (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 12832
FT /note="T -> A (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12834
FT /note="D -> H (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12836
FT /note="G -> E (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12842
FT /note="S -> A (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12846..12847
FT /note="SP -> GH (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12849..12850
FT /note="SA -> AP (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12873
FT /note="H -> R (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12892..12894
FT /note="GPM -> KPL (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12897
FT /note="N -> S (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12902
FT /note="L -> P (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12917
FT /note="N -> R (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12923..12925
FT /note="MDA -> VDT (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12928
FT /note="S -> T (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12934..12935
FT /note="KS -> LN (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12939
FT /note="N -> D (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12949
FT /note="Q -> K (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12952
FT /note="H -> R (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12955
FT /note="K -> I (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12961
FT /note="T -> L (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12965
FT /note="N -> G (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12976..12977
FT /note="SS -> NF (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12979..12980
FT /note="AP -> PI (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12990
FT /note="D -> H (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 12995
FT /note="G -> E (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 13002..13007
FT /note="SPTTAV -> RPIVPG (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 13025..13027
FT /note="GED -> EEA (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 13048
FT /note="G -> R (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 13054..13056
FT /note="SSV -> TSI (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 13062
FT /note="G -> S (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 13332
FT /note="T -> I (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 13341
FT /note="R -> H (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 13386
FT /note="G -> K (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 13394
FT /note="V -> I (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 13398
FT /note="R -> H (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 13402
FT /note="K -> Q (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 13407
FT /note="D -> N (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 13410
FT /note="R -> Q (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 13414
FT /note="K -> E (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 13472
FT /note="M -> T (in Ref. 6; BAC87568 and 4; AAK74120)"
FT /evidence="ECO:0000305"
FT CONFLICT 14041..14050
FT /note="YNEPGPDEPP -> HHTLQRQSTT (in Ref. 6; BAC87568)"
FT /evidence="ECO:0000305"
FT CONFLICT 14466
FT /note="V -> L (in Ref. 4; AAK74120)"
FT /evidence="ECO:0000305"
FT STRAND 12699..12707
FT /evidence="ECO:0007829|PDB:7SA9"
FT HELIX 12714..12717
FT /evidence="ECO:0007829|PDB:7SA9"
FT HELIX 12722..12740
FT /evidence="ECO:0007829|PDB:7SA9"
FT HELIX 12745..12747
FT /evidence="ECO:0007829|PDB:7SA9"
FT STRAND 12748..12759
FT /evidence="ECO:0007829|PDB:7SA9"
FT HELIX 12760..12762
FT /evidence="ECO:0007829|PDB:7SA9"
FT STRAND 12764..12773
FT /evidence="ECO:0007829|PDB:7SA9"
FT HELIX 12784..12794
FT /evidence="ECO:0007829|PDB:7SA9"
FT TURN 12795..12799
FT /evidence="ECO:0007829|PDB:7SA9"
FT STRAND 12804..12806
FT /evidence="ECO:0007829|PDB:7SA9"
SQ SEQUENCE 14507 AA; 1519175 MW; 7D5E9A14F70EB90A CRC64;
MLKPSGLPGS SSPTRSLMTG SRSTKATPEM DSGLTGATLS PKTSTGAIVV TEHTLPFTSP
DKTLASPTSS VVGRTTQSLG VMSSALPEST SRGMTHSEQR TSPSLSPQVN GTPSRNYPAT
SMVSGLSSPR TRTSSTEGNF TKEASTYTLT VETTSGPVTE KYTVPTETST TEGDSTETPW
DTRYIPVKIT SPMKTFADST ASKENAPVSM TPAETTVTDS HTPGRTNPSF GTLYSSFLDL
SPKGTPNSRG ETSLELILST TGYPFSSPEP GSAGHSRIST SAPLSSSASV LDNKISETSI
FSGQSLTSPL SPGVPEARAS TMPNSAIPFS MTLSNAETSA ERVRSTISSL GTPSISTKQT
AETILTFHAF AETMDIPSTH IAKTLASEWL GSPGTLGGTS TSALTTTSPS TTLVSEETNT
HHSTSGKETE GTLNTSMTPL ETSAPGEESE MTATLVPTLG FTTLDSKIRS PSQVSSSHPT
RELRTTGSTS GRQSSSTAAH GSSDILRATT SSTSKASSWT SESTAQQFSE PQHTQWVETS
PSMKTERPPA STSVAAPITT SVPSVVSGFT TLKTSSTKGI WLEETSADTL IGESTAGPTT
HQFAVPTGIS MTGGSSTRGS QGTTHLLTRA TASSETSADL TLATNGVPVS VSPAVSKTAA
GSSPPGGTKP SYTMVSSVIP ETSSLQSSAF REGTSLGLTP LNTRHPFSSP EPDSAGHTKI
STSIPLLSSA SVLEDKVSAT STFSHHKATS SITTGTPEIS TKTKPSSAVL SSMTLSNAAT
SPERVRNATS PLTHPSPSGE ETAGSVLTLS TSAETTDSPN IHPTGTLTSE SSESPSTLSL
PSVSGVKTTF SSSTPSTHLF TSGEETEETS NPSVSQPETS VSRVRTTLAS TSVPTPVFPT
MDTWPTRSAQ FSSSHLVSEL RATSSTSVTN STGSALPKIS HLTGTATMSQ TNRDTFNDSA
APQSTTWPET SPRFKTGLPS ATTTVSTSAT SLSATVMVSK FTSPATSSME ATSIREPSTT
ILTTETTNGP GSMAVASTNI PIGKGYITEG RLDTSHLPIG TTASSETSMD FTMAKESVSM
SVSPSQSMDA AGSSTPGRTS QFVDTFSDDV YHLTSREITI PRDGTSSALT PQMTATHPPS
PDPGSARSTW LGILSSSPSS PTPKVTMSST FSTQRVTTSM IMDTVETSRW NMPNLPSTTS
LTPSNIPTSG AIGKSTLVPL DTPSPATSLE ASEGGLPTLS TYPESTNTPS IHLGAHASSE
SPSTIKLTMA SVVKPGSYTP LTFPSIETHI HVSTARMAYS SGSSPEMTAP GETNTGSTWD
PTTYITTTDP KDTSSAQVST PHSVRTLRTT ENHPKTESAT PAAYSGSPKI SSSPNLTSPA
TKAWTITDTT EHSTQLHYTK LAEKSSGFET QSAPGPVSVV IPTSPTIGSS TLELTSDVPG
EPLVLAPSEQ TTITLPMATW LSTSLTEEMA STDLDISSPS SPMSTFAIFP PMSTPSHELS
KSEADTSAIR NTDSTTLDQH LGIRSLGRTG DLTTVPITPL TTTWTSVIEH STQAQDTLSA
TMSPTHVTQS LKDQTSIPAS ASPSHLTEVY PELGTQGRSS SEATTFWKPS TDTLSREIET
GPTNIQSTPP MDNTTTGSSS SGVTLGIAHL PIGTSSPAET STNMALERRS STATVSMAGT
MGLLVTSAPG RSISQSLGRV SSVLSESTTE GVTDSSKGSS PRLNTQGNTA LSSSLEPSYA
EGSQMSTSIP LTSSPTTPDV EFIGGSTFWT KEVTTVMTSD ISKSSARTES SSATLMSTAL
GSTENTGKEK LRTASMDLPS PTPSMEVTPW ISLTLSNAPN TTDSLDLSHG VHTSSAGTLA
TDRSLNTGVT RASRLENGSD TSSKSLSMGN STHTSMTYTE KSEVSSSIHP RPETSAPGAE
TTLTSTPGNR AISLTLPFSS IPVEEVISTG ITSGPDINSA PMTHSPITPP TIVWTSTGTI
EQSTQPLHAV SSEKVSVQTQ STPYVNSVAV SASPTHENSV SSGSSTSSPY SSASLESLDS
TISRRNAITS WLWDLTTSLP TTTWPSTSLS EALSSGHSGV SNPSSTTTEF PLFSAASTSA
AKQRNPETET HGPQNTAAST LNTDASSVTG LSETPVGASI SSEVPLPMAI TSRSDVSGLT
SESTANPSLG TASSAGTKLT RTISLPTSES LVSFRMNKDP WTVSIPLGSH PTTNTETSIP
VNSAGPPGLS TVASDVIDTP SDGAESIPTV SFSPSPDTEV TTISHFPEKT THSFRTISSL
THELTSRVTP IPGDWMSSAM STKPTGASPS ITLGERRTIT SAAPTTSPIV LTASFTETST
VSLDNETTVK TSDILDARKT NELPSDSSSS SDLINTSIAS STMDVTKTAS ISPTSISGMT
ASSSPSLFSS DRPQVPTSTT ETNTATSPSV SSNTYSLDGG SNVGGTPSTL PPFTITHPVE
TSSALLAWSR PVRTFSTMVS TDTASGENPT SSNSVVTSVP APGTWTSVGS TTDLPAMGFL
KTSPAGEAHS LLASTIEPAT AFTPHLSAAV VTGSSATSEA SLLTTSESKA IHSSPQTPTT
PTSGANWETS ATPESLLVVT ETSDTTLTSK ILVTDTILFS TVSTPPSKFP STGTLSGASF
PTLLPDTPAI PLTATEPTSS LATSFDSTPL VTIASDSLGT VPETTLTMSE TSNGDALVLK
TVSNPDRSIP GITIQGVTES PLHPSSTSPS KIVAPRNTTY EGSITVALST LPAGTTGSLV
FSQSSENSET TALVDSSAGL ERASVMPLTT GSQGMASSGG IRSGSTHSTG TKTFSSLPLT
MNPGEVTAMS EITTNRLTAT QSTAPKGIPV KPTSAESGLL TPVSASSSPS KAFASLTTAP
PTWGIPQSTL TFEFSEVPSL DTKSASLPTP GQSLNTIPDS DASTASSSLS KSPEKNPRAR
MMTSTKAISA SSFQSTGFTE TPEGSASPSM AGHEPRVPTS GTGDPRYASE SMSYPDPSKA
SSAMTSTSLA SKLTTLFSTG QAARSGSSSS PISLSTEKET SFLSPTASTS RKTSLFLGPS
MARQPNILVH LQTSALTLSP TSTLNMSQEE PPELTSSQTI AEEEGTTAET QTLTFTPSET
PTSLLPVSSP TEPTARRKSS PETWASSISV PAKTSLVETT DGTLVTTIKM SSQAAQGNST
WPAPAEETGS SPAGTSPGSP EMSTTLKIMS SKEPSISPEI RSTVRNSPWK TPETTVPMET
TVEPVTLQST ALGSGSTSIS HLPTGTTSPT KSPTENMLAT ERVSLSPSPP EAWTNLYSGT
PGGTRQSLAT MSSVSLESPT ARSITGTGQQ SSPELVSKTT GMEFSMWHGS TGGTTGDTHV
SLSTSSNILE DPVTSPNSVS SLTDKSKHKT ETWVSTTAIP STVLNNKIMA AEQQTSRSVD
EAYSSTSSWS DQTSGSDITL GASPDVTNTL YITSTAQTTS LVSLPSGDQG ITSLTNPSGG
KTSSASSVTS PSIGLETLRA NVSAVKSDIA PTAGHLSQTS SPAEVSILDV TTAPTPGIST
TITTMGTNSI STTTPNPEVG MSTMDSTPAT ERRTTSTEHP STWSSTAASD SWTVTDMTSN
LKVARSPGTI STMHTTSFLA SSTELDSMST PHGRITVIGT SLVTPSSDAS AVKTETSTSE
RTLSPSDTTA STPISTFSRV QRMSISVPDI LSTSWTPSST EAEDVPVSMV STDHASTKTD
PNTPLSTFLF DSLSTLDWDT GRSLSSATAT TSAPQGATTP QELTLETMIS PATSQLPFSI
GHITSAVTPA AMARSSGVTF SRPDPTSKKA EQTSTQLPTT TSAHPGQVPR SAATTLDVIP
HTAKTPDATF QRQGQTALTT EARATSDSWN EKEKSTPSAP WITEMMNSVS EDTIKEVTSS
SSVLRTLNTL DINLESGTTS SPSWKSSPYE RIAPSESTTD KEAIHPSTNT VETTGWVTSS
EHASHSTIPA HSASSKLTSP VVTTSTREQA IVSMSTTTWP ESTRARTEPN SFLTIELRDV
SPYMDTSSTT QTSIISSPGS TAITKGPRTE ITSSKRISSS FLAQSMRSSD SPSEAITRLS
NFPAMTESGG MILAMQTSPP GATSLSAPTL DTSATASWTG TPLATTQRFT YSEKTTLFSK
GPEDTSQPSP PSVEETSSSS SLVPIHATTS PSNILLTSQG HSPSSTPPVT SVFLSETSGL
GKTTDMSRIS LEPGTSLPPN LSSTAGEALS TYEASRDTKA IHHSADTAVT NMEATSSEYS
PIPGHTKPSK ATSPLVTSHI MGDITSSTSV FGSSETTEIE TVSSVNQGLQ ERSTSQVASS
ATETSTVITH VSSGDATTHV TKTQATFSSG TSISSPHQFI TSTNTFTDVS TNPSTSLIMT
ESSGVTITTQ TGPTGAATQG PYLLDTSTMP YLTETPLAVT PDFMQSEKTT LISKGPKDVS
WTSPPSVAET SYPSSLTPFL VTTIPPATST LQGQHTSSPV SATSVLTSGL VKTTDMLNTS
MEPVTNSPQN LNNPSNEILA TLAATTDIET IHPSINKAVT NMGTASSAHV LHSTLPVSSE
PSTATSPMVP ASSMGDALAS ISIPGSETTD IEGEPTSSLT AGRKENSTLQ EMNSTTESNI
ILSNVSVGAI TEATKMEVPS FDATFIPTPA QSTKFPDIFS VASSRLSNSP PMTISTHMTT
TQTGSSGATS KIPLALDTST LETSAGTPSV VTEGFAHSKI TTAMNNDVKD VSQTNPPFQD
EASSPSSQAP VLVTTLPSSV AFTPQWHSTS SPVSMSSVLT SSLVKTAGKV DTSLETVTSS
PQSMSNTLDD ISVTSAATTD IETTHPSINT VVTNVGTTGS AFESHSTVSA YPEPSKVTSP
NVTTSTMEDT TISRSIPKSS KTTRTETETT SSLTPKLRET SISQEITSST ETSTVPYKEL
TGATTEVSRT DVTSSSSTSF PGPDQSTVSL DISTETNTRL STSPIMTESA EITITTQTGP
HGATSQDTFT MDPSNTTPQA GIHSAMTHGF SQLDVTTLMS RIPQDVSWTS PPSVDKTSSP
SSFLSSPAMT TPSLISSTLP EDKLSSPMTS LLTSGLVKIT DILRTRLEPV TSSLPNFSST
SDKILATSKD SKDTKEIFPS INTEETNVKA NNSGHESHSP ALADSETPKA TTQMVITTTV
GDPAPSTSMP VHGSSETTNI KREPTYFLTP RLRETSTSQE SSFPTDTSFL LSKVPTGTIT
EVSSTGVNSS SKISTPDHDK STVPPDTFTG EIPRVFTSSI KTKSAEMTIT TQASPPESAS
HSTLPLDTST TLSQGGTHST VTQGFPYSEV TTLMGMGPGN VSWMTTPPVE ETSSVSSLMS
SPAMTSPSPV SSTSPQSIPS SPLPVTALPT SVLVTTTDVL GTTSPESVTS SPPNLSSITH
ERPATYKDTA HTEAAMHHST NTAVTNVGTS GSGHKSQSSV LADSETSKAT PLMSTTSTLG
DTSVSTSTPN ISQTNQIQTE PTASLSPRLR ESSTSEKTSS TTETNTAFSY VPTGAITQAS
RTEISSSRTS ISDLDRPTIA PDISTGMITR LFTSPIMTKS AEMTVTTQTT TPGATSQGIL
PWDTSTTLFQ GGTHSTVSQG FPHSEITTLR SRTPGDVSWM TTPPVEETSS GFSLMSPSMT
SPSPVSSTSP ESIPSSPLPV TALLTSVLVT TTNVLGTTSP EPVTSSPPNL SSPTQERLTT
YKDTAHTEAM HASMHTNTAV ANVGTSISGH ESQSSVPADS HTSKATSPMG ITFAMGDTSV
STSTPAFFET RIQTESTSSL IPGLRDTRTS EEINTVTETS TVLSEVPTTT TTEVSRTEVI
TSSRTTISGP DHSKMSPYIS TETITRLSTF PFVTGSTEMA ITNQTGPIGT ISQATLTLDT
SSTASWEGTH SPVTQRFPHS EETTTMSRST KGVSWQSPPS VEETSSPSSP VPLPAITSHS
SLYSAVSGSS PTSALPVTSL LTSGRRKTID MLDTHSELVT SSLPSASSFS GEILTSEAST
NTETIHFSEN TAETNMGTTN SMHKLHSSVS IHSQPSGHTP PKVTGSMMED AIVSTSTPGS
PETKNVDRDS TSPLTPELKE DSTALVMNST TESNTVFSSV SLDAATEVSR AEVTYYDPTF
MPASAQSTKS PDISPEASSS HSNSPPLTIS THKTIATQTG PSGVTSLGQL TLDTSTIATS
AGTPSARTQD FVDSETTSVM NNDLNDVLKT SPFSAEEANS LSSQAPLLVT TSPSPVTSTL
QEHSTSSLVS VTSVPTPTLA KITDMDTNLE PVTRSPQNLR NTLATSEATT DTHTMHPSIN
TAVANVGTTS SPNEFYFTVS PDSDPYKATS AVVITSTSGD SIVSTSMPRS SAMKKIESET
TFSLIFRLRE TSTSQKIGSS SDTSTVFDKA FTAATTEVSR TELTSSSRTS IQGTEKPTMS
PDTSTRSVTM LSTFAGLTKS EERTIATQTG PHRATSQGTL TWDTSITTSQ AGTHSAMTHG
FSQLDLSTLT SRVPEYISGT SPPSVEKTSS SSSLLSLPAI TSPSPVPTTL PESRPSSPVH
LTSLPTSGLV KTTDMLASVA SLPPNLGSTS HKIPTTSEDI KDTEKMYPST NIAVTNVGTT
TSEKESYSSV PAYSEPPKVT SPMVTSFNIR DTIVSTSMPG SSEITRIEME STFSLAHGLK
GTSTSQDPIV STEKSAVLHK LTTGATETSR TEVASSRRTS IPGPDHSTES PDISTEVIPS
LPISLGITES SNMTIITRTG PPLGSTSQGT FTLDTPTTSS RAGTHSMATQ EFPHSEMTTV
MNKDPEILSW TIPPSIEKTS FSSSLMPSPA MTSPPVSSTL PKTIHTTPSP MTSLLTPSLV
MTTDTLGTSP EPTTSSPPNL SSTSHEILTT DEDTTAIEAM HPSTSTAATN VETTSSGHGS
QSSVLADSEK TKATAPMDTT STMGHTTVST SMSVSSETTK IKRESTYSLT PGLRETSISQ
NASFSTDTSI VLSEVPTGTT AEVSRTEVTS SGRTSIPGPS QSTVLPEIST RTMTRLFASP
TMTESAEMTI PTQTGPSGST SQDTLTLDTS TTKSQAKTHS TLTQRFPHSE MTTLMSRGPG
DMSWQSSPSL ENPSSLPSLL SLPATTSPPP ISSTLPVTIS SSPLPVTSLL TSSPVTTTDM
LHTSPELVTS SPPKLSHTSD ERLTTGKDTT NTEAVHPSTN TAASNVEIPS SGHESPSSAL
ADSETSKATS PMFITSTQED TTVAISTPHF LETSRIQKES ISSLSPKLRE TGSSVETSSA
IETSAVLSEV SIGATTEISR TEVTSSSRTS ISGSAESTML PEISTTRKII KFPTSPILAE
SSEMTIKTQT SPPGSTSEST FTLDTSTTPS LVITHSTMTQ RLPHSEITTL VSRGAGDVPR
PSSLPVEETS PPSSQLSLSA MISPSPVSST LPASSHSSSA SVTSLLTPGQ VKTTEVLDAS
AEPETSSPPS LSSTSVEILA TSEVTTDTEK IHPFSNTAVT KVGTSSSGHE SPSSVLPDSE
TTKATSAMGT ISIMGDTSVS TLTPALSNTR KIQSEPASSL TTRLRETSTS EETSLATEAN
TVLSKVSTGA TTEVSRTEAI SFSRTSMSGP EQSTMSQDIS IGTIPRISAS SVLTESAKMT
ITTQTGPSES TLESTLNLNT ATTPSWVETH SIVIQGFPHP EMTTSMGRGP GGVSWPSPPF
VKETSPPSSP LSLPAVTSPH PVSTTFLAHI PPSPLPVTSL LTSGPATTTD ILGTSTEPGT
SSSSSLSTTS HERLTTYKDT AHTEAVHPST NTGGTNVATT SSGYKSQSSV LADSSPMCTT
STMGDTSVLT STPAFLETRR IQTELASSLT PGLRESSGSE GTSSGTKMST VLSKVPTGAT
TEISKEDVTS IPGPAQSTIS PDISTRTVSW FSTSPVMTES AEITMNTHTS PLGATTQGTS
TLDTSSTTSL TMTHSTISQG FSHSQMSTLM RRGPEDVSWM SPPLLEKTRP SFSLMSSPAT
TSPSPVSSTL PESISSSPLP VTSLLTSGLA KTTDMLHKSS EPVTNSPANL SSTSVEILAT
SEVTTDTEKT HPSSNRTVTD VGTSSSGHES TSFVLADSQT SKVTSPMVIT STMEDTSVST
STPGFFETSR IQTEPTSSLT LGLRKTSSSE GTSLATEMST VLSGVPTGAT AEVSRTEVTS
SSRTSISGFA QLTVSPETST ETITRLPTSS IMTESAEMMI KTQTDPPGST PESTHTVDIS
TTPNWVETHS TVTQRFSHSE MTTLVSRSPG DMLWPSQSSV EETSSASSLL SLPATTSPSP
VSSTLVEDFP SASLPVTSLL NPGLVITTDR MGISREPGTS STSNLSSTSH ERLTTLEDTV
DTEDMQPSTH TAVTNVRTSI SGHESQSSVL SDSETPKATS PMGTTYTMGE TSVSISTSDF
FETSRIQIEP TSSLTSGLRE TSSSERISSA TEGSTVLSEV PSGATTEVSR TEVISSRGTS
MSGPDQFTIS PDISTEAITR LSTSPIMTES AESAITIETG SPGATSEGTL TLDTSTTTFW
SGTHSTASPG FSHSEMTTLM SRTPGDVPWP SLPSVEEASS VSSSLSSPAM TSTSFFSTLP
ESISSSPHPV TALLTLGPVK TTDMLRTSSE PETSSPPNLS STSAEILATS EVTKDREKIH
PSSNTPVVNV GTVIYKHLSP SSVLADLVTT KPTSPMATTS TLGNTSVSTS TPAFPETMMT
QPTSSLTSGL REISTSQETS SATERSASLS GMPTGATTKV SRTEALSLGR TSTPGPAQST
ISPEISTETI TRISTPLTTT GSAEMTITPK TGHSGASSQG TFTLDTSSRA SWPGTHSAAT
HRSPHSGMTT PMSRGPEDVS WPSRPSVEKT SPPSSLVSLS AVTSPSPLYS TPSESSHSSP
LRVTSLFTPV MMKTTDMLDT SLEPVTTSPP SMNITSDESL ATSKATMETE AIQLSENTAV
TQMGTISARQ EFYSSYPGLP EPSKVTSPVV TSSTIKDIVS TTIPASSEIT RIEMESTSTL
TPTPRETSTS QEIHSATKPS TVPYKALTSA TIEDSMTQVM SSSRGPSPDQ STMSQDISTE
VITRLSTSPI KTESTEMTIT TQTGSPGATS RGTLTLDTST TFMSGTHSTA SQGFSHSQMT
ALMSRTPGDV PWLSHPSVEE ASSASFSLSS PVMTSSSPVS STLPDSIHSS SLPVTSLLTS
GLVKTTELLG TSSEPETSSP PNLSSTSAEI LAITEVTTDT EKLEMTNVVT SGYTHESPSS
VLADSVTTKA TSSMGITYPT GDTNVLTSTP AFSDTSRIQT KSKLSLTPGL METSISEETS
SATEKSTVLS SVPTGATTEV SRTEAISSSR TSIPGPAQST MSSDTSMETI TRISTPLTRK
ESTDMAITPK TGPSGATSQG TFTLDSSSTA SWPGTHSATT QRFPQSVVTT PMSRGPEDVS
WPSPLSVEKN SPPSSLVSSS SVTSPSPLYS TPSGSSHSSP VPVTSLFTSI MMKATDMLDA
SLEPETTSAP NMNITSDESL AASKATTETE AIHVFENTAA SHVETTSATE ELYSSSPGFS
EPTKVISPVV TSSSIRDNMV STTMPGSSGI TRIEIESMSS LTPGLRETRT SQDITSSTET
STVLYKMPSG ATPEVSRTEV MPSSRTSIPG PAQSTMSLDI SDEVVTRLST SPIMTESAEI
TITTQTGYSL ATSQVTLPLG TSMTFLSGTH STMSQGLSHS EMTNLMSRGP ESLSWTSPRF
VETTRSSSSL TSLPLTTSLS PVSSTLLDSS PSSPLPVTSL ILPGLVKTTE VLDTSSEPKT
SSSPNLSSTS VEIPATSEIM TDTEKIHPSS NTAVAKVRTS SSVHESHSSV LADSETTITI
PSMGITSAVD DTTVFTSNPA FSETRRIPTE PTFSLTPGFR ETSTSEETTS ITETSAVLYG
VPTSATTEVS MTEIMSSNRI HIPDSDQSTM SPDIITEVIT RLSSSSMMSE STQMTITTQK
SSPGATAQST LTLATTTAPL ARTHSTVPPR FLHSEMTTLM SRSPENPSWK SSLFVEKTSS
SSSLLSLPVT TSPSVSSTLP QSIPSSSFSV TSLLTPGMVK TTDTSTEPGT SLSPNLSGTS
VEILAASEVT TDTEKIHPSS SMAVTNVGTT SSGHELYSSV SIHSEPSKAT YPVGTPSSMA
ETSISTSMPA NFETTGFEAE PFSHLTSGFR KTNMSLDTSS VTPTNTPSSP GSTHLLQSSK
TDFTSSAKTS SPDWPPASQY TEIPVDIITP FNASPSITES TGITSFPESR FTMSVTESTH
HLSTDLLPSA ETISTGTVMP SLSEAMTSFA TTGVPRAISG SGSPFSRTES GPGDATLSTI
AESLPSSTPV PFSSSTFTTT DSSTIPALHE ITSSSATPYR VDTSLGTESS TTEGRLVMVS
TLDTSSQPGR TSSSPILDTR MTESVELGTV TSAYQVPSLS TRLTRTDGIM EHITKIPNEA
AHRGTIRPVK GPQTSTSPAS PKGLHTGGTK RMETTTTALK TTTTALKTTS RATLTTSVYT
PTLGTLTPLN ASMQMASTIP TEMMITTPYV FPDVPETTSS LATSLGAETS TALPRTTPSV
FNRESETTAS LVSRSGAERS PVIQTLDVSS SEPDTTASWV IHPAETIPTV SKTTPNFFHS
ELDTVSSTAT SHGADVSSAI PTNISPSELD ALTPLVTISG TDTSTTFPTL TKSPHETETR
TTWLTHPAET SSTIPRTIPN FSHHESDATP SIATSPGAET SSAIPIMTVS PGAEDLVTSQ
VTSSGTDRNM TIPTLTLSPG EPKTIASLVT HPEAQTSSAI PTSTISPAVS RLVTSMVTSL
AAKTSTTNRA LTNSPGEPAT TVSLVTHPAQ TSPTVPWTTS IFFHSKSDTT PSMTTSHGAE
SSSAVPTPTV STEVPGVVTP LVTSSRAVIS TTIPILTLSP GEPETTPSMA TSHGEEASSA
IPTPTVSPGV PGVVTSLVTS SRAVTSTTIP ILTFSLGEPE TTPSMATSHG TEAGSAVPTV
LPEVPGMVTS LVASSRAVTS TTLPTLTLSP GEPETTPSMA TSHGAEASST VPTVSPEVPG
VVTSLVTSSS GVNSTSIPTL ILSPGELETT PSMATSHGAE ASSAVPTPTV SPGVSGVVTP
LVTSSRAVTS TTIPILTLSS SEPETTPSMA TSHGVEASSA VLTVSPEVPG MVTSLVTSSR
AVTSTTIPTL TISSDEPETT TSLVTHSEAK MISAIPTLAV SPTVQGLVTS LVTSSGSETS
AFSNLTVASS QPETIDSWVA HPGTEASSVV PTLTVSTGEP FTNISLVTHP AESSSTLPRT
TSRFSHSELD TMPSTVTSPE AESSSAISTT ISPGIPGVLT SLVTSSGRDI SATFPTVPES
PHESEATASW VTHPAVTSTT VPRTTPNYSH SEPDTTPSIA TSPGAEATSD FPTITVSPDV
PDMVTSQVTS SGTDTSITIP TLTLSSGEPE TTTSFITYSE THTSSAIPTL PVSPGASKML
TSLVISSGTD STTTFPTLTE TPYEPETTAI QLIHPAETNT MVPRTTPKFS HSKSDTTLPV
AITSPGPEAS SAVSTTTISP DMSDLVTSLV PSSGTDTSTT FPTLSETPYE PETTATWLTH
PAETSTTVSG TIPNFSHRGS DTAPSMVTSP GVDTRSGVPT TTIPPSIPGV VTSQVTSSAT
DTSTAIPTLT PSPGEPETTA SSATHPGTQT GFTVPIRTVP SSEPDTMASW VTHPPQTSTP
VSRTTSSFSH SSPDATPVMA TSPRTEASSA VLTTISPGAP EMVTSQITSS GAATSTTVPT
LTHSPGMPET TALLSTHPRT ETSKTFPAST VFPQVSETTA SLTIRPGAET STALPTQTTS
SLFTLLVTGT SRVDLSPTAS PGVSAKTAPL STHPGTETST MIPTSTLSLG LLETTGLLAT
SSSAETSTST LTLTVSPAVS GLSSASITTD KPQTVTSWNT ETSPSVTSVG PPEFSRTVTG
TTMTLIPSEM PTPPKTSHGE GVSPTTILRT TMVEATNLAT TGSSPTVAKT TTTFNTLAGS
LFTPLTTPGM STLASESVTS RTSYNHRSWI STTSSYNRRY WTPATSTPVT STFSPGISTS
SIPSSTAATV PFMVPFTLNF TITNLQYEED MRHPGSRKFN ATERELQGLL KPLFRNSSLE
YLYSGCRLAS LRPEKDSSAT AVDAICTHRP DPEDLGLDRE RLYWELSNLT NGIQELGPYT
LDRNSLYVNG FTHRSSMPTT STPGTSTVDV GTSGTPSSSP SPTTAGPLLM PFTLNFTITN
LQYEEDMRRT GSRKFNTMES VLQGLLKPLF KNTSVGPLYS GCRLTLLRPE KDGAATGVDA
ICTHRLDPKS PGLNREQLYW ELSKLTNDIE ELGPYTLDRN SLYVNGFTHQ SSVSTTSTPG
TSTVDLRTSG TPSSLSSPTI MAAGPLLVPF TLNFTITNLQ YGEDMGHPGS RKFNTTERVL
QGLLGPIFKN TSVGPLYSGC RLTSLRSEKD GAATGVDAIC IHHLDPKSPG LNRERLYWEL
SQLTNGIKEL GPYTLDRNSL YVNGFTHRTS VPTSSTPGTS TVDLGTSGTP FSLPSPATAG
PLLVLFTLNF TITNLKYEED MHRPGSRKFN TTERVLQTLL GPMFKNTSVG LLYSGCRLTL
LRSEKDGAAT GVDAICTHRL DPKSPGVDRE QLYWELSQLT NGIKELGPYT LDRNSLYVNG
FTHWIPVPTS STPGTSTVDL GSGTPSSLPS PTTAGPLLVP FTLNFTITNL KYEEDMHCPG
SRKFNTTERV LQSLLGPMFK NTSVGPLYSG CRLTLLRSEK DGAATGVDAI CTHRLDPKSP
GVDREQLYWE LSQLTNGIKE LGPYTLDRNS LYVNGFTHQT SAPNTSTPGT STVDLGTSGT
PSSLPSPTSA GPLLVPFTLN FTITNLQYEE DMHHPGSRKF NTTERVLQGL LGPMFKNTSV
GLLYSGCRLT LLRPEKNGAA TGMDAICSHR LDPKSPGLNR EQLYWELSQL THGIKELGPY
TLDRNSLYVN GFTHRSSVAP TSTPGTSTVD LGTSGTPSSL PSPTTAVPLL VPFTLNFTIT
NLQYGEDMRH PGSRKFNTTE RVLQGLLGPL FKNSSVGPLY SGCRLISLRS EKDGAATGVD
AICTHHLNPQ SPGLDREQLY WQLSQMTNGI KELGPYTLDR NSLYVNGFTH RSSGLTTSTP
WTSTVDLGTS GTPSPVPSPT TTGPLLVPFT LNFTITNLQY EENMGHPGSR KFNITESVLQ
GLLKPLFKST SVGPLYSGCR LTLLRPEKDG VATRVDAICT HRPDPKIPGL DRQQLYWELS
QLTHSITELG PYTLDRDSLY VNGFTQRSSV PTTSTPGTFT VQPETSETPS SLPGPTATGP
VLLPFTLNFT ITNLQYEEDM RRPGSRKFNT TERVLQGLLM PLFKNTSVSS LYSGCRLTLL
RPEKDGAATR VDAVCTHRPD PKSPGLDRER LYWKLSQLTH GITELGPYTL DRHSLYVNGF
THQSSMTTTR TPDTSTMHLA TSRTPASLSG PMTASPLLVL FTINFTITNL RYEENMHHPG
SRKFNTTERV LQGLLRPVFK NTSVGPLYSG CRLTLLRPKK DGAATKVDAI CTYRPDPKSP
GLDREQLYWE LSQLTHSITE LGPYTLDRDS LYVNGFTQRS SVPTTSIPGT PTVDLGTSGT
PVSKPGPSAA SPLLVLFTLN FTITNLRYEE NMQHPGSRKF NTTERVLQGL LRSLFKSTSV
GPLYSGCRLT LLRPEKDGTA TGVDAICTHH PDPKSPRLDR EQLYWELSQL THNITELGPY
ALDNDSLFVN GFTHRSSVST TSTPGTPTVY LGASKTPASI FGPSAASHLL ILFTLNFTIT
NLRYEENMWP GSRKFNTTER VLQGLLRPLF KNTSVGPLYS GCRLTLLRPE KDGEATGVDA
ICTHRPDPTG PGLDREQLYL ELSQLTHSIT ELGPYTLDRD SLYVNGFTHR SSVPTTSTGV
VSEEPFTLNF TINNLRYMAD MGQPGSLKFN ITDNVMQHLL SPLFQRSSLG ARYTGCRVIA
LRSVKNGAET RVDLLCTYLQ PLSGPGLPIK QVFHELSQQT HGITRLGPYS LDKDSLYLNG
YNEPGPDEPP TTPKPATTFL PPLSEATTAM GYHLKTLTLN FTISNLQYSP DMGKGSATFN
STEGVLQHLL RPLFQKSSMG PFYLGCQLIS LRPEKDGAAT GVDTTCTYHP DPVGPGLDIQ
QLYWELSQLT HGVTQLGFYV LDRDSLFING YAPQNLSIRG EYQINFHIVN WNLSNPDPTS
SEYITLLRDI QDKVTTLYKG SQLHDTFRFC LVTNLTMDSV LVTVKALFSS NLDPSLVEQV
FLDKTLNASF HWLGSTYQLV DIHVTEMESS VYQPTSSSST QHFYLNFTIT NLPYSQDKAQ
PGTTNYQRNK RNIEDALNQL FRNSSIKSYF SDCQVSTFRS VPNRHHTGVD SLCNFSPLAR
RVDRVAIYEE FLRMTRNGTQ LQNFTLDRSS VLVDGYSPNR NEPLTGNSDL PFWAVILIGL
AGLLGVITCL ICGVLVTTRR RKKEGEYNVQ QQCPGYYQSH LDLEDLQ
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